Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P20020 (adenosine triphosphatase)
 3,299 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A total of 18 white Water female rats weighing 180-200 gm were included in the experiment. 9 rats each received 1 ml of Ovral tablets that had been pulverized for suspension in 100 ml of water, and 9 served as controls. The Na+, K+-adenosine triphosphatase (ATP ase) activity of the liver membrane was measured in both groups from the 6th month. The ATPase plasma membrane activity of 8 control rats averages 6.9 micro mol Pi/mg prot/15 minutes. In rats taking Ovral the activity of total APTase averaged 6.3 +or- micro mol P1/mg protein not significantly deviating from the norm. However, in these rats the Na+, K+-ATPase activity averaged 7.7 +or- 3.1 micro mol Pi/mg prot/15 minutes, while in controls the Na+, K+ - ATP ase activity averaged 6.2 +or- 5.2 micro mol Pi/mg prot/165 minutes. The difference between the 2 groups was significant (p M .01), apparently the inhibition of Na+, K+ - ATP ase activity in rats taking Ovral occurred. The mechanism of the clinical pathogenesis of cholestasis in the liver of women taking oral contraceptives is probably attributable to this effect.
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PMID:[The mechanism of intrahepatic cholestasis induced by oral contraceptives]. 1228 68

Population declines of wild Atlantic salmon have been attributed to an array of anthropogenic disturbances, including dams, commercial and recreational fishing, habitat loss, and pollution. Environmental contaminants in particular, can act as environmental stressors on fish, typically causing disruption of ion homeostasis due to their close association with the aquatic environment. To examine the effects of the xenoestrogen 4-nonylphenol (NP) or 17beta-estradiol (E2) on stress sensitivity and ion regulation, we exposed juvenile Atlantic salmon continuously for 21 d to either 10 or 100 microg/L NP (NP-L or NP-H), 2 microg/L E2 (positive control), or vehicle control during the parr-smolt transformation in April. After treatment, fish were sampled in freshwater (FW), transferred to 30 per thousand seawater (SW) for 24 h, or subjected to a handling stress. Estradiol and NP-H increased plasma vitellogenin in males and females, and E2 increased gonadosomatic index only in males. In FW, E2 reduced sodium potassium-activated adenosine triphosphatase activity as well as plasma levels of growth hormone, insulin-like growth factor I, and triiodothyronine. Both E2 and NP-H reduced plasma sodium in FW and increased plasma chloride in SW. Plasma cortisol levels pre- and poststressor were significantly elevated by all treatments relative to controls, but only E2 increased plasma glucose before and after the stressor. These results indicate that exposure of anadromous salmonids to environmental estrogens heightens sensitivity to external stressors, impairs ion regulation in both FW and SW, and disrupts endocrine pathways critical for smolt development.
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PMID:Aqueous exposure to 4-nonylphenol and 17beta-estradiol increases stress sensitivity and disrupts ion regulatory ability of juvenile Atlantic salmon. 1766 83