Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P17174 (aspartate aminotransferase)
 14,872 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ninety-nine Black females receiving radium therapy for carcinoma of the cervix uteri under either halothane (50 patients) or enflurane (49 patients) anaesthesia were studied. Thirty-six received a second and 13 a third exposure to halothane or enflurane. There were no significant changes from the control values in the serum concentrations of aspartate aminotransferase (s.g.o.t.), gamma glutamyl transpeptidase (gammaGT), lactic dehydrogenase (SLD), alkaline phosphatase (SAP) and proteins. Total serum bilirubin (TSB) decreased significantly during the first exposure to enflurane (P less than 0.01). This trend was reversed with subsequent anaesthetics in both the halothane and enflurane groups.
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PMID:A prospective study of hepatocellular function after repeated exposures to halothane or enflurane in women undergoing radium therapy for cervical cancer. 92 68

Cervical carcinoma is the second most common cancer worldwide. The extent of free radical induced oxidative stress can be exacerbated by the decreased efficiency of antioxidant defense mechanisms. Low levels of essential antioxidants in the circulation have been found to be associated with an increased risk of cancer. The aim of our study was to assess the extent of oxidative stress, the levels of antioxidants like superoxide dismutase (SOD), catalase (CAT), ceruloplasmin and to evaluate tumor markers such as aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and total sialic acid (TSA) levels in circulation of women with cervical carcinoma and to compare our findings with age matched controls. Low levels of SOD and CAT observed in the circulation of cervical cancer patients may be due to their increased utilization to scavenge lipid peroxides as well as sequestration by tumor cells. Higher levels of TSA, AST, ALT and ALP, in the circulation of cervical cancer patients may be used in the diagnosis and treatment monitoring of patients with cervical carcinoma.
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PMID:Oxidative stress and tumor markers in cervical cancer patients. 1497 92