Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P20226 (
TATA-binding protein
)
1,297
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Heterogeneous nuclear ribonucleoprotein F (hnRNP-F) has been shown to be a pre-mRNA splicing factor. Recent studies have uncovered the coordination of synthesis of pre-mRNA and its processing, including post-transcriptional modification and splicing. Here, we present evidence for an association between a
splicing factor
, hnRNP-F, and
TATA-binding protein
(
TBP
), which is an essential factor needed for transcription initiation. An affinity detection experiment revealed hnRNP-F in the preparation of
TBP
-interacting proteins. HnRNP-F was associated with
TBP
in nuclear extracts and was capable of direct binding to
TBP
in vitro. These results suggest that hnRNP-F is associated with
TBP
in the cell. HnRNP-F was observed in abundance in the thymus, spleen and testis, and its distribution pattern was similar to that of
TBP
, implying a functional coordination of transcription and splicing. We assume that the splicing machinery is associated with the transcription apparatus as a prerequisite prior to transcriptional elongation.
...
PMID:Association of the rat heterogeneous nuclear RNA-ribonucleoprotein F with TATA-binding protein. 1047 89
