Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P16104 (H2AX)
 3,930 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
nucleolar localized protein 13.0
MARP3 13.0
H2AX 13.0
zinc finger protein 12 13.0
Histone H2A type 1 13.0
phosphoinositide-3-kinase adaptor protein 1 13.0
Histone H2B type 1-K 13.0
QSCN6 13.0
C20orf135 13.0
KIAA0638 13.0
H2BFM 13.0
Tripartite motif-containing protein 29 13.0
X-ray radiation resistance associated 1 13.0
HIST3H2BB 13.0
Zinc finger protein 668 12.0
RGPD6 12.0
KRCC1 12.0
eyes absent 2 12.0
CCDC99 12.0
GLB1L 12.0
CCDC84 12.0
ZNF506 12.0
MDC1 11.6
EBNA1BP2 11.4
galactosidase, beta 1 11.4
FIGNL1 11.4
RAD52 motif 1 11.4
histone H2A.2 11.4
tumor suppressor p53-binding protein 1 11.4
C13orf34 11.4
testis-specific histone H2B 11.4
mitogen-activated protein kinase kinase kinase 9 11.4
H2A histone family member 11.4
NFBD1 11.4
KIAA0170 11.2
p53 binding protein 11.1
TMEM24 11.0
LL5A 11.0
zinc finger and SCAN domain containing 21 11.0
MAP17 protein 11.0
PP6R3 11.0
Kinase-related protein 11.0
Mediator of DNA damage checkpoint 1 11.0
Histone H1.2 11.0
sulfotransferase 1C2 11.0
Eyes absent 2 11.0
53BP1 10.9
DNAJC1 10.7
ATP6V1D 10.7
SPSB3 10.7
nuclear receptor binding protein 2 10.7
zinc finger protein 2 10.7
MIZF 10.7
NRBP2 10.7
ATLD 10.7
BRCA2 and CDKN1A interacting protein 10.7
PRTFDC1 10.7
PP6R2 10.4
PPP4R2 10.4
Hipk1 10.4
histone H2A.1 10.4
RPA32 10.4
ARP8 10.4
macroH2A2 10.4
CHK2 10.4
RNF8 10.4
CCDC98 10.2
Werner syndrome helicase 10.2
RNF168 10.2
PP6R1 10.2
HIST1H2AL 10.2
PLRG1 10.2
Tousled-like kinase 1 10.2
Rev7p 10.2
ATR interacting protein 10.2
PCID2 10.2
TEX15 10.2
recombination repair protein 10.2
BRIT1 10.1
ataxia telangiectasia mutated 10.1
DNA topoisomerase 2 10.1
meiotic recombination 11 10.0
Chk2 10.0
POLR2F 10.0
LL5beta 10.0
TMEM79 10.0
DHP1 10.0
RNF26 10.0
PYROXD1 10.0
HIST1H2BK 10.0
BTBD12 10.0
Relaxin 3 10.0
TREH 10.0
STRN3 10.0
H2A.X 9.9
NBS1 9.9
NEK4 9.9
TSKS 9.8
HIST2H2BE 9.8
ALG-4 9.8
FOXN5 9.8
Arp5 9.8
M-LPH 9.8
MEI1 9.8
Histone H2A 9.8
RPA2 9.8
ATM 9.7
BRCC45 9.7
HUS1 9.7
macroH2A1.2 9.7
kinase-related protein 9.7
PDZK2 9.7
cytochrome c, somatic 9.7
TNFAIP8L1 9.7
RAD54B 9.7
OTUB2 9.7
TOPBP1 9.6
CHK1 9.6
SYCP1 9.6
WIP1 9.6
p202 9.6
NADPH oxidase 1 9.6
FANCA protein 9.6
SMC1 9.6
MRE11 9.5
DNA-dependent protein kinase 9.5
RPA4 9.5
DDX18 9.5
TPD52L1 9.5
ubiquitin-specific protease 3 9.5
Microcephalin 9.5
ribonuclease H2 9.5
Monad 9.5
TRAPPC4 9.5
Chk1 9.5
NHEJ1 9.5
CTIP 9.5
PTIP 9.5
H2AZ 9.4
PBL1 9.4
YAF2 9.4
BRCA1-associated RING domain 1 9.4
X-ray repair cross-complementing protein 4 9.4
TSSK6 9.4
ROGDI 9.4
ALKBH8 9.4
PNAS-4 9.4
MADA 9.4
GNAI2 9.4
cell cycle checkpoint protein 9.4
histone H1.2 9.3
USP3 9.3
H2A histone 9.3
histone H2A 9.3
Wip1 9.3
STBP 9.3
DEK gene 9.3
P53-binding protein 9.3
ARCN1 9.3
NUP133 9.3
more...
