Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P17931 (
galectin-3
)
2,860
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In this retrospective histologic study,
galectin-3
had a sensitivity of 92% (22/24) for papillary thyroid carcinoma and 44% (4/9) for follicular thyroid carcinoma.
Thyroid peroxidase
(
TPO
) had a sensitivity of 50% (12/24) for papillary and 11% (1/11) for follicular carcinoma. The combination of
galectin-3
and
TPO
had a sensitivity of 96% (23/24) for papillary and 44% (4/9) for follicular carcinoma. From a prognostic standpoint, of patients whose papillary carcinomas expressed both markers, all became free of disease. Of those whose papillary carcinomas expressed
galectin-3
but not
TPO
, 57% (4/7) became free of disease, 29% (2/7) had persistent disease, and 14% (1/7) had progressive disease. This study confirms previous observations that
galectin-3
alone is highly sensitive for papillary carcinoma but not adequately sensitive for follicular carcinoma.
TPO
alone is not adequately sensitive for the evaluation of any thyroid lesion. The combination of
galectin-3
and
TPO
is complementary as a diagnostic and prognostic tool for patients with papillary carcinoma.
...
PMID:The use of a combination of galectin-3 and thyroid peroxidase for the diagnosis and prognosis of thyroid cancer. 1548 49
