Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P17174 (aspartate aminotransferase)
 14,872 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sperm motility, acrosome morphology, changes determined by the vital-lethal test and aspartate aminotransferase (AST) concentration in semen plasma were evaluated in the semen of four boars; the semen was stored for six years. No statistically significant changes in the percentage of motile spermatozoa were indicated when sperm motility was evaluated after four and six years of semen storage in liquid nitrogen. Neither did the fluctuation of the changes found on the basis of the vital-lethal test go beyond statistically insignificant values. After semen sample thawing in the BTS medium, the motility of spermatozoa was found to be somewhat higher than after thawing in the INRA-ITP medium, but after the termination of the thermoresistance test both media appeared to be equally effective. The AST level of the semen samples stored for four years was just slightly up on the initial values. After thawing in the BTS medium, AST level increased by 0.03 microcatal per litre of semen plasma, and in the INTRA-ITP medium by 0.06 microcatal per litre of semen plasma. The insemination of five sows with the semen stored for six years results in conception of two sows, i. e. 40%, and the average litter size was 7.5 piglets. It can be derived from the results that six years of boar semen storage in liquid nitrogen cause no further substantial changes in the structural and functional characteristics of spermatozoa.
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PMID:[Qualitative changes and the fertilizing capacity of sperm after 6 years of preservation of boar semen]. 392 54

We report a case of primary biliary cirrhosis (PBC)-autoimmune hepatitis (AIH) overlap syndrome with concurrent idiopathic thrombocytopenic purpura (ITP) and Hashimoto's disease with positivity for anticentromere antibody. The patient was a 64-year-old woman with symptoms of jaundice and general fatigue. About 30 years earlier, she had been diagnosed as having ITP and had undergone splenectomy. As part of her present history, she had exhibited liver dysfunction in 1995, during the follow-up of Hashimoto's disease, and a liver biopsy led to the diagnosis of PBC. In March 2000, she was admitted to hospital because of general fatigue and jaundice. Blood tests revealed: total protein (TP), 6.6 g/dl; gamma-globulin (glb), 35.9%; total bilirubin (T-bil), 9.41 mg/dl; direct bilirubin (D-bil), 7.52 mg/dl; aspartate aminotransferase (AST), 957 U/l; alanine aminotransferase (ALT), 651 U/l; alkaline phosphatase (ALP), 595 U/l; gamma-guanosine triphosphate (GTP), 129 U/l; IgG, 2620 mg/dl; IgM, 223 mg/dl; hepatitis B surface antigen (HBsAg), negative; anti-hepatitis C virus (HCV), negative; antinuclear antibody, positive; antimitchondrial antibody (AMA), negative (by the immunofluorescence [IF] method); and anti-pyruvate dehydrogenase complex (PDC)-E2 antibody, positive (by Western blotting). Anticentromere antibody (ACA), which is an alternative diagnostic marker for PBC, was detected in this patient. Prednisolone was administered after admission and liver function test results improved markedly. The liver biopsy in 1995 had revealed infiltration of lymphocytes and plasma cells in the portal areas with fibrous expansion and periportal necrosis. Destructive cholangitis was observed, as well as scattered epitheloid cell granulomas in some portal areas. Liver biopsy after the steroid treatment revealed alleviated necrotic inflammatory responses of hepatocytes, while the destructive cholangitis persisted. This is a very rare case of PBC-AIH overlap syndrome accompanied by ITP and Hashimoto's disease which provides a possible insight into the mechanisms and interplay of autoimmune diseases.
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PMID:PBC-AIH overlap syndrome with concomitant ITP and Hashimoto's disease with positivity for anti-centromere antibody. 1517 50