Disease
RS-SCID 9.2
oral neoplasm 9.0
ATM 8.8
Mammary adenocarcinoma 8.7
MYP3 8.6
MCPH1 8.5
Senile osteoporosis 8.5
WT3 8.3
neck neoplasm 8.1
FHA 8.0
SCAN1 7.9
FANCN 7.9
FANCJ 7.8
La Crosse encephalitis 7.8
Mandibuloacral dysplasia 7.7
DMAT 7.6
recurrent SCLC 7.5
FA2 7.4
Seckel syndrome 7.2
FANCD1 7.2
XP-A 7.1
glue sniffing 7.1
FANCI 7.0
Precancerous lesions 7.0
XPE 7.0
radiation carcinogenesis 7.0
Cerebellar atrophy 6.9
XPF 6.9
roseola 6.8
testicular embryonal carcinoma 6.7
BMH 6.7
SCA17 6.7
PSN 6.7
ABC-DLBCL 6.6
environmental carcinogenesis 6.6
XPD 6.6
NBS 6.5
Mucolipidosis type IV 6.5
HP1 6.4
Taybi 6.4
Dental fluorosis 6.2
XPB 6.2
PBD 6.2
endocrine cancer 6.2
premature aging 6.1
trisomy 15 6.1
WRN 6.0
optic nerve glioma 6.0
CSB 6.0
CSB 5.9
progeria 5.9
relapsed CLL 5.9
metastatic cervical cancer 5.9
CREST 5.8
Fanconi 5.8
Silence 5.8
carcinoma of the tongue 5.6
Fibrosarcoma 5.6
BLM 5.5
Postoperative cognitive dysfunction 5.5
trichothiodystrophy 5.5
Testicular torsion 5.4
LCS 5.4
Cockayne syndrome 5.4
Chemoradiation 5.4
Middle cerebral artery occlusion 5.3
CDT 5.3
ATRX 5.2
Selenium deficiency 5.2
testicular atrophy 5.2
xeroderma pigmentosum 5.2
FRAXA 5.2
XPG 5.1
Shigella boydii 5.1
malignant meningioma 5.1
HNSCC 5.1
Spitz nevus 5.1
vaginal cancer 5.0
PML 4.9
MIN 4.9
MIN 4.9
Ovary 4.9
RSS 4.9
glioblastoma 4.8
BFR 4.8
tobacco abuse 4.8
BPP 4.8
CEP 4.8
HCC 4.8
neoplastic transformation 4.7
Desmoplastic small round cell tumor 4.7
hormone refractory prostate cancer 4.7
Rhabdomyosarcoma 4.7
Meningioma 4.6
Meningioma 4.6
CYLD 4.6
recurrent prostate cancer 4.6
Esophageal squamous cell carcinoma 4.6
Abdomen 4.6
refractory CLL 4.5
melanoma in situ 4.5
Severe sepsis 4.5
DSS 4.5
spindle cell sarcoma 4.5
HMR 4.5
Glioblastoma 4.5
Fallopian tube 4.5
HOS 4.4
SMC 4.4
MCF 4.3
CIN 4.3
dysplastic nevi 4.3
NLS 4.3
renal clear cell carcinoma 4.3
glioblastoma multiforme 4.3
FDH 4.3
T-cell acute lymphoblastic leukemia 4.3
DSS 4.2
acute monocytic leukemia 4.2
MRD 4.2
AGS 4.2
MTS 4.2
Ovary 4.1
non-small cell lung cancer 4.1
benign nevi 4.1
chancroid 4.1
EMT 4.1
immunotoxicity 4.1
LMS 4.0
