Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P17174 (
aspartate aminotransferase
)
14,872
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
An emerging method to help elucidate the mode of action of experimental drugs is to use untargeted metabolomics of cell-systems. The interpretations of such screens are however complex and more examples with inhibitors of known targets are needed. Here two T-cell lines were treated with an inhibitor of
aspartate aminotransferase
and analyzed with untargeted GC-MS. The interpretation of the data was enhanced by the use of two different cell-lines and supports
aspartate aminotransferase
as a target. In addition, the data suggest an unexpected off-target effect on
glutamate decarboxylase
. The results exemplify the potency of metabolomics to provide insight into both mode of action and off-target effects of drug candidates.
...
PMID:Metabolic effects of an aspartate aminotransferase-inhibitor on two T-cell lines. 3053 26
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