Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P17174 (aspartate aminotransferase)
 14,872 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of soman poisoning on hematological (counts of red blood cells (RBC), white blood cells (WBC), and platelets and measurement of hematocrit) and coagulation parameters (prothrombin time, activated partial thromboplastin time, thrombin time and concentrations of fibrinogen, factor V, factor VII, and factor XI) and serum biochemistry (concentration of albumin, protein, calcium, cholesterol, triglycerides, blood urea nitrogen (BUN), magnesium, and creatinine and activities of alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, cholinesterase, creatinine phosphokinase (CPK), hydroxybutyrate dehydrogenase, and amylase) were determined at 1, 2, 4, 24, and 48 hours after poisoning of rabbits. There were significant (p less than 0.05) decreases in the RBC counts in all treatment groups that were measured initially at 4 hours and were reflected by parallel decreases in the hematocrit values. These changes were probably due to an increase in the hemolysis of the RBC rather than a decrease in the production of RBC. There were minor changes in the coagulation parameters. Generally, the fibrinogen content increased. The activated partial thromboplastin time decreased significantly (p less than 0.05) 24 and 48 hours after soman (50 micrograms/kg) poisoning. Blood cholinesterase values were significantly reduced in all treatment groups at all time periods. The CPK activity was increased after 4 and 24 hours in the 20 and 50 micrograms/kg soman groups. There were minor changes in the other biochemistry values, but none that showed a dose-response relationship; thus, they were considered to be of limited significance with regard to the toxic manifestations of soman exposure.(ABSTRACT TRUNCATED AT 250 WORDS)
Mil Med 1990 Jun
PMID:Effects of soman poisoning on hematology and coagulation parameters and serum biochemistry in rabbits. 212 98

To better direct screening for preeclampsia, we describe the result trends of the laboratory tests used in the workup of preeclampsia at our institution. The clinical characteristics of patients with abnormal test results are further detailed. The objective of the study is to recommend a laboratory screening regimen for preeclampsia based on the data. All patients who delivered at National Naval Medical Center from February to July 1996 who had blood urea nitrogen, creatinine, aspartate aminotransferase, alanine aminotransferase, or uric acid determinations as part of a workup for preeclampsia were identified. Results are reported, and the clinical characteristics of patients with abnormal tests were obtained from the medical record. Abnormalities of uric acid and liver enzymes were few in our patient population (6% and 7%, respectively). The majority of patients with abnormal uric acid and liver function tests had the classic clinical symptoms of preeclampsia; therefore, the laboratory data added little to the clinical diagnosis. There was a high rate of renal test abnormalities, necessitating further investigation. We recommend omitting liver function and uric acid testing in the routine screening for preeclampsia. The high incidence of abnormal renal tests warrants continued use of this screening test and, more importantly, further investigation into the relationship between abnormal renal tests and disease course.
Mil Med 2000 Jul
PMID:Laboratory testing for preeclampsia: result trends and screening recommendations. 1092 Jun 56

This study examines a method to rapidly rewarm the core using total liquid ventilation with warmed, oxygenated perfluorocarbon. Yucatan miniswine were splenectomized and surgically implanted with telemetry devices to transmit electrocardiographic response, arterial pressure, and core temperature. Hypothermia (core temperature = 25.9 +/- 1.3 degrees C) was induced by placing cold-water circulating blankets over the animals. Control animals (N = 7) were rewarmed using warm (37.8 degrees C), humidified oxygen. Experimental animals (N = 6) were rewarmed with oxygenated perfluorocarbon liquid (37.3 degrees C). The time to rewarm was significantly shorter in experimental animals (1.98 +/- 0.5 vs. 8.61 +/- 1.6 hours, p < 0.0001), with almost no afterdrop in the experimental group. Lactate dehydrogenase and aspartate aminotransferase were significantly increased in the control animals compared with the experimental animals. All animals that survived being chilled to 25 degrees C survived rewarming. This method may provide a means of more rapidly rewarming profoundly hypothermic victims while reducing the risks associated with current methods.
Mil Med 2001 Oct
PMID:Comparison of oxygenated perfluorocarbon and humidified oxygen for rewarming hypothermic miniswine. 1160 34