Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P17931 (
galectin-3
)
2,860
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The success of a pregnancy relies on moderate trophoblast apoptosis. If the 'inhibition-induction' balance of apoptosis is broken, a pathological pregnancy may occur.
Galectin-3
has an important role in numerous biological processes, including tumor cell apoptosis. However, the association between
galectin-3
and
missed abortion
(MA) has remained elusive. In the present study, the mRNA and protein expression levels of
galectin-3
in placental villi, and the apoptotic index of placental cells from patients with MA were assessed and compared with those in a normal spontaneous abortion group. The present study investigated the function of
galectin-3
in the process of MA and the possible association between placental apoptosis and
galectin-3
expression in MA patients. Furthermore, the role of galetin-3 in patients with MA at different times (<4 and >4 weeks) was explored. The present study provided a potential mechanism of MA from a perspective of apoptosis and also provided potential therapeutic approaches to prevent MA.
...
PMID:Expression of galectin-3 and apoptosis in placental villi from patients with missed abortion during early pregnancy. 3090 54
