Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P17931 (galectin-3)
 2,860 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Type 2 diabetes mellitus (T2DM) remains substantial health problem and one of the most prevalent metabolic diseases worldwide. The impact of T2DM on CV mortality and morbidity is embedded through a nature evolution of the disease and is modulated by numerous risk factors, such as hypertension, obesity, dyslipidemia. There is large body of evidence regarding use of the cardiac biomarkers to risk stratification at higher CV risk individuals who belongs to general population and cohort with established CV disease. Although T2DM patients have higher incidence of cardiac and vascular complications than the general population, whether cardiac biomarkers would be effective to risk stratification of the T2DM is not fully understood. The aim of the review is to summarize our knowledge regarding clinical implementation of cardiac biomarkers in risk assessment for T2DM patients. The role of natriuretic peptides, soluble ST2, galectin-3, growth differentiation factor-15, and cardiac troponins are widely discussed.
 ...
PMID:Prognostication of clinical outcomes in diabetes mellitus: Emerging role of cardiac biomarkers. 3133 58

Objective of the study was to determine the correlation between plasma levels of galectin-3 and aldosterone and the dependence of their levels on different clinical characteristics in patients of young and middle age with stage 2 arterial hypertension. 160 male and female patients (80 persons of each gender) with stage 2 hypertension, regardless of the degree, and 27 relatively healthy persons were examined by determining the levels of galectin-3 and aldosterone in blood serum of the main and control groups of the examined persons. The absence of a statistically significant correlation (n=27, R=-0.28, p=0.16) between galectin-3 and aldosterone levels in generally healthy individuals was proved, and the presence of a direct correlation of the average strength between the level of neurohormones (n=160, R=0.64, p<0.0001) in patients of young and middle age with stage 2 hypertension was shown. In addition, the fact of fundamental differences in the nature of associations distribution with the similar level of galectin-3 and aldosterone was demonstrated: in patients with stage 2 and 3 AH as compared to patients with stage 1 AH; in patients with abdominal obesity as compared to patients with normal weight; in patients with dyslipidemia as compared to normal level of proatherogenic lipids. Positive correlation between association with a high level of galectin-3 and aldosterone with the presence of dyslipidemia (R=0.24, p=0.03), high degree of AH (R=0.30, p=0.01), an increase in the total number of risk factors (R=0.45, p<0.0001) and abdominal obesity (R=0.72, p<0.0001) was determined.
 ...
PMID:NATURE OF CORRELATIONS AND DEPENDENCE OF PLASMA CONCENTRATIONS OF GALECTIN-3 AND ALDOSTERONE ON DIFFERENT CLINICAL CHARACTERISTICS IN MALE AND FEMALE PATIENTS WITH ARTERIAL HYPERTENSION. 3201 Dec 99