Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P20366 (substance P)
 21,176 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Dipeptidyl peptidase IV was enriched about 2000-fold from lymphocytes of chronic lymphocytic leukemia of T-type. The purification procedure involved immunoaffinity chromatography using antibodies raised with highly purified dipeptidyl peptidase IV from human placenta. The lymphocytic peptidase had a subunit Mr of 110,000. Its kinetic properties were similar to those of the placenta enzyme: Two N-terminal dipeptides were cleaved from substance P and from casomorphin, and naphthylamine was released from X-prolynaphthylamides with Km-values of about 0.02 mM. The lymphocytic peptidase was 10-fold less sensitive to zinc inhibition as compared to the placenta enzyme. Isoelectric focussing patterns of dipeptidyl peptidase IV in leukemic lymphocytes and in normal T-lymphocytes were very similar.
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PMID:Characterization of dipeptidyl peptidase IV from lymphocytes of chronic lymphocytic leukemia of T-type. 287 12

Tachykinins are a family of structurally related peptides, including substance P (SP), hemokinin-1 (HK-1), neurokinin A (NKA), and neurokinin B. SP and NKA have been shown to modulate hematopoiesis and rat/mouse HK-1 has been found to be involved in the survival and differentiation of mouse B-cells. This study was designed to assess the expression of tachykinins with a focus on human HK-1 (hHK-1) in human B lymphocytes and the role of these peptides in cell differentiation, apoptosis and proliferation. Expression of tachykinin and tachykinin receptor mRNA was determined quantitatively in human B lymphoproliferative malignancies and compared to normal B-cells. Expression of hHK-1 and NK(1) receptor, but not SP, was detected in human B-lymphocytes, and was up-regulated in B-lymphocytes from chronic lymphocytic leukemia and non-Hodgkin's lymphoma, while it was down-regulated in acute lymphoblastic leukemia. Moreover, hHK-1, in contrast to SP, was able to induce proliferation of human pre-B lymphocytes through a NK(1) receptor-independent mechanism. These data suggest a role for hHK-1 in normal and pathological B lymphopoiesis, and open the door to a better understanding of the physiopathological mechanisms leading to lymphoproliferative malignancies.
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PMID:Expression and proliferative effect of hemokinin-1 in human B-cells. 2133 11