Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P20020 (
adenosine triphosphatase
)
3,299
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The inhibition of canine renal sodium potassium
adenosine triphosphatase
(
ATPase
) by neomycin was examined.
Neomycin
inhibited
ATPase
nearly maximally at 0.02 mM. The inhibition was temperature dependent with a decrease in inhibition occurring at temperatures below 21 degrees C, a temperature which corresponded to a change in activation energy of the
ATPase
as determined by Arrhenius plot. Preincubation of the
ATPase
with phosphoinositides was found to prevent the inhibition by neomycin. Other phospholipids were not found to prevent the inhibition. These results indicate a possible interaction between neomycin and the phosphoinositides of the
ATPase
complex.
...
PMID:Neomycin inhibition of adenosine triphosphatase: evidence for a neomycin-phospholipid interaction. 644 4
