Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P20366 (substance P)
 21,176 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This preliminary study was designed to determine whether the neurotransmitter substance P was present in the middle carpal synovial membrane of the normal horse and whether the neuropeptide could be identified in the synovial fluid of normal horses and those with joint diseases. Immunocytochemistry on middle carpal synovial membrane biopsies from fresh cadavers was used to demonstrate substance P-containing neural elements. Substance P was most abundant in the subintimal portion of the membrane, with occasional filaments coursing via synovial fronds to the intimal portion. Radioimmunoassay techniques were used on acidified acetonitrile-preserved synovial fluid samples to measure substance P concentrations. Fluid from 9 joints of 5 normal horses and 6 joints of 4 horses with joint diseases were analysed. Disease conditions included acute and chronic osteoarthritis and osteochondrosis. Synovia from normal horses contained a mean concentration of substance P significantly less than that of horses with joint diseases (P less than 0.05). Elevated concentrations of neurotransmitters in diseased joints suggests a potential contribution to the pathophysiology of joint disorders in horses.
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PMID:Substance P in the synovial membrane and fluid of the equine middle carpal joint. 138 68

Osteochondral fragments from the axial proximoplantar/proximopalmar region of the proximal phalanx were removed from 38 joints in 30 horses. Ninety-three percent of the horses were Standardbreds, and 28 of the 30 had a low-grade lameness. All but 1 of the horses had hind limb involvement. A total of 43 fragments were removed. Most (71%) of the fragments involved the medial aspect of the joint and had to be dissected from a covering of synovial tissue. Histologically, the circumference of most fragments consisted of a transition zone at the attachment of the joint capsule, a region of nonarticular, non-weight-bearing cartilage, a region where organized, dense connective tissue, presumably remnants of the short sesamoidean ligament were attached, and a region consisting of irregular truncated bony surfaces covered by healing of chronic fracture. There were several areas of degenerate hyaline cartilage, but no areas of normal hyaline cartilage or areas containing related cartilage cores or other evidence of delayed endochondral ossification. Immunohistochemical staining of 4 segments from 1 horse revealed sensory substance P immunoreactive nerves in the fibrous tissue surrounding the bony fragments and within the central cancellous spaces. The histologic appearance suggests that these osteochondral fragments may be a result of fracture, rather than a manifestation of osteochondrosis.
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PMID:Histologic appearance of axial osteochondral fragments from the proximoplantar/proximopalmar aspect of the proximal phalanx in horses. 755 50