Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P20366 (substance P)
 21,176 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Experiments were performed on 48 urethane-chloralose anaesthetized, gallamine triethiodide immobilized and vagotomized rabbits under artificial ventilation. Radiolabeled microspheres were injected into the left atrium during stimulation of the left or right dorsomedial hypothalamic nucleus (LDMH or RDMH) to measure regional myocardial blood flow (RMBF). RDMH stimulation produced relatively little flow reduction of the left ventricle, whereas LDMH stimulation produced an obvious flow reduction. No significant change occurred in the right ventricle. Meanwhile, LDMH or RDMH stimulation caused increases of mean arterial blood pressure (MABP) and changes of epicardial electrogram (EECG) ST segment, but no significant changes in heart rate. EECG ST segment was elevated in relation to the reduction of RMBF in left ventricle (r = -0.825, P less than 0.001). Linear regression analysis of MABP change in relation to left ventricle RMBF showed no significant correlation. In intact rabbits, it was demonstrated that DMH stimulation caused an decrease of substance P (SP) immunoreactive material in bilateral intermediolateral cell columns (IML) of T2-5 spinal cord concomitantly with an elevation in MABP and EECG ST changes. The results suggest that electrical stimulation of DMH can elicit coronary constriction, decrease in RMBF, elevation of EECG ST segment and increase in MABP, which may be mediated by the release of SP immunoreactive material in the IML of the spinal cord.
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PMID:[Effect of hypothalamic stimulation on RMBF and SP content in IML of spinal cord in rabbits]. 171 70

In the early stages of brain development, exposure of excessive monosodium glutamate (MSG) to neurons causes animal functional and behavioral disorders in adulthood. To investigate the effects of excessive MSG during pregnancy on the neurons in the developing brain, in situ hybridization was used. In mice, the expression of preprotachykinin A mRNA (PPT A mRNA) was assessed in neurons of in the brain after MSG treatment. Brain tissue sections were hybridized with specific digoxigenin-labeled RNA probes. The number of cells that expressed PPT A mRNA gradually decreased from 10-day-old (10d) to 60-day-old (60d) MSG-treated and normal animals. In the MSG-treated and normal mice, the PPT A mRNA-positive neurons almost disappeared in 90-day-old (90d) mice. The expression of PPT A mRNA significantly decreased at 10d in most of the brain regions of MSG-treated mice including the cerebral cortex (CC), hippocampal subregions of CA1, CA2 (CA1, CA2), habenula nucleus (HAB), hypothalamic periventricular nucleus (PE), hypothalamic arcuate nucleus (AR), median eminence (ME), amygdala nucleus (AMY), endopiriform nucleus (EN), and hypothalamic ventromedial nucleus (VMH) and dorsomedial nucleus (DMH). In the hippocampal CA4 subregions (CA4), paraventricular nucleus (PV) and caudate putamen (CPU), however, they were not significantly altered. Furthermore, in CC, hippocampal CA3 subregion (CA3), PE and EN regions the number of PPT A mRNA-positive neurons decreased at 20 days old (20d), but increased significantly in CA2 and CPU. At 30 days old (30d), the positive neuron number decreased in AMY, and they did not change in other regions. At 60d, the number of positive neurons significantly decreased in PV and ME, but increased in AMY. In the other observed regions, no changes were found. These results show that maternal administration of excessive MSG at a late stage of pregnancy significantly decreases PPT A mRNA expression in most of the brain regions of filial mice. This suggests that glutamate-induced excitotoxicity may affect the metabolism of precursors of substance P in developing brain neurons. The present study provides insights into the plasticity and vulnerability of neuron in different brain regions to glutamate excitotoxicity.
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PMID:Temporal and spatial expression of preprotachykinin A mRNA in the developing filial mice brain after maternal administration of monosodium glutamate at a late stage of pregnancy. 1730 97