Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P20366 (substance P)
 21,176 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Substance P, a naturally occuring polypeptide of mammalian origin, has been implicated both as a neurotransmitter and a neurohormone. However, little is known of the ionic mechanisms underlying the postsynaptic response to substance P. In myenteric neurones Katayama and North reported substance P-evoked depolarisations (of varying latency) associated, surprisingly, with a decrease in membrane conductance. A direct measurement of reversal potential in normal ionic conditions was not achieved but it was suggested that substance P acts by reducing membrane potassium conductance. In contrast, work on salivary glands suggests that substance P evokes an increase in potassium conductance; however,electrophysiological work has not been carried out to verify this. We report here that substance P evokes a marked increase in rat parotid acinar cell membrane conductance associated with a potential change (latency 1.7 s) that reverses at about --65 mV. The reversal potential for substance P is shown to be identical to that obtained in the same cells for acetylcholine (ACh) and adrenaline. The identical membrane action of ACh, adrenaline and substance P, mediated by three separate receptor sites, suggests activation of a common effector mechanism.
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PMID:Substance P increases membrane conductance in parotid acinar cells. 735 16

Limited studies have shown that in intestinal schistosomosis, the enteric nervous tissue becomes inflamed, disrupted and destroyed by granulomas and peptides, amines and neurofilaments contents are altered. Therefore, immunoreactivities of vasoactive intestinal peptide and substance P were correlated to pathological lesions in the large intestine from pigs infected with Schistosoma japonicum. Ganglia situated within or near granulomas showed ganglionitis, and necrosis of neurons as well as infiltration by eosinophils, mast cells, lymphocytes, plasma cells, neutrophils and macrophages. The inner submucous and mucous plexuses were the most damaged. In all categories of inflamed areas, the vasoactive intestinal peptide-like immunoreactive was reduced in all plexuses whereas, that of substance P was increased both in the enteric nerve plexuses and enterochromaffin cells in lightly, moderately and severely inflamed tissues. However, both peptides were highly diminished or absent in very severe lesions and areas surrounding schistosome eggs and mature worms laying eggs in the submucosal veins. The alterations of the levels of vasoactive intestinal peptide and substance P were correlated with severity of inflammation. Our observations show alterations of vasoactive intestinal peptide and substance P contents in the local microenvironment in the vasoactive intestinal peptide- and substance P-mediated reflex pathways which regulate intestinal motility, epithelial transport and modulate immunity. These changes could cause alterations in bowel motility, electrolyte and fluid secretion, vascular and immune functions during S. japonicum infections in the pig. This may, therefore, partly play a role in the pathobiology of migration and egress of schistosome eggs as well as influence trapping of eggs in granulomas, and account for diarrhoea, loss of body weight and failure to thrive, which are recorded in schistosomosis.
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PMID:Vasoactive intestinal peptide and substance P-like immunoreactivities in the enteric nervous system of the pig correlate with the severity of pathological changes induced by Schistosoma japonicum. 1159 38