Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P20226 (TATA-binding protein)
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Human Gene/Protein
TBP-associated factor 172 14.6
BTAF1 protein 14.6
TATA-binding protein 14.6
BRFU 14.2
TFIIIB90 13.9
hTAFII55 13.9
TAFI48 13.8
TFIIA-gamma 13.6
TAFI110 13.6
Suppressor of cytokine signaling 6 13.6
HTEX4 13.6
transmembrane protein 79 13.6
transcription factor-like nuclear regulator 13.6
60S ribosomal protein L23 13.6
TAFI63 13.6
hTAFII100 13.6
TBP protein 13.6
TAF9L 13.6
H3 histone, family 3A 13.6
BTAF1 13.5
Transcription factor IIB 13.4
activator of basal transcription 1 13.3
TBP-associated factor 13.2
TAF13 13.2
TAF8 13.2
Heterogeneous nuclear ribonucleoprotein F 13.0
TBP-associated factor 11 13.0
TAF(II)135 13.0
TAF(II)30 12.8
TAF9 12.8
TAFII55 12.8
transcription factor IID 12.7
ZNF76 12.7
TBP-interacting protein 12.7
TAF2 12.7
TFIIA 12.7
MOT1 12.6
SNAP19 12.6
BRP44L 12.6
FAM48A 12.6
TAFII80 12.6
TAF11 12.6
transcription factor IIB 12.6
TFIID 12.4
TFIIB 12.3
TAF4 12.3
TIP120 12.3
TAF1C 12.3
TBP-related factor 2 12.3
neugrin 12.3
proteasome subunit C3 12.3
cytochrome c-1 12.3
TAF(I)63 12.3
TFIIIB 12.3
SPT3 12.2
SCA17 12.2
SGF29 12.1
ABT1-associated protein 12.0
PC4 protein 12.0
TAF6 11.9
TIP120B 11.9
TLF 11.9
TAF7 11.8
XDP 11.8
KLK13 mRNA 11.8
SPN1 11.8
SNAP50 11.8
SNAP43 11.8
TAF 11.8
TBP2 11.7
TIP120A 11.7
TAF7L 11.7
general transcription factor 11.6
RBP56 11.6
TFIIIC 11.6
CIF150 11.6
CIS4 11.6
CCAAT-box-binding transcription factor 11.6
TAF10 11.6
YEATS2 11.6
hypoxanthine phosphoribosyltransferase 1 11.5
NC2 11.5
RNA polymerase II CTD phosphatase 11.4
SNAP45 11.4
POLE4 11.4
TAF1A 11.4
BRF1 11.4
TAF5 11.4
YCL1 11.4
RESP18 11.4
atrophin 1 11.4
speriolin 11.4
TFIIF 11.4
SNAP190 11.3
TAF1 11.3
TAF1L 11.3
Selectivity Factor 1 11.3
P250 11.2
TFIIE-beta 11.2
RAP74 11.2
TRF4 11.1
ubiquitin-specific protease 3 11.1
TAF4B 11.1
MBF1 11.1
TAF3 11.1
JPH3 11.1
msg1 11.0
DYT3 11.0
SRPR 11.0
ribosomal protein L28 11.0
GPBP 11.0
RNA polymerase I subunit 10.9
PSMB1 10.9
amino-terminal enhancer of split 10.9
p38IP 10.9
NF-E4 10.9
TBP 10.9
TAF12 10.8
BRF 10.8
RTF1 10.8
TFIIE-alpha 10.8
MBIP 10.8
tom1 10.8
succinate dehydrogenase flavoprotein subunit 10.8
PDE10A2 10.8
RAP30 10.7
MED26 10.7
ASF1B 10.7
TAF1B 10.7
RPB9 10.6
MRG1 10.6
RecA-like protein 10.6
Transcription initiation factor IIB 10.6
ADA3 10.6
SNURF 10.5
ribosomal protein L23 10.5
UBTF 10.5
TRAP240 10.5
cell death activator 10.4
BDP1 10.4
peptidylprolyl isomerase A 10.4
tubulin beta chain 10.4
TIP49 10.4
TFB1 10.3
H2A.F/Z 10.3
WD-40 repeat protein 10.3
TBP1 10.3
RPB6 10.3
high mobility group 1 protein 10.3
