Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P17174 (aspartate aminotransferase)
 14,872 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of vitamin A on experimental hepatic fibrosis in rats induced by administration of carbon tetrachloride (CCl4) and pig serum was studied. Vitamin A content in the CCl4-induced cirrhotic liver decreased significantly. Administration of pig serum caused hepatic fibrosis without hepatocytic damage. Vitamin A suppressed induction of experimental hepatic fibrosis by CCl4 and pig serum. Neither hepatocytic injury nor increased activities of serum aspartate aminotransferase and glutamic pyruvic transaminase induced by CCl4 was diminished by vitamin A. These data provide evidence that vitamin A inhibits hepatic fibrogenesis and that this effect may be mediated by an action on stellate cells rather than hepatocytes.
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PMID:Suppression of experimental hepatic fibrosis by administration of vitamin A. 257 84

Two milk feeding systems were investigated as influencing the health and development of calves. After the termination of colostrum feeding, the ten animals of the experimental group were given whole milk whereas the control group (also ten calves) was given the Laktosan milk replacer. By the age of three months, blood was collected from the calves for biochemical examination in weekly intervals, later once a month. The content of urea, determined in the blood plasma of the calves of the experimental group was significantly lower in the fourth to seventh week. The plasma levels of nitrogen, potassium, calcium and magnesium were about the same in the experimental and control groups, being within the limits of the reference values. At the age of six to nine weeks, the content of inorganic phosphorus in the blood plasma of the tested animals was statistically significantly higher. Vitamin A concentration in the blood plasma was about the same in both groups. The content of vitamin E in the blood plasma of the calves of the experimental group was statistically significantly higher in the fourth to eight week of age. No significant differences between the two groups were observed in the plasmatic activities of aspartate aminotransferase (AST) and gamma-glutamyl transferase (GMT). The activities of alkaline phosphatase (ALP) were significantly higher in the third to fifth week of life. From the fifth to eighteenth week of age, the average daily weight gains were significantly higher in the calves given whole milk.
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PMID:[The effect of the use of milk-based feed mixtures and whole milk on the development of selected indicators in the blood plasma in calves]. 308 69

Serial nutritional assessments using arm anthropometry, computed tomography of the thigh, and serum biochemical indexes during an eight-month period were performed on nine children with short-bowel syndrome receiving home parenteral nutrition. The mean patient age at the beginning of the study was 3.0 years. In anthropometric measurements, the mean body weight of our test population did not deviate from that of the normal population. Most patients were below the normal median for height. The mean midarm muscle area was 114% of the normal median, and the mean midarm fat area was 98% of the normal median. The mean weight and height velocities were 148% and 122% of the standard, respectively. Retinol-binding protein values, albumin levels, and total lymphocyte counts of the patients were low, while levels of aspartate aminotransferase and alanine aminotransferase were slightly elevated. Midarm muscle and fat compartment sizes were highly correlated with thigh muscle and fat compartment sizes, as demonstrated by computed tomography. Our results demonstrate that children with short-bowel syndrome receiving home parenteral nutrition can maintain normal growth characteristics and extremity compartment sizes.
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PMID:Nutritional assessment of children with short-bowel syndrome receiving home parenteral nutrition. 311 87

A comparative study was conducted to assess the biochemical effects of a low-estrogen combined OC (oral contraceptive). The focus of the study was on possible biochemical effects indicative of altered nutritional status. Both low and high income women on pills were compared with others not on pills. The groups were further divided according to the duration of OC usage. Blood hemoglobin, serum Vitamin A, plasma ascorbic acid, folic acid, riboflavin, and aspartate transaminase levels were measured. Higher income women had better measures on all the indices than the low income women, indicating a better initial nutritional status. Deficiencies increased with duration of use. Results of the study show that OCs reduce the vitamin nutritional level in women. For poor women on OCs, special nutrition intervention programs should be instituted.
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PMID:Vitamin nutritional status of women using oral contraceptive pills. 1226 95

The effect of an acyclic synthetic retinoid analogue NIK-333, on the restoration of liver mass and recovery of liver function after 70% partial hepatectomy, was compared with natural retinoids in rats in vivo. NIK-333 (0.4 mg/kg/day, p.o.)- and all-trans-retinoic acid (ATRA: 4 mg/kg/day, p.o.)-treated rats showed an approximately 1.3- and 1.2-fold increase in liver-to-body weight ratio, respectively, compared to solvent-administered control rats on day 3 after 70% partial hepatectomy. Accordingly, 5-bromo-2'-deoxyuridine (BrdU)-labeling index in the regenerating liver was significantly higher in NIK-333- and ATRA-treated rats compared with control rats on days 0.5 and 1. However, retinol (40 mg/kg/day, p.o.) did not significantly increase either the liver-to-body weight ratio or the BrdU labeling index. In control rats, liver-related serum transaminase activities such as alanine aminotransferase and aspartate aminotransferase, were rapidly elevated on day 1 and then decreased to near pre-operative levels on day 5 following 70% partial hepatectomy. NIK-333 significantly lowered serum transaminases on days 1 and 3 after 70% partial hepatectomy compared with solvent-administered control rats. The transaminase-lowering effect of NIK-333 was more effective than that of ATRA. Retinol did not significantly decrease serum transaminases compared with the control. These results demonstrate that of the three retinoids, NIK-333 was the most potent in promoting the regeneration of liver mass and function with full recovery after 70% partial hepatectomy.
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PMID:Acyclic retinoid NIK-333 accelerates liver regeneration and lowers serum transaminase activities in 70% partially hepatectomized rats, in vivo. 2061 57

Vitamin A is beneficial in counteracting free radical damage, therefore the present study is designed to investigate the effect of vitamin A against isoproterenol-induced myocardial infarction in rats. Male Wistar rats were divided into three groups, namely a normal control group, an isoproterenol group (150 mg/kg, s.c.), and a vitamin A treatment (4,500 IU/kg/d, orally) group. Vitamin A-treated rats demonstrated significant reduction in ST-segment (p<0.001) and infarct sizes (p<0.05) when compared with the isoproterenol group of rats, suggesting that vitamin A markedly attenuated myocardial injury. Vitamin A treatment resulted in a significant decrease in the serum level of troponin I (p<0.001), creatinine kinase-MB (p<0.01), creatine kinase (p<0.05), lactate dehydrogenase (p<0.05), aspartate aminotransferase (p<0.01) and alanine aminotransferase (p<0.01). Vitamin A treatment resulted in a significant decrease in malondialdehyde (p<0.001), and significant increases were observed in reduced glutathione (p<0.01), superoxide dismutase (p<0.05) and catalase (p<0.001). Vitamin A treatment resulted in a significantly increased level of Na(+)-K(+) ATPase (p<0.05) and Mg(2+)-ATPase (p<0.01) and a significant reduction of Ca(2+) ATPase (p<0.01). Vitamin A treatment also demonstrated a significantly decreased level of C-reactive protein (p<0.05) and myeloperoxidase activity (p<0.01). In conclusion, vitamin A attenuated the myocardial infarction and prevention was shown via membrane stabilization, reduction in oxidative stress, and prevention of neutrophil infiltration.
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PMID:Cardio protective effect of vitamin A against isoproterenol-induced myocardial infarction. 2341 98