Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P20020 (
adenosine triphosphatase
)
3,299
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The conserved histone variant
H2AZ
has an important role in the regulation of gene expression and the establishment of a buffer to the spread of silent heterochromatin. How histone variants such as
H2AZ
are incorporated into nucleosomes has been obscure. We have found that Swr1, a Swi2/Snf2-related
adenosine triphosphatase
, is the catalytic core of a multisubunit, histone-variant exchanger that efficiently replaces conventional histone H2A with histone
H2AZ
in nucleosome arrays. Swr1 is required for the deposition of histone
H2AZ
at specific chromosome locations in vivo, and Swr1 and
H2AZ
commonly regulate a subset of yeast genes. These findings define a previously unknown role for the adenosine triphosphate-dependent chromatin remodeling machinery.
...
PMID:ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. 1472 82
