Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P20366 (substance P)
 21,176 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The cellular localization of substance P immunoreactivity was demonstrated at light microscopy level in hamster gonads during foetal and postnatal development. Selective immunostaining was observed in both the foetal and the adult generation of Leydig cells, but only in the luteal and interstitial cells of the adult ovary. To date there have been few studies dealing with the potential role of substance P in the control of gonadal functions. To examine whether it exerts an effect on gonadal steroidogenesis, the gonads of newborn, prepuberal and adult hamsters were cultured in vitro in the presence of substance P (10(-7) M), HCG (5 IU/ml) or substance P + HCG. Production of the sex steroid hormones testosterone, oestradiol-17 beta and progesterone was measured by radioimmunoassay. Substance P was observed to have a modulatory effect on steroid production by foetal, immature and mature gonads of both sexes.
 ...
PMID:Substance P: immunocytochemical localization and biological role in hamster gonads during ontogenesis. 172 97

A 54 year old woman suffered from acromegaly due to a pancreatic islet cell tumour producing GHRH. The tumour was demonstrated on CT scan. The diagnosis was established from elevated plasma levels of GHRH, GH and prolactin, and by the lack of signs of a pituitary adenoma in trans-sphenoidal surgery. Acromegaly was cured by tumour removal. Light microscopically, the tumour showed a medullary and microlobular pattern. The cells were large and often cuspidal. Small granules were found in semi-thin sections. Small aggregations of amyloid fibres were seen, mostly around capillaries. Immunocytochemistry revealed GHRH, NSE, neurotensin, serotonin, VIP and PP. S 100 was positive only in nerve fibres. Staining for GH, ACTH, calcitonin, alpha-HCG, beta-HCG, insulin, glucagon, gastrin, substance P, bombesin and somatostatin was negative. Ultrastructure showed oval partly lobulated nuclei with small nucleoli, moderate amounts of rough endoplasmic reticulum, many free ribosomes, some large Golgi fields and small numbers of secretory granules measuring 150 nm or, in a few cells, 650 nm. Only 4 other cases of pancreatic endocrine tumours causing acromegaly by ectopic GHRH secretion are described in the literature and these were similar to our case in many respects.
 ...
PMID:Morphology of a GHRH producing pancreatic islet cell tumour causing acromegaly. 301 79