Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P17174 (aspartate aminotransferase)
 14,872 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The paper presents the results of a combined biochemical study of 111 patients suffering from recently diagnosed pulmonary tuberculosis combined with chronic opisthorchiasis (main group) and 36 tuberculosis patients without infestation (control group). It was established that the mixed abnormality was significantly more often accompanied by hypoproteinemia and hypoalbuminemia. The thymol and mercury-chloride sublimate tests produced positive results in 22.5 and 9.0% of the main group patients, respectively. Increased bilirubin content and alanine and aspartate aminotransferase activities were registered in both groups of patients only during medical treatment. Thus, the fact of altered protein forming function of liver in patients with tuberculosis combined with chronic opisthorchiasis has been established, which may be due both to tuberculosis infection and the Opisthorchis invasion. Insignificant hepatic protein-forming dysfunctions are not contraindications for long-term tuberculosis therapy.
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PMID:[Biochemical indices of the blood in patients with tuberculosis combined with chronic opisthorchiasis]. 261 4

The main biochemical indices of hepatic functions (the activities of alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, alkaline phosphatase, alpha-amylase, choline esterase and the concentrations of total bilirubin, cholesterol, and glucose) were studied in the sera of 256 patients with chronic opisthorchiasis. It was found that with diseases manifested in different clinical forms (cholangitis, cholecystitis, cholangiocholecystitis, cholangiohepatitis, cholecystitis in combination with pancreatitis), most study indices are within the normal ranges, but significantly differ from the means in a group of apparently healthy individuals. The findings suggest that such clinical forms of opisthorchiais as cholangiocholecystitis and cholangiohepatitis are characterized by manifestations of cytolysis and cholestasis, as cholecystitis is manifested by cytolysis, as cholecystitis in combination with pancreatitis, by cholestasis, and as cholangitis, by cholestasis and hepatic cell insufficiency. It is possible that further studies will provide evidence for how to correct detected disorders during pathogenetic therapy.
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PMID:[Biochemical characteristics of hepatic functions in different clinical forms of chronic opisthorchiasis]. 1222 56

A complex of biochemical parameters of hepatic functions was analyzed in 170 patients with chronic opisthorchiasis and in 90 apparently healthy dwellers from a region wherein opisthorchiasis is endemic. The activity of aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transferase, alkaline phosphatase, alpha-amylase, and choline esterase and the serum concentrations of bilirubin, cholesterol, and glucose were studied. A correlation analysis indicated that prolonged Opisthorchis invasion rearranged the system of interactions of the biochemical parameters of the functions of the liver and pancreas. The auxiliary ("local") standards obtained from a study of a group of apparently healthy dwellers from an opisthorchiasis-endemic region may be use to consider the results of individual examinations of patients with chronic opisthorchiasis in order to correct the processes of treatment and rehabilitation.
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PMID:[Analysis of a complex of biochemical parameters of hepatic functions in opisthorchiasis]. 1644 32