LMS 4.0
colon cancer 4.0
carcinogenesis 4.0
SCID 4.0
Testes 4.0
pediatric brain tumor 4.0
HML 4.0
HGF 4.0
Leiomyosarcoma 4.0
western equine encephalomyelitis 4.0
TAS 4.0
glioma 4.0
retinoblastoma 3.9
tumorigenesis 3.9
premalignant condition 3.9
Osteosarcoma 3.9
Osteosarcoma 3.9
osteosarcoma 3.9
malignant mesothelioma 3.9
seborrheic keratosis 3.9
oligospermia 3.8
myeloid leukemia 3.8
tumor growth 3.8
oropharyngeal squamous cell carcinoma 3.8
esophageal cancer 3.8
Barrett's esophagus 3.8
ovarian cancer 3.8
cervical cancer 3.8
Cowden syndrome 3.8
Common variable immunodeficiency 3.7
mantle cell lymphoma 3.7
more...
Symptom
Halo 4.1
skin damage 4.0
CSR 3.5
collapse 2.6
hyperoxia 2.6
ataxia 2.5
cerebellar ataxia 2.2
bradykinesia 1.8
exhaustion 1.6
starvation 0.7
hypothermia 0.5
overweight -0.1
respiratory distress -0.3
splenomegaly -0.3
thinning -0.5
diarrhea -0.5
erythema -0.7
anorexia -0.8
acidity -0.9
seizures -1.3
discomfort -1.5
nausea -1.5
cough -1.6
discomfort -1.6
vomiting -2.0
fatigue -2.7
pain -3.4
anesthesia -3.8
Drug
Irofulven 9.0
Tricyclazole 8.3
Adozelesin 8.2
Trabectedin 7.4
Epalrestat 7.4
Vorinostat 7.3
Crotonaldehyde 7.3
Sodium ascorbate 7.2
Tipifarnib 6.9
Ciglitazone 6.7
Truvada 6.6
Tolfenamic acid 6.6
7-Nitroindazole 6.5
Tirapazamine 6.5
Mizoribine 6.4
Etoposide 6.3
Mutagen 6.3
Neocarzinostatin 6.2
BLM 6.2
Sesamol 6.1
TFT 6.0
Hyperforin 5.9
Cidofovir 5.9
Areca 5.9
Saha 5.9
Clofarabine 5.9
Oxaliplatin 5.7
Myricetin 5.7
Panitumumab 5.6
PFT 5.6
Podophyllum 5.6
2-Methoxyestradiol 5.6
Dexrazoxane 5.6
Artesunate 5.6
Truvada 5.5
Gatifloxacin 5.5
Gemzar 5.4
ROS 5.4
Mitomycin-C 5.3
Tolvaptan 5.2
Entecavir 5.2
Entecavir 5.2
Cytidine 5.1
Ammonium chloride 5.1
Arsenic trioxide 5.0
Propidium 5.0
Dihydro 5.0
Levovist 4.9
Silica gel 4.8
Bortezomib 4.8
Taxotere 4.7
Erlotinib 4.4
CPT-11 4.4
Rosiglitazone 4.3
Irinotecan 4.3
Aminoguanidine 4.3
Emodin 4.1
Cetuximab 4.1
NVP 4.1
caffeine 4.0
balanced salt solution 4.0
Troglitazone 3.9
Emodin 3.8
Dasatinib 3.7
TTC 3.7
VCR 3.7
Kainic acid 3.6
ZnCl2 3.6
ZnCl2 3.6
ETS 3.6
Lovastatin 3.6
MRC 3.6
ADR 3.6
-deoxyadenosine 3.5
