Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P20020 (adenosine triphosphatase)
 3,299 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. The relationship between response of the heart to increased stimulation frequency and digitalis sensitivity was examined comparing the positive inotropic effect of strophanthidin and [3H]ouabain binding to sarcolemmal Na+, K+-activated adenosine triphosphatase (Na+, K+-ATPase) in carp heart, which showed a negative force-frequency relationship, and in guinea-pig heart, which has a positive relationship. 2. In ventricular muscle preparations isolated from carp heart, strophanthidin increased developed tension with a half-maximal effect observed at 0.31 microM, indicating a relatively high digitalis sensitivity of this preparation. 3. The positive inotropic effect was not altered by concentrations of propranolol sufficient to block beta-adrenergic receptors. 4. Specific binding of [3H]ouabain to homogenates obtained from ventricular muscle of carp heart showed a single class of binding sites with a Kd value of 26 nM. 5. Potency of strophanthidin to produce the positive inotropic effect and affinity of the binding sites for [3H]ouabain were both higher in carp heart compared to those in guinea-pig heart. 6. These results demonstrate a clear dissociation between the force-frequency relationship and the sensitivity of heart muscle to the positive inotropic effect of cardiotonic steroids. 7. The latter is primarily determined by affinity of sarcolemmal Na+, K+-ATPase for the cardiotonic steroids.
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PMID:Carp (Cyprinus carpio) heart has a high sensitivity to the positive inotropic effect of strophanthidin despite negative force-frequency relationships. 282 23

In this study, an attempt has been made to compare the most common species of tapeworms in carp: non-segmentary Khawia sinensis and segmentary Bothriocephalus acheilognathi on the basis of histoenzymatic examination of 8 enzymes, i.e. alkaline phosphatase, acid phosphatase, adenosine triphosphatase, nonspecific esterase alfa, succinic dehydrogenase, lactate dehydrogenase, leucine aminopeptidase and gamma-glutamylo transferase.
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PMID:[Localization and activity of several enzymes in tissues of Bothriocephalus acheilognathi and Khawia sinensis tapeworms parasitizing carp]. 823 9

The effect of exposure to sublethal concentrations of the organophosphate pesticide, quinalphos (1.12, 0.22 mg/l) on biochemical parameters of muscle and enzyme activities in brain, liver and kidney of the Indian major carp, Labeo rohita was studied after 15, 30 and 45 days. The muscle protein and RNA levels decreased whereas DNA levels and acid phosphatase were elevated. Similarly, alkaline phosphatase was depleted. The brain acetyl cholinesterase activity was decreased most (-75.43%) in 1.12 mg/l concentration over a period of 45 days. Lactic dehydrogenase levels in brain and liver were elevated whereas in the kidney they were inhibited. Succinic dehydrogenase and adenosine triphosphatase activities were depleted in brain, liver and kidney. The effects have been discussed for different organ tissues in relation to the pesticide.
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PMID:Chronic toxic effects of quinalphos on some biochemical parameters in Labeo rohita (Ham.). 1071 64

A method for the determination of adenosine triphosphatase (ATPase) activity of myofibrils of big head carp by using ion chromatography was introduced. Adenosine triphosphate (ATP), adenosine diphosphate (ADP) and orthophosphate (Pi) were separated completely. Recoveries for ATP, ADP and Pi were 98+/-5%, 97+/-4% and 98+/-5%, respectively. Pi liberated from ATP during reaction was monitored by ion chromatography using the suggested method. This method was applicable to the determination of myofibrils ATPase activity for quick quality evaluation of surimi.
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PMID:Determination of the big head carp myofibrillar (Aristichthys nobilis) adenosine triphosphatase activity by ion chromatography. 1670 79

A 60-day experiment was carried out to study the effect of sub-lethal concentration of cypermethrin (1/10th of LC(50)) exposure on haematological and biochemical parameters of the Indian major carp, Catla catla fingerlings. Under exposure, the total erythrocyte count, total leucocyte count, haemoglobin content and haematocrit were decreased. All the studied serum parameters viz. total serum protein, albumin, globulin contents and albumin-globulin ratio were significantly decreased in cypermethrin-exposed fishes. A marked increase was recorded in alanine aminotransferase and aspartate aminotransferase activities in liver, whereas lactate dehydrogenase activity of muscle and acetylcholine esterase activity in brain were inhibited in cypermethrin-exposed fish. The membrane transport enzymes (total adenosine triphosphatase, sodium-potassium adenosine triphosphatase and magnesium adenosine triphosphatase) activities were decreased significantly in the gills of C. catla exposed to sub-lethal concentration of cypermethrin. The present study indicates that sub-lethal exposure of C. catla fingerlings to cypermethrin alters the haematological and biochemical parameters.
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PMID:Alteration in haematological and biochemical parameters of Catla catla exposed to sub-lethal concentration of cypermethrin. 2258 Sep 24

Nano-selenium (Se), with its high bioavailability and low toxicity, has attracted wide attention for its potential application in the prevention of oxidative damage in animal tissues. However, the effect of nano-Se of different sizes on the intestinal epithelial cells of the crucian carp (Carassius auratus gibelio) is poorly understood. Our study showed that different sizes and doses of nano-Se have varied effects on the cellular protein contents and the enzyme activities of secreted lactate dehydrogenase, intracellular sodium potassium adenosine triphosphatase, glutathione peroxidase, and superoxide dismutase. It was also indicated that nano-Se had a size-dependent effect on the primary intestinal epithelial cells of the crucian carp. Thus, these findings may bring us a step closer to understanding the size effect and the bioavailability of nano-Se on the intestinal tract of the crucian carp.
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PMID:Effect of selenium nanoparticles with different sizes in primary cultured intestinal epithelial cells of crucian carp, Carassius auratus gibelio. 2420 37