Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P17174 (aspartate aminotransferase)
 14,872 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thirty-one patients with severe gram-negative bacterial infections were treated successfully with a combination of cefamandole nafate plus gentamicin or tobramycin. The patients were divided into two treatment groups: group 1 received low-dose therapy (80--100 mg of cefamandole nafate/kg per 24 hr plus 3 mg of either gentamicin or tobramycin/kg per 24 hr), and group 2 patients, who had suspected bacteremia, received high-dose therapy (170 mg of cefamandole nafate/kg per 24 hr plus 5 mg of either gentamicin or tobramycin/kg per 24 hr). All of the patients were clinically and bacteriologically cured of their primary infections. All four episodes of bacteremia were cleared within 24 hr after therapy was initiated. There was a uniform decrease in the rate of creatinine clearance which was slightly greater in group 2 patients; however, all creatinine clearance values were within the normal range and actually improved during therapy. There was no difference between the clearance values of the tobramycin-treated patients and gentamicin-treated patients. A few transient abnormalities in results of liver function tests occurred during the study. In one patient whose serum was positive for hepatitis-associated antigen, the alkaline phosphatase, aspartate aminotransferase, and bilirubin values were elevated on admisssion of the patient to the hospital, increased fivefold during therapy, and decreased to the base-line admission values six days after therapy; however, it is difficult to establish that this reaction was antibiotic-induced hepatic toxicity.
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PMID:Efficacy and safety of cefamandole plus either gentamicin or tobramycin in therapy of severe gram-negative bacterial infections. 34 93

Hyperuricaemia was present in 18 out of 73 men with untreated mild hypertension and was related significantly to alcohol intake, serum aspartate transaminase activity, and obesity. In the whole group the mean serum urate concentration correlated highly significantly with alcohol intake and activities of serum aspartate and alanine transferases but not with ponderal index, serum creatinine concentration, age, or blood pressure. Hypertension and hyperuricaemia are related at least in part through their common association with frequent alcohol use. A serum urate concentration exceeding 0.5 mmol/l (8--4 mg/100 ml) in a man with untreated hypertension is highly suggestive of heavy alcohol consumption. There was no evidence that hyperuricaemia had a deleterious effect on renal function.
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PMID:Hyperuricaemia in hypertension: role of alcohol. 43 9

In order to verify the influence of sampling time on blood constituents, populations of supposedly healthy subjects were grouped according to age, sex, deviation from their ideal weight, state of fasting or nonfasting, and time of sampling. Each fasting subject in one group underwent two samplings during the course of a morning: the first at 08.00 and the second between 09.00 and 12.00. In the second group, the first was taken at 13.00, and the second between 14.00 and 16.00. Subjects in the second group had eaten a standard meal of 700 calories at 12.00. Differences between the paired samples from a given individual are discussed with respect to the time of sampling for plasma urea, creatinine, proteins, albumin, calcium, sodium, potassium, cholesterol, uric acid, chloride ions, phosphate, bilirubin, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, creatine phosphokinase, alkaline phosphatase, hemoglobin and erythrocyte and leukocyte counts. Variations due to the time of sampling were large for phosphorus, bilirubin, and leukocyte count.
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PMID:The effect of sex, deviation from ideal weight and sampling time on blood constituents in presumably healthy subjects. 43 75

Changes in concentration of a number of blood metabolites in 30 thoroughbred horses were recorded after an 1110 metre race. No significant changes occurred in blood urea or aspartate aminotransferase during the three hours after racing. Plasma sodium, potassium and calcium levels were increased immediately after racing but had returned to normal one hour after racing. Plasma phosphate showed a significant fall in concentration one hour after racing. Creatinine and lactic acid concentrations were elevated ten minutes after racing and although they subsequently decreased, the level of lactic acid was still significant one hour later. Uric acid levels were well above resting levels at ten minutes after racing but rose even more in the subsequent hour. Urinary uric acid levels were also elevated during this time. Three hours after racing some horses still had elevated plasma uric acid levels and all of them showed a significant rise in creatine phosphokinase. The possible physiological basis of these findings is discussed.
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PMID:Changes of blood metabolites in horses after racing, with particular reference to uric acid. 44 60

The effect of danazol in a dose of 600 mg a day was studied in 20 women with moderate or severe endometriosis. The clinical effect was found to be excellent and repeat laparoscopy after about 6 months treatment revealed a marked regression in all patients with only small residual foci of endometriosis in two of them. The side effects were few. The metabolic studies revealed a significant increase in serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), serum potassium, serum albumin and serum creatinine, but a significant decrease in serum gamma glutamyl transpeptidase (GT). Serum sodium showed no alteration. A longitudinal study of basal plasma luteinizing hormone (LH) and follicle-stimulating hormone (FSH) and their responses to 25 microgram gonadotrophic releasing hormone (GnRH) i.v. as well as basal plasma levels of oestradiol, oestrone, progesterone and prolactin was performed. During treatment with danazol (600 mg a day) basal levels of LH, FSH, oestradiol, oestrone and progesterone were low but did not differ from the levels found in the early follicular phase of the menstrual cycle. On the other hand the pituitary response to GnRH was significantly greater for both LH and FSH than observed during the early follicular phase. These conflicting results are discussed. It seems that danazol inhibits the pituitary secretion of biologically active LH and FSH and this action is responsible for the decreased ovarian steroid secretion. Whether the atrophy of the uterine and ectopic endometrium is an effect of the reduced oestradiol levels or is a direct effect of danazol on endometrial oestrogen receptors, or a combination of both modes of action, is not clear.
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PMID:Hormonal, metabolic and clinical effects of danazol in the treatment of endometriosis. 53 48