Everolimus 3.5
Sorafenib 3.4
Herceptin 3.4
Adriamycin 3.4
GEO 3.4
Zoledronic acid 3.3
Pravastatin 3.3
lysine 3.3
Docetaxel 3.2
DBS 3.2
Gastro 3.2
Reserpine 3.0
Check 3.0
PFA 3.0
DNase I 3.0
CTC 2.9
AraC 2.9
Glutathione 2.9
G418 2.9
DMAP 2.8
HCH 2.8
Imatinib 2.7
Vitamin B 2.7
Indomethacin 2.7
CTC 2.7
Nitric Oxide 2.6
AZT 2.6
Gleevec 2.5
MOF 2.4
AZT 2.4
VCR 2.4
TAC 2.3
Vitamin E 2.3
Parkin 2.1
Parkin 2.1
ascorbate 2.1
ACT 1.9
Paraffin 1.9
Estrogens 1.8
ZnO 1.8
Fragment 1.8
Silica 1.8
TAT 1.8
Albumin 1.8
Fraction 1.7
Forskolin 1.6
G-CSF 1.6
Fluorescein 1.6
Alanine 1.5
ALA 1.5
Rituximab 1.5
Heme 1.4
MAP 1.4
Taxol 1.3
CTX 1.3
Fluorescein 1.1
TiO2 1.1
p75 1.1
PCB 0.9
ENT 0.9
Gel 0.7
Angiotensin II 0.7
FAD 0.6
CAM 0.5
Monit 0.5
vitamin E 0.5
Bifidobacterium 0.5
PTH 0.2
NH3 0.2
EPA 0.2
NADH 0.1
ROC 0.1
EE2 0.1
THF -0.0
ampicillin -0.1
Ethanol -0.3
CSF -0.3
Leaf -0.4
lactose -1.0
Nephron -1.1
Dermatol -1.8
IL-2 -1.8
Cardiovasc -4.6
Enzyme
CYP39A1 8.8
PARP 7.2
RNase D 6.9
10-formyltetrahydrofolate dehydrogenase 6.9
CSAD 6.7
topoisomerase 6.4
topoisomerase 6.4
caspase-2 6.4
caspase-2 6.3
CYP7B1 6.0
nicotinamide mononucleotide adenylyltransferase 6.0
endodeoxyribonuclease 5.9
deoxyguanosine kinase 5.8
caspase-7 5.8
arachidonate 5-lipoxygenase 5.8
caspase-7 5.7
histone acetyltransferase 5.6
caspase-3 5.6
caspase-4 5.5
carboxypeptidase G2 5.5
valyl-tRNA synthetase 5.4
caspase-4 5.3
poly(ADP-ribose) glycohydrolase 5.3
endonuclease VII 5.3
DNA ligase 5.3
DNA ligase 5.3
glutathione synthetase 5.2
phosphatidylethanolamine N-methyltransferase 5.2
methylthioadenosine phosphorylase 5.1
STK11 5.1
guanase 5.1
caspase-8 5.1
GAR 5.0
cytosine deaminase 5.0
CEP 5.0
O-GlcNAc transferase 5.0
dihydroorotate dehydrogenase 5.0
protein phosphatase 2A 5.0
dihydroorotate dehydrogenase 5.0
polo-like kinase 1 5.0
cdc2 5.0
ubiquitin-protein ligase 4.9
caspase-9 4.9
pyruvate oxidase 4.9
pyruvate oxidase 4.9
isopeptidase 4.8
ribonucleotide reductase 4.8
PHD 4.8
ALDH 4.8
ribonucleotide reductase 4.8
Fpg protein 4.6
Lys4 4.5
deoxycytidine kinase 4.5
CEP 4.5
DNA methyltransferase 4.4
DCF 4.4
biotinidase 4.4
