Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P20020 (
adenosine triphosphatase
)
3,299
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The highly-purified, oligomycin-sensitive mitochondrial
adenosine triphosphatase
has been reconstituted with phosphatidylserine. Treatment of the phosphatidylserine-reconstituted ATPase with
phosphatidylserine decarboxylase
produced a 3-fold decrease in the specific activity of the resulting phosphatidylethanolamine-enriched ATpase complex. Subsequent control experiments indicated that the resulting phosphatidylethanolamine was responsible for the lowered ATPase specific activity. These observations indicate that acidic phospholips do more than facilitate and interaction between the highly-purified, lipid-depleted ATPase and phospholipid. The negatively charged phospholipid appears to be essential for maintaining high levels of oligomycin-sensitive activity even after the initial interaction between phospholipid and the ATPase complex has occurred.
...
PMID:Negatively charged phospholipid requirement of the oligomycin-sensitive mitochondrial ATPase. 645 1
