Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P16104 (H2AX)
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Human Gene/Protein
C20orf135 13.0
H2AX 13.0
H2BFM 13.0
QSCN6 13.0
phosphoinositide-3-kinase adaptor protein 1 13.0
HIST3H2BB 13.0
zinc finger protein 12 13.0
X-ray radiation resistance associated 1 13.0
Tripartite motif-containing protein 29 13.0
Histone H2A type 1 13.0
Histone H2B type 1-K 13.0
KIAA0638 13.0
MARP3 13.0
nucleolar localized protein 13.0
GLB1L 12.0
KRCC1 12.0
ZNF506 12.0
eyes absent 2 12.0
Zinc finger protein 668 12.0
CCDC84 12.0
RGPD6 12.0
CCDC99 12.0
MDC1 11.6
mitogen-activated protein kinase kinase kinase 9 11.4
testis-specific histone H2B 11.4
tumor suppressor p53-binding protein 1 11.4
FIGNL1 11.4
EBNA1BP2 11.4
histone H2A.2 11.4
RAD52 motif 1 11.4
galactosidase, beta 1 11.4
C13orf34 11.4
H2A histone family member 11.4
NFBD1 11.4
KIAA0170 11.2
p53 binding protein 11.1
Eyes absent 2 11.0
Mediator of DNA damage checkpoint 1 11.0
Kinase-related protein 11.0
TMEM24 11.0
zinc finger and SCAN domain containing 21 11.0
LL5A 11.0
PP6R3 11.0
sulfotransferase 1C2 11.0
MAP17 protein 11.0
Histone H1.2 11.0
53BP1 10.9
SPSB3 10.7
nuclear receptor binding protein 2 10.7
DNAJC1 10.7
MIZF 10.7
ATP6V1D 10.7
PRTFDC1 10.7
NRBP2 10.7
zinc finger protein 2 10.7
ATLD 10.7
BRCA2 and CDKN1A interacting protein 10.7
PP6R2 10.4
macroH2A2 10.4
PPP4R2 10.4
ARP8 10.4
Hipk1 10.4
histone H2A.1 10.4
RPA32 10.4
CHK2 10.4
RNF8 10.4
CCDC98 10.2
Werner syndrome helicase 10.2
RNF168 10.2
Rev7p 10.2
PLRG1 10.2
PCID2 10.2
recombination repair protein 10.2
TEX15 10.2
Tousled-like kinase 1 10.2
ATR interacting protein 10.2
HIST1H2AL 10.2
PP6R1 10.2
BRIT1 10.1
ataxia telangiectasia mutated 10.1
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Disease
RS-SCID 9.2
oral neoplasm 9.0
ATM 8.8
Mammary adenocarcinoma 8.7
MYP3 8.6
MCPH1 8.5
Senile osteoporosis 8.5
WT3 8.3
neck neoplasm 8.1
FHA 8.0
SCAN1 7.9
FANCN 7.9
FANCJ 7.8
La Crosse encephalitis 7.8
Mandibuloacral dysplasia 7.7
DMAT 7.6
recurrent SCLC 7.5
FA2 7.4
Seckel syndrome 7.2
FANCD1 7.2
XP-A 7.1
glue sniffing 7.1
FANCI 7.0
XPE 7.0
Precancerous lesions 7.0
radiation carcinogenesis 7.0
Cerebellar atrophy 6.9
XPF 6.9
roseola 6.8
testicular embryonal carcinoma 6.7
SCA17 6.7
BMH 6.7
PSN 6.7
ABC-DLBCL 6.6
environmental carcinogenesis 6.6
XPD 6.6
NBS 6.5
