Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P20366 (substance P)
 21,176 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Using voltage-time-dependent negative resistance characteristics of Voltage-Current curves of excitable cell membranes estimated without using artificial voltage clamp method, the author made a quantitative analysis of excitability of cell membranes and different conditions of transmembrane action potentials as a bias voltage to the negative resistance of the excitable cell membrane. The pacemaker cells were classified as "Astable Oscillators" and nonpacemaker excitable cells as "Monostable Oscillators," and application of a rapidly changing electromagnetic field to the cells was analyzed as a means of stimulating the cells. The understanding of the 10 essential electrical parameters is highly desirable for safe and effective electrical stimulation. Among these, emphasis was placed on the often neglected, important electrical parameters of "output impedance" of stimulation pulse wave complexes for + and - polarity components, as well as the importance of capacitive current (Ic = C.dV/dt) which depends on rise time as well as fall time of the stimulation pulse wave, and undesirable side effects of electrolysis phenomena due to excessive D.C. current. The difference and similarity between TENS (Transcutaneous Nerve Stimulation) and TES (Transcutaneous Electrical Stimulation), TENMS (Transcutaneous Electrical Nerve and Muscle Stimulation) or TMS (Transcutaneous Muscle Stimulation) was discussed. The author's clinical study indicated that effective TES (TENMS)--characterized by effective muscle contraction without creating pain with a pulse repetition rate approximately the same as the heart rate of the individual--can often give superior beneficial effects in improvement of micro-circulation and subsequent relief of pain and other symptoms compared with TENS that creates stimulation of large diameter sensory nerve fibers without creating significant muscle contraction. Such improvement is often accompanied by the abolishment of the pain with disappearance of local substance P and increase in local serotonin with disappearance of local L-tryptophan.
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PMID:Basic electrical parameters for safe and effective electro-therapeutics [electro-acupuncture, TES, TENMS (or TEMS), TENS and electro-magnetic field stimulation with or without drug field] for pain, neuromuscular skeletal problems, and circulatory disturbances. 289 68

Retrograde or antidromic stimulation of the nociceptive C fibres is known to lead to the release of sensory neuropeptides Substance P (SP) and Calcitonin Gene-Related Peptide (CGRP) by the peripheral endings of these ultra-thin nerve fibres. These neuropeptides have, among others, a vasodilatory effect, which explains why they play a role in the healing of soft tissues. Burst TENS (Transcutaneous Electric Nerve Stimulation) is known to be most effective in influencing C fibre-evoked activity. This is why burst TENS was used in a randomised study as a stimulus for the healing of the sutured Achilles tendon in 10 patients, versus 10 others who received no stimulus. There was one drop-out in each group, so that 2 x 9 patients remained available for the study. A needle biopsy, performed after six weeks, showed no significant influence of burst TENS on the histological healing stage, as compared with a rat study. However, a semi-quantitative evaluation of the number of fibroblasts showed a significant advantage for the stimulated group: p = 0.007. This means that burst TENS might influence healing of Achilles tendon sutures in man. But above all, it means that a histochemical study of the influence of burst TENS on the release of substance P and CGRP, after suture of the Achilles tendon in man, would be worthwhile.
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PMID:Influence of burst TENS stimulation on the healing of Achilles tendon suture in man. 1474 10

Retrograde or antidromic stimulation of the nociceptive C fibres is known to lead to the release of sensory neuropeptides, such as substance P (SP), by the peripheral endings of sensory unmyelinated C nerve fibres. These neuropeptides play a role in the healing of soft tissues. Burst TENS (Transcutaneous Electric Nerve Stimulation) is known to be most effective in influencing retrograde C fibre-evoked activity. This is why burst TENS was used in a randomised study as a stimulus for the healing of the sutured Achilles tendon in 9 patients, versus 9 others who received no stimulus. Originally, each group consisted of 10 patients, but there was a single drop-out in each group. Six weeks after surgery a needle biopsy sample was obtained, and stained with Movat's pentachrome stain. It showed a statistically significant influence of burst TENS on new collagen production, maturation of newly formed collagen and organisation of collagen. This suggests that burst TENS might positively influence healing of Achilles tendon suture in man.
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PMID:Influence of burst TENS stimulation on collagen formation after Achilles tendon suture in man. A histological evaluation with Movat's pentachrome stain. 1603 9