The expert group "Drug Interference in Clinical Chemistry" of the Bureau of Reference, Directorate General for Research, Science and Education of the Commission of the European Communities, consisting of one participant of each member of the European Communities, presents this first report on the final results of its activities. Within the framework of a first stage basic program, the paper describes interferences of therapeutic and elevated doses of ascorbic acid on commonly used clinical chemical methods. This is the result of a bipartite study that was jointly planned, carried out and evaluated. Local and personal influences have been eliminated, as have variations due to methodology, measurement equipment and reagents, in order to be able to present distinct causal effects of ascorbic acid. No definite influence of ascorbic acid on analytical values for urea, cholesterol, calcium, protein, bilirubin, aspartate aminotransferase and alkaline phosphatase could be detected. At therapeutic concentrations, ascorbic acid distinctly interferes with the analysis of glucose, uric acid, creatinine and inorganic phosphate. The extent and direction of interferences vary, depending on the type of reaction, kit and apparatus. In some cases the influence of ascorbic acid results in severe disturbance of the analytical methods leading to useless values.
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PMID:Drug interference in clinical chemistry: studies on ascorbic acid. 62 9

The results of sending specimens through a computerized pneumatic airtransport system and manually delivering specimens were compared for 15 chemical tests and six hematologic procedures. All specimens were collected from inpatients and outpatients into evacuated glass containers. The specimens traversed a maximum of 829 feet (253 meters) involving 16 bends and eight transfer units at 25 feet/second (7.6 meters/second). Only the activity of lactate dehydrogenase exceeded the precision of the test in pneumatically transported specimens. Ruptured erythrocytes in incompletely filled vacuum tubes were the likely source of the increased lactate dehydrogenase activity. Neither the serum sodium, potassium, chloride, carbon dioxide, total protein, albumin, calcium, glucose, creatinine, total bilirubin, alkaline phosphatase, aspartate transaminase, acid phosphatase, uric acid, leukocyte count, erythrocyte count, hemoglobin, hematocrit, nor the prothrombin time and partial thromboplastin time were affected by pneumatic transport. It is concluded that the pneumatic system tested provides a safe, efficient method of transporting the blood specimens tested.
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PMID:Evaluation of a computer-directed pneumatic-tube system for pneumatic transport of blood specimens. 70 6

The inter-relationships of 25 variables in 140 rheumatoid patients were studied. One group, consisting mainly of hematologic variables, was differentiated on the basis of its high correlation with disease activity. The second group consisted of CRP and rheumatoid factor, which had highly significant positive correlations with each other. The third group consisted of serum aspartate aminotransferase, serum creatinine, antistreptolysin titre and blood eosinophils. These relationships are discussed.
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PMID:Inter-relationships of laboratory variables in rheumatoid arthritis. 74 50

Six Caucasion male MIT students, age 19 to 23 years, were given a formula diet providing 0.59 g egg protein/kg body weight/day and energy intakes approximately 10% above their usual requirements. Four subjects continued on this diet for 81 to 89 days, but for the two the protein intake was increased after 50 and 59 days because of an excessive rise in serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. The elevated serum AST and ALT activities fell to normal rapidly when these subjects received a diet providing 1.5 g protein/kg/day from skim milk powder. Body weight increased in five of the subjects. Four showed cumulative negative N balances, and all showed a net loss of total body 40K, which was significant in three. These findings indicate that the 1973 FAO/WHO "safe level" of egg protein intake of 0.57 g/kg is not sufficient for long-term maintenance of most healthy young men. Moreover, the greater N losses calculated from 40K and creatinine measurements than from the N balance data suggest an integumental N loww approximating 15 mg/kg rather than the 5 mg of the 1973 allowances.
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PMID:Human protein requirements: a long-term metabolic nitrogen balance study in young men to evaulate the 1973 FAO/WHO safe level of egg protein intake. 83 93

The values of a number of biochemical variables have been studied before and after a 50-gram load of glucose orally. Reductions which were statistically significant were found for sodium, potassium, urea, total protein, albumin, calcium, phosphorus, urate, bilirubin, alkaline phosphatase, but not for bicarbonate, creatinine, creatine kinase, lactate dehydrogenase, aspartate aminotransferase, cholesterol, triglyceride or chloride. The magnitude of the changes was generally not great, but could be clinically appreciable. The differences may need to be taken into account in comparing population studies.
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PMID:The effect of 50 grams of glucose orally on a number of biochemical variables. 85 60


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