Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P20020 (
adenosine triphosphatase
)
3,299
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
1. Cystamine (2,2'-diaminodiethyl disulphide) caused an unmasking of mitochondrial
adenosine triphosphatase
and a leakage of Mg(2+) from the mitochondria, and decreased the stimulation of
adenosine triphosphatase
by 2,4-dinitrophenol. When Mg(2+) was added, cystamine potentiated the activation of
adenosine triphosphatase
by 2,4-dinitrophenol. 2. Cystamine was without effect on the
adenosine triphosphatase
of disrupted mitochondria. 3. Cystamine was moderately potent as an uncoupling agent and as an inhibitor of the [(32)P]P(i)-ATP exchange reaction. 4.
Cysteamine
(
2-aminoethanethiol
) was without the above effects, when special precautions were taken to counteract its autoxidation. 5. The effects of cystamine should probably be ascribed to its disulphide group, since the diamine cadaverine protected slightly against the loss of Mg(2+) and the decrease of 2,4-dinitrophenol-stimulated adenosine-triphosphatase activity caused by aging of the mitochondria. It is suggested that cystamine acts by a breakdown of mitochondrial permeability barriers.
...
PMID:Effects of cystamine and cysteamine on the adenosine-triphosphatase activity and oxidative phosphorylation of rat-liver mitochondria. 422 34
