Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P20020 (
adenosine triphosphatase
)
3,299
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The localization of the Mg++-activated
adenosine triphosphatase
(
ATPase
) in the human
Fallopian tube
has been studied by means of histochemical methods. The samples were obtained from 18 women, 23-62 years of age, treated by different steroid hormones. Endosalpinx ciliary
ATPase
-activity represents dynein and is therefore an indicator of ciliary motility. Estrogens and gestagens have a different influence on
ATPase
activity. All cilia of 1 ciliated cell react in the same manner and may be regarded as a reaction unit. The relation of negative to positive ciliary borders differs characteristically in the tubal isthmus, ampulla, and infundibulum and coincides with commonly known phenomena of egg transport through the oviduct. Postovulatory, reaction units increase in ampulla and infundibulum compared with the proliferative phase. The oviducts of postmenopausal women possess very few reaction units. Short-term treatment with estrogen in the early secretory phase results in a great number of reaction units in all tubal segments; a similar treatment in the proliferative phase diminishes the reaction units in the ampulla. Midcycle progesterone treatment activates the ciliary
ATPase
in the isthmus. Low doses of lynestrenol (minipill) in the proliferative phase leads to a decrease of reaction units in all tubal segments; the pattern of ciliary reaction under low doses of lynestrenol at the time of ovulation coincides with that of the proliferative phase. Treatment with a contraceptive steroid (.05 mg ethinyl estradiol and .025 d-norgestrel) causes a considerable activation of the ciliary
ATPase
in all portions of the oviduct.
...
PMID:[Histochemical and histological investigations on the human fallopian tube under different hormonal influences. I. Demonstration of ATPase with special reference to reactive ciliated cells (author's transl)]. 13
