Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P20020 (adenosine triphosphatase)
 3,299 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The morphology of the tongue muscles was studied by in situ dissection as well as by histological and histochemical methods. By means of the latter an anatomical reassessment of attachments and fiber courses was made. The histochemistry was studied in sections stained for myofibrillar adenosine triphosphatase (mATPase), succinic dehydrogenase, NADH diaphorase, phosphorylase, esterase, glycogen and lipids. Fibers of type I and type II were identified, and the latter were subdivided into II1 (highly glycolytic), II12 (intermediately glycolytic and lipolytic) and II123 (highly lipolytic). In the extrinsic muscles, the fibers were 19-25% type I (mean diameter 27 micrometers) and 75-81% type II (37 micrometers); the three type II subgroups appeared in equal proportions, each accounting for 22-30% of the total fiber amount. Pars longitudinalis superior m. hyoglossi and pars longitudinalis inferior m. styloglossi contained only type II fibers, mainly type II12 (67% and 46%, respectively), of diameters like those in m. hyoglossus and m. styloglossus. The intrinsic muscles also consisted entirely of type II fibers (23 micrometers). II123 fibers predominated in m. verticalis (83%), which has only 10% H12 and 6% II1, whereas the fiber composition of m. transversus was more balanced: 37% type II1, 32% II12 and 31% II123.
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PMID:Morphological and histochemical properties of tongue muscles in cat. 645 24

Breast cancer 1, early onset (BRCA1)-interacting protein 1 (BRIP1), a DNA-dependent adenosine triphosphatase and DNA helicase, is required for BRCA-associated DNA damage repair functions, and may be associated with the tumorigenesis and aggressiveness of various cancers. The present study investigated the expression of BRIP1 in normal cervix tissues and cervical carcinoma via reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and immunohistochemistry assays. BRIP1 expression was observed to be reduced in squamous cancer tissue and adenocarcinoma compared with normal cervix tissue, and there were significant correlations between the reduction in BRIP1 expression and unfavorable variables, including the International Federation of Gynecologists and Obstetricians stage and presence of lymph node metastases. In order to elucidate the role of BRIP1 in cervical cancer, a BRIP1 recombinant plasmid was constructed and overexpressed in a cervical cancer cell line (HeLa). The ectopic expression of BRIP1 markedly inhibited the tumorigenic properties of HeLa cells in vitro, as demonstrated by decreased cell growth, invasion and adhesion, and increased cell apoptosis. In addition, it was identified that the inhibitory tumorigenic properties of BRIP1 may be partly attributed to the attenuation of RhoA GTPase activity. The present study provides a novel insight into the essential role of BRIP1 in cervical cancer, and suggests that BRIP1 may be a useful therapeutic target for the treatment of this common malignancy.
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PMID:BRIP1 inhibits the tumorigenic properties of cervical cancer by regulating RhoA GTPase activity. 2687 Feb 46