Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: UNIPROT:P16104 (H2AX)
3,930 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein H2AX 3930 histone 1173 p53 711 ATM 606 Mol 448 53BP1 322 ATR 284 caspase-3 275 Chk1 262 DNA-dependent protein kinase 262 Sep 245 p21 233 PARP 209 BRCA1 209 Chk2 179 ataxia telangiectasia mutated 143 Rad51 134 RAD51 130 A-T 126 MDC1 123 ROS 99 Bcl-2 93 histone H2A 92 NBS1 88 histone H3 85 H2A 77 CHK2 74 Ku70 72 p38 68 PARP-1 68 CHK1 66 histone deacetylase 63 ubiquitin 62 poly(ADP-ribose) polymerase 60 phosphatase 59 ATP 58 telomeric 58 proliferating cell nuclear antigen 58 Rad50 57 MRE11 57 topoisomerase I 55 JNK 55 annexin V 55 Ku80 53 p16 46 AKT 46 PI3K 45 TNF 45 endonuclease 44 BRCA2 43 ERK 42 ADP 42 catalase 41 PARP1 40 caspase-9 39 RNF8 39 H2A.X 38 mTOR 38 caspase-8 38 proteasome 37 RAD50 36 RPA 36 superoxide dismutase 36 helicase 35 MAPK 35 histone protein 34 IL-6 34 threonine 33 cyclin D1 32 cytochrome c 32 FANCD2 30 survivin 29 osteosarcoma 29 cyclin B1 29 ERK1 28 phosphorylating 27 p53 binding protein 27 PUMA 26 RNF168 26 BAX 26 more...

Disease cancer 1156 ATM 706 tumor 634 breast cancer 201 carcinogenesis 130 tumorigenesis 108 carcinoma 104 tumor growth 102 lung cancer 92 leukemia 88 MCF 71 prostate cancer 69 glioblastoma 64 adenocarcinoma 63 colorectal cancer 62 glioma 59 colon cancer 58 hepatocellular carcinoma 58 non-small cell lung cancer 48 melanoma 48 ovarian cancer 47 tumor progression 44 lymphoma 40 cervical cancer 37 acute myeloid leukemia 34 squamous cell carcinoma 33 pancreatic cancer 32 anemia 30 osteosarcoma 30 Fanconi 28 neuroblastoma 23 GSH 23 SCID 22 glioblastoma multiforme 22 ischemia 22 B-cell lymphoma 21 lung carcinoma 21 NBS 21 retinoblastoma 21 multiple myeloma 19 immunodeficiency 19 premature aging 19 gastric cancer 19 chronic lymphocytic leukemia 19 sarcoma 18 WRN 17 liver cancer 17 BLM 17 chronic lymphocytic leukemia 17 neoplastic transformation 16 PML 16 bladder cancer 16 FHA 16 skin cancer 14 genetic disorder 14 esophageal cancer 14 esophageal cancer 14 xeroderma pigmentosum 13 Leukemia 13 diabetes 12 acute promyelocytic leukemia 12 HIV 12 Blocking 12 chronic myeloid leukemia 12 infertility 11 acute lymphoblastic leukemia 11 renal cell carcinoma 11 Alzheimer's disease 10 metastases 10 myelodysplastic syndrome 10 Epstein 10 XPD 10 HCC 10 HP1 10 Melanoma 9 Barrett's esophagus 9 Huntington's disease 9 fibrosarcoma 9 epithelial ovarian cancer 9 hematologic malignancies 9 more...

Symptom collapse 22 ataxia 11 starvation 5 diarrhea 5 exhaustion 5 seizures 4 hyperoxia 4 overweight 3 hypothermia 3 pain 3 skin damage 3 respiratory distress 2 cerebellar ataxia 2 cough 1 discomfort 1 nausea 1 anesthesia 1 Halo 1 anorexia 1 bradykinesia 1 thinning 1 discomfort 1 acidity 1 splenomegaly 1 erythema 1 vomiting 1 CSR 1 fatigue 1