SL1 10.2
Rvb2 10.2
YY2 10.2
rhombotin 10.2
B1 bradykinin receptor 10.2
Tho1 10.2
CTF1 10.2
positive cofactor 4 10.1
spinocerebellar ataxia 7 10.1
Hpa2 10.1
Rvb1 10.0
prostein 10.0
W80 10.0
DRAP1 10.0
STAU1 10.0
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein 10.0
TBN 10.0
TEX14 9.9
PAF49 9.9
HYOU1 9.9
CBF-B 9.9
brother of the regulator of imprinted sites 9.9
TFIIH 9.9
atrophin-1 9.9
succinate-semialdehyde dehydrogenase 9.8
OSF2 9.8
BTF1 9.8
GCN5 9.8
MTBP 9.8
B-cell-specific transcription factor 9.8
HOXB5 9.8
CADPS2 9.8
Npl3 9.8
ATF7 9.7
DSC3 9.7
Ral guanine nucleotide dissociation stimulator 9.7
ribosomal protein L34 9.7
polyadenylation specificity factor 9.7
NPM2 9.5
RPS5 9.5
UCE 9.5
TRF2 9.5
ataxin-7 9.5
RNA polymerase II 9.5
bystin 9.5
repressor activator protein 1 9.5
PETA-3 9.5
CBF-A 9.5
SCA8 9.5
heterogeneous nuclear ribonucleoprotein F 9.5
putative ATPases 9.5
Tal2 9.5
ribosomal protein L13a 9.5
SLC45A3 9.5
EF1a 9.4
PDCD2 9.4
Zn-finger protein 9.4
ADA2 9.4
NIM1 9.4
TIF 9.4
MINOR 9.3
hBRM 9.3
ACH2 9.3
RPB7 9.3
ataxin 2 9.3
TMP1 9.3
GTSE1 9.3
KLK13 9.3
7B2 protein 9.3
GAPDS 9.3
dentatorubral-pallidoluysian atrophy 9.3
heterochromatin protein-1 9.3
RNA polymerase I 9.3
PUT1 9.3
transcription factor TFIIH 9.3
cdc25B 9.2
TLP 9.2
SCA12 9.2
Spinocerebellar ataxia type 7 9.2
aaa 9.2
YBX2 9.2
REG1 9.1
ribosomal protein L29 9.1
MAF1 9.1
KAT2A 9.1
IMP-2 9.1
Ewing sarcoma breakpoint region 1 9.1
BNC1 9.0
PC4 9.0
ATX1 9.0
CDX1 9.0
SPT5 8.9
nuclear autoantigen 8.9
RPB4 8.9
RPB5 8.9
protein inhibitor of activated STAT1 8.9
UEV1A 8.9
Fox-2 8.9
UBF 8.8
testis determining factor 8.8
signal recognition particle receptor 8.8
RNA polymerase II subunit 8.8
E2F-5 8.8
G9A 8.8
Tumor suppressor protein 8.8
PLC1 8.8
TIP41 8.7
Ctr9 8.7
CAND1 8.7
potassium channel protein 8.7
TSA-1 8.7
POU domain protein 8.7
SUG1 8.6
SCA7 8.6
CstF-64 8.6
SEC63 8.6
hnRNP F 8.6
NPAT 8.6
TRRAP 8.5
GAL4 8.5
ADH5 8.5
ribosomal protein S15 8.5
DCoH 8.5
Transcription factor 8.5
ING2 8.5
cleavage stimulation factor 8.4
Rpn1 8.4
ribosomal protein P0 8.4
p19 protein 8.4
TFII-I 8.4
GAL1 8.4
RPS9 8.4
RREB1 8.4
TFIIS 8.3
runt-related transcription factor 1 8.3
SSD1 8.3
HERC1 8.3
USP10 8.3
hnRNPA1 8.3
kelch-like 8.3
TFDP3 8.3
NELF 8.3
BRE 8.2
ubiquitin-protein isopeptide ligase 8.2
NF-YC 8.2
HBO1 8.2
RIP140 8.2
ribosomal protein L4 8.2
HIS3 8.2
telomeric repeat binding factor 2 8.2
P4HB 8.2
PAF1 8.2
ITPR1 8.2
ALF 8.2
cell cycle regulatory protein 8.2
SPT 8.1
YTHDF1 8.1
IkappaB-zeta 8.1
HMGCS2 8.1
A49 8.1
coilin 8.1
factor 9 8.1
HSPA8 8.1
hydroxymethylglutaryl-CoA synthase 8.1
MAP3 8.1
LBP-1 8.1
CYC1 8.1
SCA1 8.1
SCA2 8.0
ADPRT 8.0
UTF1 8.0
more...
