Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P20226 (
TATA-binding protein
)
1,297
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Studies on biological functions of N
6
-methyladenosine (m
6
A) modification in mRNA have sprung up in recent years. We find m
6
A can positively regulate the glycolysis of cancer cells. Specifically, m
6
A-sequencing and functional studies confirm that pyruvate dehydrogenase kinase 4 (PDK4) is involved in m
6
A regulated glycolysis and
ATP
generation. The m
6
A modified 5'UTR of PDK4 positively regulates its translation elongation and mRNA stability via binding with YTHDF1/eEF-2 complex and IGF2BP3, respectively. Targeted specific demethylation of PDK4 m
6
A by dm
6
ACRISPR system can significantly decrease the expression of PDK4 and glycolysis of cancer cells. Further,
TATA-binding protein
(
TBP
) can transcriptionally increase the expression of Mettl3 in cervical cancer cells via binding to its promoter. In vivo and clinical data confirm the positive roles of m
6
A/PDK4 in tumor growth and progression of cervical and liver cancer. Our study reveals that m
6
A regulates glycolysis of cancer cells through PDK4.
...
PMID:N
6
-methyladenosine regulates glycolysis of cancer cells through PDK4. 3244 98
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