Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P20366 (substance P)
 21,176 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. The effects of repeated electroconvulsive stimuli (ECS) on neuropeptide Y (NPY)-, neurokinin A (NKA)-, substance P (SP)- and neurotensin (NT)- like immunoreactivity (-LI) levels in specific rat brain regions were studied in order to establish changes in peptide tissue concentrations in time after the last ECS. 2. The rats were sacrificed 15 minutes, 60 minutes, 1 day, 7 days or 15 days after the sixth sham ECS or ECS, using focused microwave irradiation. 3. Following dissection of the brains, peptides were extracted and measured in extract aliquots by radioimmunoassays. 4. ECS increased NPY-LI in both right and left hippocampus, frontal cortex and occipital cortex at 15 min, 60 min and 1 day after the treatments. Seven days following the last treatment, NPY-LI concentrations were elevated in the left hippocampus and occipital cortex but not in the corresponding right structures. Fifteen days following the last ECS treatment no changes in NPY concentrations were seen. 5. Also NKA-LI was increased in both the right and left hippocampus; the duration of changes was identical to those of NPY-LI. 6. No effects on SP- or NT-LI were found. 7. These results are in line with our hypothesis that one of the ECT's mechanisms of action might involve its effects on NPY and NKA.
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PMID:Repeated electroconvulsive stimuli: changes in neuropeptide Y, neurotensin and tachykinin concentrations in time. 750 97

1. Concentrations of neuropeptide Y (NPY)-, neurokinin A (NKA)- and neurotensin (NT)-like immunoreactivity (-LI) were measured in brain tissues of Fawn Hooded (FH) (a model of depression), Wistar (W) (control for depression) and Sprague Dawley (SD) rats (control for strain) with the aim to explore possible associations between neuropeptides and models of depression. 2. In addition, peptides were determined after six electroconvulsive stimuli (ECS) or six sham ECS ("baseline") in order to investigate ECS mechanisms of action. 3. Baseline NPY-LI concentrations were markedly lower in the hippocampus of the "depressed" FH compared to the W and SD animals. 4. Baseline NKA-LI concentrations were higher in the occipital cortex and NT-LI concentrations in the occipital cortex, frontal cortex, and hypothalamus of the FH and W compared to the SD rats. 5. ECS increased NPY-LI in the hippocampus, frontal cortex and occipital cortex of all three strains. In the hippocampus, the increase was significantly larger in the FH compared to the W and SD rats. ECS also increased NKA-LI in the hippocampus. 6. In contrast, ECS decreased NT-LI in the occipital cortex of the FH and W animals. 7. The results indicate that NPY may play a role in depression and that changes in NPY and NKA probably constitute one of the mechanisms of ECT action. More speculatively, NT may also be involved in depression.
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PMID:Neuropeptide Y, neurokinin A and neurotensin in brain regions of Fawn Hooded "depressed", Wistar, and Sprague Dawley rats. Effects of electroconvulsive stimuli. 961 49