Mucolipidosis type IV 6.5
HP1 6.4
Taybi 6.4
Dental fluorosis 6.2
XPB 6.2
PBD 6.2
endocrine cancer 6.2
premature aging 6.1
trisomy 15 6.1
WRN 6.0
optic nerve glioma 6.0
CSB 6.0
CSB 5.9
progeria 5.9
relapsed CLL 5.9
metastatic cervical cancer 5.9
CREST 5.8
Fanconi 5.8
Silence 5.8
carcinoma of the tongue 5.6
Fibrosarcoma 5.6
BLM 5.5
Postoperative cognitive dysfunction 5.5
trichothiodystrophy 5.5
Testicular torsion 5.4
LCS 5.4
Cockayne syndrome 5.4
Chemoradiation 5.4
Middle cerebral artery occlusion 5.3
CDT 5.3
ATRX 5.2
Selenium deficiency 5.2
testicular atrophy 5.2
xeroderma pigmentosum 5.2
FRAXA 5.2
XPG 5.1
Shigella boydii 5.1
malignant meningioma 5.1
HNSCC 5.1
Spitz nevus 5.1
vaginal cancer 5.0
PML 4.9
MIN 4.9
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Symptom
Halo 4.1
skin damage 4.0
CSR 3.5
collapse 2.6
hyperoxia 2.6
ataxia 2.5
cerebellar ataxia 2.2
bradykinesia 1.8
exhaustion 1.6
starvation 0.7
hypothermia 0.5
overweight -0.1
respiratory distress -0.3
splenomegaly -0.3
thinning -0.5
diarrhea -0.5
erythema -0.7
anorexia -0.8
acidity -0.9
seizures -1.3
discomfort -1.5
nausea -1.5
cough -1.6
discomfort -1.6
vomiting -2.0
fatigue -2.7
pain -3.4
anesthesia -3.8
Drug
Irofulven 9.0
Tricyclazole 8.3
Adozelesin 8.2
Trabectedin 7.4
Epalrestat 7.4
Vorinostat 7.3
Crotonaldehyde 7.3
Sodium ascorbate 7.2
Tipifarnib 6.9
Ciglitazone 6.7
Truvada 6.6
Tolfenamic acid 6.6
7-Nitroindazole 6.5
Tirapazamine 6.5
Mizoribine 6.4
Etoposide 6.3
Mutagen 6.3
Neocarzinostatin 6.2
BLM 6.2
Sesamol 6.1
TFT 6.0
Hyperforin 5.9
Cidofovir 5.9
Areca 5.9
Saha 5.9
Clofarabine 5.9
Oxaliplatin 5.7
Myricetin 5.7
PFT 5.6
Panitumumab 5.6
Podophyllum 5.6
2-Methoxyestradiol 5.6
Dexrazoxane 5.6
Artesunate 5.6
Truvada 5.5
Gatifloxacin 5.5
Gemzar 5.4
ROS 5.4
Mitomycin-C 5.3
Tolvaptan 5.2
Entecavir 5.2
Entecavir 5.2
Cytidine 5.1
Ammonium chloride 5.1
Arsenic trioxide 5.0
Propidium 5.0
Dihydro 5.0
Levovist 4.9
Silica gel 4.8
Bortezomib 4.8
Taxotere 4.7
Erlotinib 4.4
CPT-11 4.4
Rosiglitazone 4.3
Irinotecan 4.3
Aminoguanidine 4.3
Emodin 4.1
Cetuximab 4.1
NVP 4.1
caffeine 4.0
balanced salt solution 4.0
Troglitazone 3.9
Emodin 3.8
Dasatinib 3.7
TTC 3.7
VCR 3.7
Kainic acid 3.6
ZnCl2 3.6
ZnCl2 3.6
ETS 3.6
Lovastatin 3.6
MRC 3.6
ADR 3.6
-deoxyadenosine 3.5
Everolimus 3.5
Sorafenib 3.4
Herceptin 3.4
Adriamycin 3.4
GEO 3.4
Zoledronic acid 3.3
more...