Disease
SCA17 12.5
Gopalan 10.9
HPC4 10.7
IDDM8 10.5
Vaccinia virus infection 10.5
HDL1 9.7
TALS 9.7
SCA8 9.7
Hughes syndrome 9.3
SCA12 9.2
XDP 9.2
Spinocerebellar ataxia 8.8
SCA7 8.6
CAA 8.4
FRDA 8.2
SCA1 8.0
SCA2 8.0
CAA 7.9
XPB 7.2
AD2 7.1
Machado-Joseph disease 7.1
CLN2 7.0
FTLD 7.0
SCA6 6.9
primary lateral sclerosis 6.9
FUS 6.7
AD1 6.7
TEC 6.5
HDL2 6.5
Bateman 6.3
CLN1 6.3
Recruitment 6.1
Forbes 6.1
MSS 6.0
HDL3 5.9
XPD 5.8
hemophilia B 5.8
bends 5.8
Frontotemporal dementia 5.7
torsion dystonia 5.7
CUP 5.7
epidermodysplasia verruciformis 5.7
PTP 5.6
LIP 5.6
Ewing's sarcoma 5.5
CJD 5.5
embryonal carcinoma 5.4
ISH 5.4
hyperphenylalaninemia 5.3
high-grade squamous intraepithelial lesion 5.1
Huntington's disease 5.1
Human immunodeficiency virus type 5.1
CAN 5.0
retinoblastoma 4.9
Pick's disease 4.9
NLS 4.9
PSP 4.8
African swine fever 4.8
HP1 4.7
Testis 4.6
Testis 4.6
progeria 4.5
cervical squamous cell carcinoma 4.5
hereditary spherocytosis 4.4
EL4 4.4
LAP 4.4
thrombophlebitis 4.3
anaplastic astrocytoma 4.3
brain atrophy 4.3
primitive neuroectodermal tumor 4.3
Schmidt 4.2
hypergammaglobulinemia 4.2
apraxia 4.1
movement disorder 4.0
Adenovirus 4.0
stuttering 4.0
primitive neuroectodermal tumor 4.0
parkinsonism 3.9
Dementia with Lewy bodies 3.9
herpes simplex 3.9
Cerebellum 3.8
Nasopharyngeal carcinoma 3.8
azoospermia 3.8
Dissociation 3.7
amyotrophic lateral sclerosis 3.7
cytomegalovirus 3.7
Nelson 3.6
Friedreich's ataxia 3.5
dysphonia 3.5
PML 3.5
amebiasis 3.5
brain cancer 3.5
WRN 3.5
premature aging 3.5
Q fever 3.5
Hashimoto's thyroiditis 3.5
paracoccidioidomycosis 3.4
ARC 3.3
spongiform encephalopathy 3.2
hairy cell leukemia 3.2
HAM 3.2
hepatoblastoma 3.2
degenerative disease 3.1
sarcoma 3.1
mimicry 3.1
African trypanosomiasis 3.1
Rous sarcoma 3.0
AAA 3.0
neurological disease 3.0
hepatitis B 2.9
polymyositis 2.9
mammary tumor 2.9
latent infection 2.9
progressive supranuclear palsy 2.9
thalassemia 2.8
Epstein 2.8
liposarcoma 2.8
vitiligo 2.8
dementia 2.8
hemorrhagic fever 2.8
vaccinia 2.8
fragile X syndrome 2.8
neurofibromatosis type 1 2.6
leukemogenesis 2.6
choriocarcinoma 2.6
dermatomyositis 2.6
toxic shock syndrome 2.6
DM1 2.5
Creutzfeldt-Jakob disease 2.5
chondrosarcoma 2.5
varicella 2.5
stomatitis 2.5
cervical intraepithelial neoplasia 2.4
ABL 2.4
bipolar disorder 2.4
tumorigenesis 2.4
neoplastic transformation 2.3
