Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P20020 (
adenosine triphosphatase
)
3,299
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The possibility that chlorhexidine is a specific inhibitor of membrane bound bacterial
adenosine triphosphatase
(
ATPase
) was addressed. The in-vitro susceptibilities of several Providencia stuartii cell envelope enzymes, including
ATPase
, to chlorhexidine were compared. The following concentrations of chlorhexidine were required to cause 50% inhibition of enzyme activity in preparations from chlorhexidine-sensitive strains (
MIC
50 mg chlorhexidine/l):
ATPase
(160 mg/l), succinic dehydrogenase (greater than 300 mg/l), penicillin binding protein 7 (300 mg/l) and beta-lactamase (45 mg/l). Fifty per cent inhibition of the
ATPase
from a chlorhexidine-resistant strain (
MIC
1600 mg/l) was achieved at an in-vitro concentration of 225 mg chlorhexidine/l. Our observations do not support the suggestion that bacterial membrane-bound ATPases are specific targets for chlorhexidine.
...
PMID:Inhibition of Providencia stuartii cell envelope enzymes by chlorhexidine. 295 30
