Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P20226 (
TATA-binding protein
)
1,297
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
TATA-box binding protein
(
TBP
) in a monomeric form and the complexes it forms with DNA have been elucidated with molecular dynamics simulations. Large
TBP
domain motions (bend and
twist
) are detected in the monomer as well as in the DNA complexes; these motions can be important for
TBP
binding of DNA.
TBP
interacts with guanine bases flanking the TATA element in the simulations of the complex; these interactions may explain the preference for guanine observed at these DNA positions. Side chains of some
TBP
residues at the binding interface display significant dynamic flexibility that results in 'flip-flop' contacts involving multiple base pairs of the DNA. We discuss the possible functional significance of these observations.
...
PMID:DNA binding by TATA-box binding protein (TBP): a molecular dynamics computational study. 890 80