Drug ROS 99 lysine 69 Mutagen 57 caffeine 43 BLM 12 ascorbate 12 Etoposide 11 Dermatol 9 DNase I 8 Vorinostat 7 Adriamycin 6 Oxaliplatin 6 Monit 6 ZnO 6 Arsenic trioxide 5 Glutathione 5 MAP 5 CPT-11 5 Indomethacin 5 Bortezomib 5 MRC 5 ETS 4 NADH 3 -deoxyadenosine 3 TiO2 3 PFT 3 HCH 3 CSF 3 TTC 3 Gel 3 ADR 3 Trabectedin 3 Herceptin 3 CTX 3 vitamin E 3 balanced salt solution 3 NVP 2 TFT 2 Docetaxel 2 Cetuximab 2 Erlotinib 2 Myricetin 2 Areca 2 Imatinib 2 Irinotecan 2 G-CSF 2 Lovastatin 2 Nitric Oxide 2 ENT 2 AZT 2 Vitamin E 2 Rosiglitazone 2 GEO 2 AZT 2 MOF 2 Irofulven 2 Leaf 2 Taxotere 2 ampicillin 2 Artesunate 2 Check 2 ZnCl2 2 Sorafenib 2 Dihydro 2 Cidofovir 2 ZnCl2 2 G418 2 Albumin 2 Troglitazone 1 7-Nitroindazole 1 Taxol 1 TAT 1 CAM 1 Kainic acid 1 Silica gel 1 Gatifloxacin 1 Silica 1 EPA 1 Entecavir 1 VCR 1 more...

Enzyme PARP 255 caspase-3 208 mitogen-activated protein kinase 117 protein kinase 112 topoisomerase 103 topoisomerase 96 ERK 84 superoxide dismutase 53 catalase 45 endonuclease 44 proteasome 37 cdc2 32 calcineurin 30 caspase-8 29 caspase-9 28 DNA polymerase 25 ATPase 22 luciferase 21 focal adhesion kinase 20 RNA polymerase 18 MEK 18 histone acetyltransferase 16 beta-galactosidase 16 phosphatidylinositol 3-kinase 13 DNA ligase 13 DNA methyltransferase 13 DNA ligase 13 phosphoinositide 3-kinase 12 protein phosphatase 2A 12 NQO1 12 AMP-activated protein kinase 12 lactate dehydrogenase 12 glutathione peroxidase 11 ribonucleotide reductase 10 ribonucleotide reductase 10 AMPK 8 protein kinase C 8 AMPK 8 caspase-2 8 caspase-2 8 glutathione S-transferase 7 GSK 7 peroxidase 6 polo-like kinase 1 6 RNase 6 thymidylate synthase 6 DNase 6 ACS 6 caspase-7 6 alanine aminotransferase 6 caspase-7 6 hypoxanthine-guanine phosphoribosyltransferase 6 APC 6 NADPH oxidase 5 micrococcal nuclease 5 DCF 5 collagenase 5 phosphodiesterase 5 thioredoxin reductase 5 MAP 5 succinate dehydrogenase 5 reverse transcriptase 4 complex I 4 NADPH oxidase 4 cathepsin B 4 aspartate aminotransferase 4 RNase 4 thymidine kinase 4 demethylase 4 glutathione reductase 4 glyceraldehyde-3-phosphate dehydrogenase 3 transcriptase 3 PHD 3 heme oxygenase 3 P-glycoprotein 3 glyceraldehyde-3-phosphate dehydrogenase 3 cytosine deaminase 3 cathepsin D 3 peroxiredoxin 3 alkaline phosphatase 3 more...

Compound DNA 3417 oxygen 355 Dec 265 serine 227 Histone 91 lysine 77 hydrogen 65 cysteine 62 MTT 62 ATP 58 MDA 53 threonine 52 ADP-ribose 51 water 45 TNF 45 ADP 45 N-acetylcysteine 44 caffeine 43 ADP 42 ADP 42 iodine 41 H2O2 40 sodium 33 8-OHdG 33 tyrosine 33 pyrene 32 iron 32 Clin 29 GSH 28 GSH 28 Adriamycin 27 methyl methanesulfonate 25 ADR 24 calcium 23 diacetate 23 nitric oxide 22 NAD 22 dUTP 22 nitrogen 21 NAD 20 phosphate 19 Serine 16 bromide 16 XPA 15 PAR 15 alanine 15 pyrimidine 15 DDP 15 BLM 15 XPA 15 VP-16 15 pyrimidine 15 chromium 14 copper 14 arginine 14 glucose 14 acetate 13 hydroquinone 13 MEK 12 Resveratrol 12 boron 12 zinc 12 DMSO 11 ethanol 11 benzene 11 cAMP 10 salt 10 acridine 10 creatinine 9 formaldehyde 9 Curcumin 9 nicotinamide 9 silicon 9 MIA 9 silver 9 Camptothecin 8 urea 8 sulfate 8 anthracene 8 Camptothecin 8 more...

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