Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P20366 (substance P)
 21,176 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In this article the effects of stress-induced release of opioid peptides are integrated into the local (LAS) and general adaptation (GAS) syndrome. Findings are explained which plead for a participation in the LAS and AAS in the sense of a reserve mechanism for the maintenance of the homoeostasis. Three areas in which these opioid peptides possibly interact are discussed, articularly the adrenal glands because of their possible importance in effectuation of stress processes. Interactions between opioid system and catecholamines as well as of opioid peptides with substance P entitle to classify the opioid system as an effective regulator of biochemical processes in stress.
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PMID:[Stress and the endogenous opioid system. III. Classification of the opioid system in the process of adaptation]. 258 77

The effect of the anabolic androgenic steroid, nandrolone decanoate, on substance P endopeptidase-like activity was examined in adult male Sprague-Dawley rats. Nandrolone decanoate (15 mg/kg day) or oil vehicle (sterile arachidis oleum) were administered by intramuscular injections during 14 days. Substance P endopeptidase, a predominantly cytosolic enzyme, generates the bioactive N-terminal fragment substance P(1-7) from the enzyme substrate substance P. Nandrolone decanoate significantly reduced the substance P endopeptidase-like activity compared to control animals in hypothalamus (43% reduction), caudate putamen (44%), substantia nigra (32%) and the ventral tegmental area (27%). It was previously reported that both hypothalamus and caudate putamen contained significantly higher levels of substance P after nandrolone administration. The higher concentration of substance P in these regions could to an extent be attributed to the reduction in substance P endopeptidase-like activity. This result elucidates the important role of peptidase activity in the regulation of the substance P transmitter system. The present study provides additional support for the hypothesis that alterations in the substance P system in certain brain areas may contribute to some of the personality changes reported in connection with AAS abuse.
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PMID:Administration of the anabolic androgenic steroid nandrolone decanoate affects substance P endopeptidase-like activity in the rat brain. 1609 48