Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P16104 (H2AX)
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Human Gene/Protein
C20orf135 13.0
X-ray radiation resistance associated 1 13.0
nucleolar localized protein 13.0
Histone H2B type 1-K 13.0
Histone H2A type 1 13.0
HIST3H2BB 13.0
QSCN6 13.0
phosphoinositide-3-kinase adaptor protein 1 13.0
H2BFM 13.0
Tripartite motif-containing protein 29 13.0
zinc finger protein 12 13.0
MARP3 13.0
H2AX 13.0
KIAA0638 13.0
Zinc finger protein 668 12.0
KRCC1 12.0
GLB1L 12.0
ZNF506 12.0
RGPD6 12.0
eyes absent 2 12.0
CCDC99 12.0
CCDC84 12.0
MDC1 11.6
C13orf34 11.4
mitogen-activated protein kinase kinase kinase 9 11.4
histone H2A.2 11.4
tumor suppressor p53-binding protein 1 11.4
galactosidase, beta 1 11.4
RAD52 motif 1 11.4
testis-specific histone H2B 11.4
EBNA1BP2 11.4
FIGNL1 11.4
H2A histone family member 11.4
NFBD1 11.4
KIAA0170 11.2
p53 binding protein 11.1
LL5A 11.0
TMEM24 11.0
Histone H1.2 11.0
zinc finger and SCAN domain containing 21 11.0
more...
Disease
RS-SCID 9.2
oral neoplasm 9.0
ATM 8.8
Mammary adenocarcinoma 8.7
MYP3 8.6
MCPH1 8.5
Senile osteoporosis 8.5
WT3 8.3
neck neoplasm 8.1
FHA 8.0
SCAN1 7.9
FANCN 7.9
FANCJ 7.8
La Crosse encephalitis 7.8
Mandibuloacral dysplasia 7.7
DMAT 7.6
recurrent SCLC 7.5
FA2 7.4
Seckel syndrome 7.2
FANCD1 7.2
XP-A 7.1
glue sniffing 7.1
FANCI 7.0
Precancerous lesions 7.0
XPE 7.0
radiation carcinogenesis 7.0
Cerebellar atrophy 6.9
XPF 6.9
roseola 6.8
testicular embryonal carcinoma 6.7
BMH 6.7
SCA17 6.7
PSN 6.7
ABC-DLBCL 6.6
environmental carcinogenesis 6.6
XPD 6.6
NBS 6.5
Mucolipidosis type IV 6.5
HP1 6.4
Taybi 6.4
more...
Symptom
Halo 4.1
skin damage 4.0
CSR 3.5
collapse 2.6
hyperoxia 2.6
ataxia 2.5
cerebellar ataxia 2.2
bradykinesia 1.8
exhaustion 1.6
starvation 0.7
hypothermia 0.5
overweight -0.1
respiratory distress -0.3
splenomegaly -0.3
thinning -0.5
diarrhea -0.5
erythema -0.7
anorexia -0.8
acidity -0.9
seizures -1.3
discomfort -1.5
nausea -1.5
cough -1.6
discomfort -1.6
vomiting -2.0
fatigue -2.7
pain -3.4
anesthesia -3.8
Drug
Irofulven 9.0
Tricyclazole 8.3
Adozelesin 8.2
Trabectedin 7.4
Epalrestat 7.4
Vorinostat 7.3
Crotonaldehyde 7.3
Sodium ascorbate 7.2
Tipifarnib 6.9
Ciglitazone 6.7
Tolfenamic acid 6.6
Truvada 6.6
Tirapazamine 6.5
7-Nitroindazole 6.5
Mizoribine 6.4
Etoposide 6.3
Mutagen 6.3
Neocarzinostatin 6.2
BLM 6.2
Sesamol 6.1
TFT 6.0
Hyperforin 5.9
Cidofovir 5.9
Areca 5.9
Saha 5.9
Clofarabine 5.9
Oxaliplatin 5.7
Myricetin 5.7
PFT 5.6
Panitumumab 5.6
Podophyllum 5.6
2-Methoxyestradiol 5.6
Dexrazoxane 5.6
Artesunate 5.6
Truvada 5.5
Gatifloxacin 5.5
Gemzar 5.4
ROS 5.4
Mitomycin-C 5.3
Tolvaptan 5.2
more...
Enzyme
CYP39A1 8.8
PARP 7.2
RNase D 6.9
10-formyltetrahydrofolate dehydrogenase 6.9
CSAD 6.7
topoisomerase 6.4
topoisomerase 6.4
caspase-2 6.4
caspase-2 6.3
CYP7B1 6.0
nicotinamide mononucleotide adenylyltransferase 6.0
endodeoxyribonuclease 5.9
deoxyguanosine kinase 5.8
caspase-7 5.8
arachidonate 5-lipoxygenase 5.8
caspase-7 5.7
histone acetyltransferase 5.6
caspase-3 5.6
caspase-4 5.5
carboxypeptidase G2 5.5
valyl-tRNA synthetase 5.4
caspase-4 5.3
poly(ADP-ribose) glycohydrolase 5.3
endonuclease VII 5.3
DNA ligase 5.3
DNA ligase 5.3
glutathione synthetase 5.2
phosphatidylethanolamine N-methyltransferase 5.2
methylthioadenosine phosphorylase 5.1
STK11 5.1
guanase 5.1
caspase-8 5.1
GAR 5.0
cytosine deaminase 5.0
CEP 5.0
O-GlcNAc transferase 5.0
dihydroorotate dehydrogenase 5.0
protein phosphatase 2A 5.0
dihydroorotate dehydrogenase 5.0
polo-like kinase 1 5.0
more...
Compound
2-(4-chlorophenyl)benzo-1,4-quinone 12.4
Avenanthramide A 12.0
Eurycomalactone 11.4
2'-Hydroxychalcone 11.0
Ara-HA 11.0
Tebufenpyrad 9.8
Resmethrin 9.5
Quinalizarin 9.5
Microcephalin 9.5
Hedamycin 9.4
Aeroplysinin-1 9.2
Ovatodiolide 9.1
Myosmine 9.1
2,4-DMA 9.0
Angelicin 8.5
Butylidenephthalide 8.5
Saikosaponin A 8.5
Phosphoramide mustard 8.4
Myristicin 8.3
Rafoxanide 8.3
Solanine 8.3
MINA 8.2
Lanatoside C 8.2
Solanine 8.1
1H-benzo[de]isoquinoline-1,3(2H)-dione 8.1
Chloranil 8.0
Plastoquinone 7.9
MTIC 7.9
Fostriecin 7.8
Amentoflavone 7.6
4-methoxybenzaldehyde 7.6
Nitidine 7.6
4-methoxybenzaldehyde 7.6
4-methoxybenzaldehyde 7.5
4-methoxybenzaldehyde 7.5
4-methoxybenzaldehyde 7.5
4-methoxybenzaldehyde 7.5
beta-Lapachone 7.5
7H-dibenzo[c,g]carbazole 7.4
4-methoxybenzaldehyde 7.4
more...