MIP 2.3
SLE 2.3
mole 2.2
male infertility 2.2
liver cancer 2.1
mole 2.0
aggressiveness 2.0
temporal lobe epilepsy 2.0
bronchitis 2.0
immunodeficiency 1.9
NOD 1.9
aphasia 1.8
bronchitis 1.8
leukopenia 1.7
nystagmus 1.7
liver cancer 1.7
developmental delay 1.6
Cryptococcus neoformans 1.6
epididymis 1.6
SDS 1.5
abdominal aortic aneurysm 1.5
Kaposi's sarcoma 1.5
hepatocellular carcinoma 1.5
Blocking 1.4
MCF 1.4
virus infection 1.3
ICP 1.3
hepatitis 1.3
glioma 1.3
leukemia 1.2
PSS 1.2
cervical cancer 1.1
non-small cell lung cancer 1.1
emphysema 1.1
prostate cancer 1.0
Brown 1.0
carcinogenesis 0.9
neuroblastoma 0.8
myelopathy 0.8
ovarian cancer 0.8
glomerulonephritis 0.8
malnutrition 0.8
systemic lupus erythematosus 0.7
Colon 0.7
Colon 0.7
Colon 0.7
Haemophilus 0.7
lupus 0.7
Parkinson's disease 0.6
epilepsy 0.6
myocardial infarction 0.6
hepatitis C 0.5
Best 0.5
encephalopathy 0.4
cognitive impairment 0.4
glioblastoma 0.4
HIV 0.4
Infection 0.4
schizophrenia 0.3
psoriasis 0.2
cardiomyopathy 0.2
major depressive disorder 0.2
cardiovascular disease 0.2
Alzheimer's disease 0.2
lupus 0.1
malaria 0.1
tumor 0.1
dehydration 0.0
lung cancer 0.0
proteinuria 0.0
atherosclerosis -0.1
rheumatoid arthritis -0.1
asthma -0.2
hyperglycemia -0.3
abortion -0.3
carcinoma -0.3
cold -0.3
liver disease -0.3
fits -0.4
autism -0.4
melanoma -0.5
gastric cancer -0.6
lymphoma -0.6
breast cancer -0.7
infectious diseases -0.8
cirrhosis -0.8
multiple sclerosis -0.8
cancer -1.0
colorectal cancer -1.1
plaque -1.1
diabetes -1.2
influenza -1.2
type 2 diabetes -1.2
tumor growth -1.3
adenocarcinoma -1.5
stroke -1.6
ischemia -1.9
metastases -2.1
obesity -2.3
hypertension -2.8
depression -2.8
Symptom
Extrapyramidal symptoms 7.0
chorea 6.4
cerebellar ataxia 5.8
clumsiness 5.5
dystonia 5.5
ataxia 5.3
bradykinesia 5.0
incoordination 3.8
dysarthria 3.7
cachexia 2.1
starvation 2.0
spasticity 1.9
tremor 1.4
hypothermia 0.5
collapse -0.2
seizures -0.7
pain -3.4
Drug
Tora 9.8
K201 9.5
CDX 6.6
CDX 6.2
DNase I 5.9
CIA 5.0
Etoposide 4.4
ETS 4.2
Alanine 4.1
CTA 4.1
Glycyrrhiza 4.1
VCR 4.0
Ranitidine 3.9
-deoxyadenosine 3.6
Gel 3.5
Capsicum 3.4
Glycerol 3.4
Fraction 3.3
MOF 3.0
lysine 3.0
p75 2.7
Adriamycin 2.4
ICI 2.2
FAD 2.2
Ethanol 1.3
Asn 1.1
CSF 0.7
ROS 0.3
caffeine 0.2
IL-2 -0.2
Enzyme
arginyltransferase 9.0
KLK13 8.8
RNA polymerase 8.3
3C protease 8.2
SPT 8.1
