Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P20020 (adenosine triphosphatase)
 3,299 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 6 x 3 factorial laboratory experiment was conducted to study the effects of acid and alkaline stress (pH 5.0, 6.0, 7.0, 8.0, 9.0, and 10.0) on the oxygen consumption rate (OR), ammonia excretion rate (NR), and lactate dehydrogenase (LDH) and Na+ -K+ adenosine triphosphatase (Na+ -K+ ATPase) activities of Oreochromis niloticus juveniles with body mass 1.02, 5.13, and 10.31 g. With increasing pH, the juveniles OR and NR increased first, peaked at pH 7.0-8.0, and decreased then. The OR and NR increased with increasing body mass, and their relationships fitted power equations. The linear effects of pH and body mass and the quadratic effect of pH on the OR and NR were highly significant (P < 0.01), but the pH and body mass had less synergistic effect on the OR and NR (P > 0.05). Regressive equations of pH and body mass with the OR and NR were established, the R2 being 0.942 and 0.936, respectively (P < 0.01). Body mass had significant effects on the O:N ratio (P < 0.01), whereas acid and alkaline stress could alter the energy source utilization patterns of the juveniles. High pH was not favorable to the LDH activity, but favorable to the Na+ -K+ ATPase activity. The pH had linear and quadratic effects on the LDH and Na+ -K+ ATPase activities (P < 0.01), body mass had no significant effect on the Na+ -K+ ATPase activity, and the pH and body mass had no synergistic effect on the two enzyme activities (P > 0.05).
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PMID:[Effects of acid and alkaline stress on energy metabolism of Oreochromis niloticus juveniles with different body mass]. 2212 60

Genistein (4',5,7-trihydroxyisoflavone) is naturally present in plants of the soy family and is known to have various pharmacological activities, such as anti-cancer, anti-diabetic, anti-oxidant, etc. The phytoestrogen is one of the major isoflavones found in some medicinal plants having anthelmintic properties. This review describes the putative role of genistein as an anthelmintic, which has been tested on some helminth parasites in vitro. Genistein has been shown to cause paralysis and alterations in the tegument and tegumental enzymes (acid phosphatase, alkaline phosphatase, adenosine triphosphatase, and 5'-nucleotidase) of helminth parasites. Alterations in the activities of several enzymes associated with the coordination system (specifically non-specific esterases, acetylcholine esterase, and nitric oxide synthase), and changes in the concentration of nitric oxide, cGMP, free amino acid pool, and tissue ammonia are observed in helminth parasites treated with genistein. The phytoestrogen also affects the carbohydrate metabolism by altering the activities of key enzymes involved in glycogen- and glucose-metabolism of a cestode parasite. Considering the significance of phosphoenolpyruvate carboxykinase (PEPCK) in glycolysis of the cestode parasite, Ki of the phytoestrogen for PEPCK in the parasite has been determined, and molecular docking of genistein into the active site of the enzyme has also been described. The potential beneficial role of genistein as a natural alternative in management of helminth parasites needs to be further explored, particularly considering its in vivo efficacy and pharmacokinetics.
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PMID:Genistein: is the multifarious botanical a natural anthelmintic too? 2984 17


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