Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P20020 (adenosine triphosphatase)
 3,299 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Trehalose-6,6'-dicorynomycolate (T66DCM), the cord factor of Corynebacterium diphtheriae, induced in vitro a swelling accompanied with a partially irreversible change of the mitochondrial membrane system in mouse liver. Preincubation of the mitochondrial suspension with T66DCM resulted in an inhibition of phosphorylation coupled to the oxidation of either succinate or a number of reduced nicotinamide adenine dinucleotide-linked substrates and a loss of respiratory control. T66DCM affected both electron transport and phosphorylation at coupling site II and uncoupled respiration and phosphorylation at coupling site III. T66DCM stimulated mitochondrial adenosine triphosphatase. The induction of adenosine triphosphatase by T66DCM and by 2,4-dinitrophenol was additive.
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PMID:Site of action of the cord factor of Corynebacterium diphtheriae in mitochondria. 425 39

A monoester of trehalose linked at the 6-position with mycolic acids (trehalose-6-monomycolate) was isolated from the wax D fraction of virulent human Mycobacterium tuberculosis, and its biochemical action on host-cell mitochondria was studied. Trehalose-6-monomycolate showed a delayed toxicity for mice. The 50% lethal dose at 2 weeks was 452 mug. It induced in vitro a swelling of mouse liver mitochondria and uncoupled respiration and phosphorylation in the nicotinamide adenine dinucleotide pathway of the electron transport chain. The site of functional damage was located specifically at coupling site II. Mitochondrial adenosine triphosphatase was slightly stimulated by trehalose-6-monomycolate. These findings indicate that trehalose-6-monomycolate affects mitochondrial oxidative phosphorylation in a similar manner to, but to a lesser extent than, trehalose-6, 6'-dimycolate (cord factor) of M. tuberculosis.
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PMID:Isolation and biochemical activities of trehalose-6-monomycolate of Mycobacterium tuberculosis. 427 21