histone acetyltransferase 7.9
CTD kinase 7.5
conjugase 7.4
macrophage elastase 7.4
SPT 7.4
methyl coenzyme M reductase 7.2
lambda exonuclease 6.9
pantothenate kinase 6.6
ADH3 6.6
succinic semialdehyde dehydrogenase 6.4
restriction-modification system 6.1
factor D 5.8
O-GlcNAc transferase 5.6
asparagine synthetase 5.6
glyceraldehyde-3-phosphate dehydrogenase 5.5
glyceraldehyde-3-phosphate dehydrogenase 5.5
glyceraldehyde-3-phosphate dehydrogenase 5.4
glyceraldehyde-3-phosphate dehydrogenase 5.4
MTD 5.4
porphobilinogen deaminase 5.3
glyceraldehyde-3-phosphate dehydrogenase 5.2
poly(A) polymerase 5.2
insulin-degrading enzyme 5.1
aldehyde dehydrogenase 4.9
PAT 4.9
tryptophan 2,3-dioxygenase 4.8
sucrase-isomaltase 4.8
KAT 4.8
ALA synthase 4.6
farnesyltransferase 4.6
carboxypeptidase Y 4.2
DNA ligase 4.2
DNA ligase 4.2
micrococcal nuclease 4.1
farnesyltransferase 4.0
glutathione S-transferase 4.0
protein phosphatase 2A 4.0
deoxyribonuclease 4.0
prostate-specific membrane antigen 3.8
S1 nuclease 3.7
MEKK1 3.7
thymidine kinase 3.7
glutaminase 3.7
luciferase 3.7
DNase 3.7
PRE 3.7
dihydrofolate reductase 3.7
glucoamylase 3.5
NADH dehydrogenase 3.5
glutamate dehydrogenase 3.5
glutamate dehydrogenase 3.5
glutamate dehydrogenase 3.5
N-acetyltransferase 3.4
sucrase 3.4
thioredoxin reductase 3.3
invertase 3.3
DNA methyltransferase 3.3
hypoxanthine-guanine phosphoribosyltransferase 3.3
chloramphenicol acetyltransferase 3.3
peroxiredoxin 3.2
cdc2 3.1
firefly luciferase 3.1
ascorbate peroxidase 3.1
ATPase 3.1
ribonucleotide reductase 3.1
ribonucleotide reductase 3.0
glucose-6-phosphatase 3.0
proteasome 2.9
lipoprotein lipase 2.8
nitrogenase 2.8
succinate dehydrogenase 2.6
RNase 2.6
chitinase 2.5
protein kinase 2.5
RNase 2.5
topoisomerase 2.4
endonuclease 2.4
laccase 2.4
transcriptase 2.4
IKK 2.3
MIP 2.3
topoisomerase 2.3
kinesin 2.3
ceruloplasmin 2.3
adenosine deaminase 2.3
adenosine deaminase 2.2
phosphatidylinositol 3-kinase 2.2
ERK 2.1
phosphoinositide 3-kinase 2.1
diaphorase 2.1
NQO1 2.0
caspase-1 2.0
ornithine decarboxylase 2.0
ATP synthase 1.8
beta-glucuronidase 1.7
reverse transcriptase 1.6
DNA polymerase 1.5
complex I 1.5
alcohol dehydrogenase 1.4
protein kinase C 1.3
AMPK 1.0
AMP-activated protein kinase 0.9
thromboplastin 0.9
beta-lactamase 0.9
beta-galactosidase 0.7
focal adhesion kinase 0.7
mitogen-activated protein kinase 0.6
