Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P20366 (substance P)
 21,176 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Rats were sensitized by intranasal application of toluene diisocyanate as a nasal allergy model. By means of the Using chamber technique, rat nasal epithelial short-circuit current (Isc) was measured. Enhanced Isc of the rat nasal mucosa resulted from stimulation of substance P (SP) in a dose-dependent manner that could be inhibited by pretreatment with NK1 receptor antagonist CP-96345, the H1 receptor antagonist pyrilamine, the H2 receptor antagonist ranitidine, and the neurotoxin tetrodotoxin, respectively, to different extents. The results indicate that SP is able to cause ion secretion of the nasal mucosal epithelium, perhaps by activating mast cells to release histamine. These data suggest that mast cells and sensory nerves participate in the regulation of SP-induced ion secretion during nasal allergy.
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PMID:Effect of substance P on the short-circuit current of rat nasal mucosal epithelium. 971 70


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