Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P17174 (
aspartate aminotransferase
)
14,872
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The etiopathogenesis of primary sclerosing cholangitis is unknown. Genetic variants of
fucosyltransferase 2
(
FUT2
) have been identified in genome-wide association studies as risk factors for primary sclerosing cholangitis. We investigated the role of Fut2 in murine liver pathophysiology by studying Fut2
-/-
mice. Fut2
-/-
mice were viable and fertile, had lower body weight than wild-type (wt) littermates and gray fur. Half of the Fut2
-/-
mice showed serum bile salt levels 40 times higher than wt (Fut2
-/-
high
), whereas the remainder were normocholanemic (Fut2
-/-
low
). Fut2
-/-
mice showed normal serum liver tests, bile flow, biliary bile salt secretion, fecal bile salt loss, and expression of major hepatocellular bile salt transporters and cytochrome P450 7a1, the key regulator of bile salt synthesis, indicating that elevated serum bile salts in Fut2
-/-
high
mice were not explained by cholestasis. Fut2
-/-
high
mice, but not Fut2
-/-
low
mice, were sensitive to hydrophobic bile salt feeding (0.3% glycochenodeoxycholate); they rapidly lost weight and showed elevation of serum liver tests (alkaline phosphatase,
aspartate aminotransferase
, alanine aminotransferase) and areas of liver parenchymal necrosis. Histomorphological evaluation revealed the presence of paraportal shunting vessels, increased numbers of portal vascular structures, wall thickening of some portal arteries, and periductal fibrosis in Fut2
-/-
high
mice more than Fut2
-/-
low
mice and not wt mice. Unconjugated bilirubin and ammonia were or tended to be elevated in Fut2
-/-
high
mice only. Portosystemic shunting was demonstrated by portal angiography, which disclosed virtually complete portosystemic shunting in Fut2
-/-
high
mice, discrete portosystemic shunting in Fut2
-/-
low
mice, and no shunting in wt littermates.
...
PMID:Knockout of the primary sclerosing cholangitis-risk gene Fut2 causes liver disease in mice. 2805 90