Enzyme
CYP39A1 8.8
PARP 7.2
RNase D 6.9
10-formyltetrahydrofolate dehydrogenase 6.9
CSAD 6.7
topoisomerase 6.4
topoisomerase 6.4
caspase-2 6.4
caspase-2 6.3
CYP7B1 6.0
nicotinamide mononucleotide adenylyltransferase 6.0
endodeoxyribonuclease 5.9
deoxyguanosine kinase 5.8
caspase-7 5.8
arachidonate 5-lipoxygenase 5.8
caspase-7 5.7
histone acetyltransferase 5.6
caspase-3 5.6
caspase-4 5.5
carboxypeptidase G2 5.5
valyl-tRNA synthetase 5.4
caspase-4 5.3
poly(ADP-ribose) glycohydrolase 5.3
endonuclease VII 5.3
DNA ligase 5.3
DNA ligase 5.3
phosphatidylethanolamine N-methyltransferase 5.2
glutathione synthetase 5.2
methylthioadenosine phosphorylase 5.1
STK11 5.1
guanase 5.1
caspase-8 5.1
GAR 5.0
cytosine deaminase 5.0
CEP 5.0
O-GlcNAc transferase 5.0
dihydroorotate dehydrogenase 5.0
protein phosphatase 2A 5.0
dihydroorotate dehydrogenase 5.0
polo-like kinase 1 5.0
cdc2 5.0
ubiquitin-protein ligase 4.9
caspase-9 4.9
pyruvate oxidase 4.9
pyruvate oxidase 4.9
isopeptidase 4.8
ribonucleotide reductase 4.8
PHD 4.8
ALDH 4.8
ribonucleotide reductase 4.8
Fpg protein 4.6
Lys4 4.5
deoxycytidine kinase 4.5
CEP 4.5
DNA methyltransferase 4.4
DCF 4.4
biotinidase 4.4
3'-exonuclease 4.3
HCS 4.3
hypoxanthine-guanine phosphoribosyltransferase 4.3
endonuclease 4.3
histone demethylase 4.1
caspase-6 4.1
phosphoinositide 3-kinase 4.1
cytidine deaminase 4.0
thioredoxin reductase 4.0
cathepsin S 4.0
caspase-6 4.0
asparagine synthetase 4.0
angiotensin-converting enzyme 2 4.0
NQO1 4.0
farnesyltransferase 4.0
HK2 3.9
micrococcal nuclease 3.8
prenyltransferase 3.8
calcineurin 3.8
CDH 3.8
1-hydroxylase 3.8
serine hydroxymethyltransferase 3.8
MTD 3.8
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Compound
2-(4-chlorophenyl)benzo-1,4-quinone 12.4
Avenanthramide A 12.0
Eurycomalactone 11.4
Ara-HA 11.0
2'-Hydroxychalcone 11.0
Tebufenpyrad 9.8
Resmethrin 9.5
Quinalizarin 9.5
Microcephalin 9.5
Hedamycin 9.4
Aeroplysinin-1 9.2
Myosmine 9.1
Ovatodiolide 9.1
2,4-DMA 9.0
Butylidenephthalide 8.5
Angelicin 8.5
Saikosaponin A 8.5
Phosphoramide mustard 8.4
Myristicin 8.3
Rafoxanide 8.3
Solanine 8.3
MINA 8.2
Lanatoside C 8.2
Solanine 8.1
1H-benzo[de]isoquinoline-1,3(2H)-dione 8.1
Chloranil 8.0
Plastoquinone 7.9
MTIC 7.9
Fostriecin 7.8
Amentoflavone 7.6
4-methoxybenzaldehyde 7.6
4-methoxybenzaldehyde 7.6
Nitidine 7.6
4-methoxybenzaldehyde 7.5
4-methoxybenzaldehyde 7.5
4-methoxybenzaldehyde 7.5
4-methoxybenzaldehyde 7.5
beta-Lapachone 7.5
7H-dibenzo[c,g]carbazole 7.4
4-methoxybenzaldehyde 7.4
Diepoxybutane 7.4
1,2,4-benzotriazine 7.4
G 1 7.4
hydroxymethylbilane 7.3
4-methoxybenzaldehyde 7.3
Methyleugenol 7.3
4-methoxybenzaldehyde 7.3
Histone 7.2
Phenanthrenequinone 7.2
Anacardic acid 7.2
Juglone 7.1
Potassium bromate 7.0
Carnosol 7.0
10-Hydroxycamptothecin 7.0
Dihydromyricetin 6.9
8-hydroxyguanosine 6.9
HN2 6.9
XPA 6.9
1,2-dichloropropane 6.9
XPA 6.9
Nedaplatin 6.8
Camptothecin 6.8
Camptothecin 6.8
Camptothecin 6.8
Bufalin 6.7
hydrazinecarbothioamide 6.6
2-methylquinoline 6.6
Methacrylic acid 6.6
Azoxymethane 6.6
GRG 6.5
Propylparaben 6.5
Cepharanthine 6.5
Trifluorothymidine 6.5
2-methylquinoline 6.4
methyl methanesulfonate 6.4
DMAE 6.4
8-OHdG 6.4
Hyperoside 6.3
IBT 6.3
Neocarzinostatin 6.2
more...