3'-exonuclease 4.3
HCS 4.3
hypoxanthine-guanine phosphoribosyltransferase 4.3
endonuclease 4.3
histone demethylase 4.1
caspase-6 4.1
phosphoinositide 3-kinase 4.1
cytidine deaminase 4.0
thioredoxin reductase 4.0
cathepsin S 4.0
caspase-6 4.0
asparagine synthetase 4.0
angiotensin-converting enzyme 2 4.0
NQO1 4.0
farnesyltransferase 4.0
HK2 3.9
micrococcal nuclease 3.8
prenyltransferase 3.8
calcineurin 3.8
CDH 3.8
1-hydroxylase 3.8
serine hydroxymethyltransferase 3.8
prenyltransferase 3.8
MTD 3.8
thymidylate synthase 3.8
HDR 3.7
prenyltransferase 3.7
xanthine dehydrogenase 3.7
factor C 3.7
porphobilinogen deaminase 3.7
polynucleotide kinase 3.6
DNA polymerase 3.6
adenine phosphoribosyltransferase 3.5
gamma-glutamylcysteine synthetase 3.5
protein kinase 3.5
deoxyribonuclease 3.5
MAT 3.4
farnesyltransferase 3.4
proteasome 3.4
AMPK 3.4
mitogen-activated protein kinase 3.3
methionine synthase 3.3
PST 3.3
PAT 3.3
phosphatidylinositol 3-kinase 3.3
MAT 3.2
KAT 3.2
peroxiredoxin 3.2
Pla 3.2
IMP dehydrogenase 3.2
methionine synthase 3.2
beta-galactosidase 3.1
MPP 3.1
TdT 3.1
PRE 3.1
cystathionine beta-synthase 3.1
GSK 3.1
MEK 3.0
nucleotidase 3.0
thymidine phosphorylase 3.0
cathepsin B 3.0
ECH 2.9
AMP-activated protein kinase 2.9
matrix metalloproteinase 9 2.9
flavin-containing monooxygenase 2.9
superoxide dismutase 2.9
PDK1 2.9
3-hydroxy-3-methylglutaryl-CoA reductase 2.9
GRK5 2.8
ERK 2.8
catalase 2.7
DNase 2.7
cathepsin D 2.6
demethylase 2.6
heme oxygenase 2.5
TPP 2.5
glyceraldehyde-3-phosphate dehydrogenase 2.5
glyceraldehyde-3-phosphate dehydrogenase 2.5
glucocerebrosidase 2.5
MAP 2.5
deoxyribonuclease 2.4
triphosphatase 2.4
apyrase 2.4
AMPK 2.4
glyceraldehyde-3-phosphate dehydrogenase 2.4
CPT 2.3
succinate dehydrogenase 2.3
alpha-galactosidase 2.3
CPT 2.2
aconitase 2.2
prostate-specific membrane antigen 2.2
luciferase 2.2
MEKK1 2.1
PAM 2.1
glyceraldehyde-3-phosphate dehydrogenase 2.1
thymidine kinase 2.1
RNA polymerase 2.1
adenylate kinase 2.1
glutathione peroxidase 2.0
CYP3A4 1.9
glyceraldehyde-3-phosphate dehydrogenase 1.9
CAD 1.9
focal adhesion kinase 1.9
more...