APC 0.6
calcineurin 0.5
MEK 0.4
phospholipase C 0.4
catalase 0.4
phosphodiesterase 0.4
aspartate aminotransferase 0.2
caspase-3 -0.5
renin -0.5
alkaline phosphatase -1.0
superoxide dismutase -1.3
Compound
TBP 10.8
TBP 10.6
TIF 10.1
alpha-Amanitin 8.4
CAA 8.3
TPB 8.2
Molybdenum cofactor 8.2
Nile Blue 7.5
Nile Blue 7.5
ATF 6.8
MGBG 6.6
MGBG 6.6
TEC 6.5
AF-2 6.5
TFE 6.4
Carcinogen 6.4
TET 6.2
TET 6.2
Benzo[a]pyrene 6.1
SP-1 5.8
[1,10]phenanthroline 5.6
Camptothecin 5.4
Camptothecin 5.4
Camptothecin 5.4
DBD 5.3
dUMP 5.2
DAB 5.2
TAR 5.1
glutamine 5.0
Polyamine 5.0
pteridine 5.0
PAT 5.0
DMS 4.9
Histone 4.9
LCR 4.9
AICAR 4.9
MAD 4.9
AAT 4.8
CAN 4.8
NBQX 4.7
GAL 4.7
DRB 4.7
Coumarin 4.7
PSP 4.6
Melanin 4.5
Glycogen synthase 4.4
Lewis X 4.4
methyl methanesulfonate 4.3
APO 4.2
Alanine 4.2
DAMP 4.1
Agarose 4.1
AICAR 4.0
L-threonine 4.0
DNA 3.9
UDP-GlcNAc 3.8
C2H2 3.8
LPC 3.8
COS 3.8
Phorbol 3.6
Genistein 3.6
formaldehyde 3.4
chromate 3.4
Dextran 3.3
Ethylene 3.3
Ubiquitin 3.2
CIT 3.2
40S 3.1
Adenine 3.1
CIT 3.1
formaldehyde 3.1
Nitrite 3.1
AAA 3.1
ADP-ribose 3.1
CAT 3.0
CAT 3.0
VP-16 3.0
CAT 2.9
lysine 2.8
cAMP 2.8
propylene glycol 2.7
alanine 2.7
N-isopropylacrylamide 2.7
Congo red 2.7
proline 2.6
propylene glycol 2.6
retinoic acid 2.6
serine 2.6
ATP 2.5
uridine 2.5
TPA 2.4
DEAE 2.3
THP 2.2
tryptophan 2.2
THP 2.2
APAP 2.2
acetyl-CoA 2.2
threonine 2.2
TPA 2.1
FAD 2.1
glycerol 2.1
asparagine 2.0
leucine 2.0
UDP 2.0
ICI 1.9
pyrimidine 1.9
pyrimidine 1.8
His 1.8
salt 1.8
acridine 1.8
arginine 1.7
glutamic acid 1.6
Adriamycin 1.6
AMP 1.5
adenosylmethionine 1.5
alcohol dehydrogenase 1.5
Optimal 1.5
tryptophan 1.5
tryptophan 1.5
SDS 1.5
tryptophan 1.4
Nicotine 1.4
vitamin D 1.4
NH2 1.4
isopropanol 1.4
AMPA 1.3
zinc 1.3
pyrene 1.3
Phe 1.3
phosphoric acid 1.2
aspartic acid 1.2
aspartic acid 1.2
NADP 1.1
Neuronal 1.1
Gly 1.1
aspartic acid 1.1
Asp 1.1
TEM 1.0
ADP 1.0
ADP 0.9
aspartic acid 0.9
copper 0.9
GlcNAc 0.9
phosphate 0.9
tyrosine 0.8
sulfate 0.8
ADP 0.8
Mg2+ 0.8
xylose 0.7
galactose 0.7
cysteine 0.7
chlorine 0.6
acetate 0.5
vinyl 0.4
hydrogen 0.4
Dec 0.4
methionine 0.3
TOF 0.3
ammonium 0.2
caffeine 0.2
ethanol 0.1
glutamate 0.0
aldosterone -0.0
NAD -0.1
DSM -0.1
methane -0.1
sodium -0.2
potassium -0.4
5-HT -0.4
nitrogen -0.4
glucose -0.4
Pac -0.5
calcium -1.0
nitrate -1.1
urea -1.4
iron -1.5
water -2.0
oxygen -2.3
Clin -3.7