Compound
2-(4-chlorophenyl)benzo-1,4-quinone 12.4
Avenanthramide A 12.0
Eurycomalactone 11.4
Ara-HA 11.0
2'-Hydroxychalcone 11.0
Tebufenpyrad 9.8
Quinalizarin 9.5
Resmethrin 9.5
Microcephalin 9.5
Hedamycin 9.4
Aeroplysinin-1 9.2
Ovatodiolide 9.1
Myosmine 9.1
2,4-DMA 9.0
Butylidenephthalide 8.5
Angelicin 8.5
Saikosaponin A 8.5
Phosphoramide mustard 8.4
Rafoxanide 8.3
Myristicin 8.3
Solanine 8.3
Lanatoside C 8.2
MINA 8.2
1H-benzo[de]isoquinoline-1,3(2H)-dione 8.1
Solanine 8.1
Chloranil 8.0
Plastoquinone 7.9
MTIC 7.9
Fostriecin 7.8
Amentoflavone 7.6
4-methoxybenzaldehyde 7.6
Nitidine 7.6
4-methoxybenzaldehyde 7.6
4-methoxybenzaldehyde 7.5
4-methoxybenzaldehyde 7.5
4-methoxybenzaldehyde 7.5
beta-Lapachone 7.5
4-methoxybenzaldehyde 7.5
7H-dibenzo[c,g]carbazole 7.4
4-methoxybenzaldehyde 7.4
Diepoxybutane 7.4
1,2,4-benzotriazine 7.4
G 1 7.4
hydroxymethylbilane 7.3
4-methoxybenzaldehyde 7.3
Methyleugenol 7.3
4-methoxybenzaldehyde 7.3
Histone 7.2
Phenanthrenequinone 7.2
Anacardic acid 7.2
Juglone 7.1
Potassium bromate 7.0
10-Hydroxycamptothecin 7.0
Carnosol 7.0
Dihydromyricetin 6.9
8-hydroxyguanosine 6.9
HN2 6.9
XPA 6.9
1,2-dichloropropane 6.9
XPA 6.9
Nedaplatin 6.8
Camptothecin 6.8
Camptothecin 6.8
Camptothecin 6.8
Bufalin 6.7
2-methylquinoline 6.6
hydrazinecarbothioamide 6.6
Methacrylic acid 6.6
Azoxymethane 6.6
GRG 6.5
Propylparaben 6.5
Cepharanthine 6.5
Trifluorothymidine 6.5
2-methylquinoline 6.4
methyl methanesulfonate 6.4
DMAE 6.4
8-OHdG 6.4
Hyperoside 6.3
IBT 6.3
Neocarzinostatin 6.2
Calyculin A 6.2
Cyclopamine 6.2
DHM 6.2
PBD 6.2
TIF 6.2
2-butenal 6.2
Bisphenol S 6.1
ADP-ribose 6.1
Sesamol 6.1
Temozolomide 6.1
2-phenoxyethanol 6.1
dUDP 6.1
5-Aza-2'-deoxycytidine 6.1
Ribose 6.1
Microcystin-LR 6.1
Z-Gly 6.0
NOXA 6.0
Cidofovir 6.0
Tetrandrine 6.0
Tetrandrine 6.0
Tetrandrine 6.0
Tetrandrine 6.0
Oxymatrine 6.0
benzo[c]phenanthridine 6.0
Topotecan 5.9
3-chlorophenol 5.9
TFT 5.9
Hyperforin 5.9
Prodigiosin 5.9
Prodigiosin 5.9
UDMA 5.9
1,2,4-benzenetriol 5.8
Carcinogen 5.8
TFF 5.8
Methoxychlor 5.8
Cordycepin 5.8
Cordycepin 5.8
Cordycepin 5.7
Methylparaben 5.7
Carnosic acid 5.7
Honokiol 5.7
alpha-Naphthoflavone 5.7
alpha-Naphthoflavone 5.7
PCB 126 5.7
alpha-Naphthoflavone 5.6
Phorbol-12-myristate-13-acetate 5.6
Isoliquiritigenin 5.6
Triptolide 5.6
Sitosterol 5.6
2-Methoxyestradiol 5.6
Paeonol 5.6
[1,10]phenanthroline 5.6
PAR 5.6
Gatifloxacin 5.6
Withaferin A 5.5
Ginsenoside Rg1 5.5
8-quinolinol 5.5
BLM 5.4
Sanguinarine 5.4
Fucoxanthin 5.4
Topotecan 5.4
Sulforaphane 5.4
Dehydroascorbic acid 5.3
SHB 5.3
ICRF-187 5.3
Pyrogallol 5.3
10-formyltetrahydrofolate 5.3
Oridonin 5.3
Ochratoxin A 5.3
Serine 5.3
Tempol 5.3
VP-16 5.3
Tauroursodeoxycholic acid 5.3
Norethisterone 5.2
8-quinolinol 5.2
GAR 5.2
CDT 5.2
SN-38 5.2
Pyrrolizidine 5.2
Salinomycin 5.2
more...