Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P16104 (H2AX)
 3,930 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
H2AX 3930
histone 1173
p53 711
ATM 606
Mol 448
53BP1 322
ATR 284
caspase-3 275
Chk1 262
DNA-dependent protein kinase 262
Sep 245
p21 233
PARP 209
BRCA1 209
Chk2 179
ataxia telangiectasia mutated 143
Rad51 134
RAD51 130
A-T 126
MDC1 123
ROS 99
Bcl-2 93
histone H2A 92
NBS1 88
histone H3 85
H2A 77
CHK2 74
Ku70 72
p38 68
PARP-1 68
CHK1 66
histone deacetylase 63
ubiquitin 62
poly(ADP-ribose) polymerase 60
phosphatase 59
telomeric 58
ATP 58
proliferating cell nuclear antigen 58
Rad50 57
MRE11 57
JNK 55
topoisomerase I 55
annexin V 55
Ku80 53
AKT 46
p16 46
TNF 45
PI3K 45
endonuclease 44
BRCA2 43
ADP 42
ERK 42
catalase 41
PARP1 40
RNF8 39
caspase-9 39
caspase-8 38
H2A.X 38
mTOR 38
proteasome 37
RAD50 36
RPA 36
superoxide dismutase 36
MAPK 35
helicase 35
IL-6 34
histone protein 34
threonine 33
cyclin D1 32
cytochrome c 32
FANCD2 30
survivin 29
osteosarcoma 29
cyclin B1 29
ERK1 28
phosphorylating 27
p53 binding protein 27
BAX 26
RNF168 26
PUMA 26
ubiquitin ligase 25
DNA repair protein 25
poly (ADP-ribose) polymerase 24
TRF2 24
cytochrome 23
DNA polymerase 23
MMP-9 23
GSH 23
NADPH oxidase 1 23
p27 23
cytokine 23
c-Myc 22
WAF1 22
CDKN1A 22
LC3 22
CDK2 22
H2B 21
XRCC4 21
cyclin E 21
ATPase 21
hTERT 21
E3 ubiquitin ligase 21
HDAC 21
endoplasmic reticulum 20
like kinase 20
Ki-67 20
cyclin 20
PC3 20
Poly 20
XRCC1 20
NAD 20
CtIP 19
CDK1 19
SOD 19
inducible nitric oxide synthase 19
cyclin A 19
cyclin-dependent kinase 19
lymphoid 19
colon carcinoma 18
histone H4 18
membrane-bound 18
Mcl-1 18
methylguanine-DNA methyltransferase 17
apoptosis-inducing factor 17
RPA32 17
p202 17
PTEN 17
H2A histone family member 17
histone H2B 16
c-Jun 16
histone acetyltransferase 16
PML 16
RPA2 16
SWI 16
thymus 16
PAR 15
CYP1A1 15
ATM protein 15
MLH1 15
epidermal growth factor receptor 15
NFBD1 15
Poly(ADP-ribose) polymerase 15
interacting protein 15
XPA 15
EGFR 15
p16INK4a 15
SMC1 15
DNA topoisomerase I 15
SYCP3 15
protein phosphatase 15
DDR 15
CD34 14
VEGF 14
nuclear protein 14
tyrosine kinase 14
Histone deacetylase 14
p65 14
Ku86 14
E2F1 14
proteasome inhibitor 14
more...
Disease
cancer 1156
ATM 706
tumor 634
breast cancer 201
carcinogenesis 130
tumorigenesis 108
carcinoma 104
tumor growth 102
lung cancer 92
leukemia 88
MCF 71
prostate cancer 69
glioblastoma 64
adenocarcinoma 63
colorectal cancer 62
glioma 59
hepatocellular carcinoma 58
colon cancer 58
non-small cell lung cancer 48
melanoma 48
ovarian cancer 47
tumor progression 44
lymphoma 40
cervical cancer 37
acute myeloid leukemia 34
squamous cell carcinoma 33
pancreatic cancer 32
osteosarcoma 30
anemia 30
Fanconi 28
neuroblastoma 23
GSH 23
glioblastoma multiforme 22
SCID 22
ischemia 22
lung carcinoma 21
B-cell lymphoma 21
NBS 21
retinoblastoma 21
multiple myeloma 19
immunodeficiency 19
premature aging 19
chronic lymphocytic leukemia 19
gastric cancer 19
sarcoma 18
chronic lymphocytic leukemia 17
liver cancer 17
BLM 17
WRN 17
neoplastic transformation 16
bladder cancer 16
PML 16
FHA 16
genetic disorder 14
skin cancer 14
esophageal cancer 14
esophageal cancer 14
xeroderma pigmentosum 13
Leukemia 13
HIV 12
chronic myeloid leukemia 12
Blocking 12
acute promyelocytic leukemia 12
diabetes 12
renal cell carcinoma 11
infertility 11
acute lymphoblastic leukemia 11
XPD 10
metastases 10
myelodysplastic syndrome 10
HP1 10
Alzheimer's disease 10
Epstein 10
HCC 10
Melanoma 9
Barrett's esophagus 9
Huntington's disease 9
hematologic malignancies 9
epithelial ovarian cancer 9
obesity 9
fibrosarcoma 9
virus infection 8
infectious diseases 8
cold 8
astrocytoma 8
oral cancer 8
head and neck cancer 8
XPF 8
DDP 8
liver cancer 8
progeria 8
Glioblastoma 8
Parkinson's disease 7
Infection 7
dysplasia 7
atherosclerosis 7
cognitive impairment 7
malnutrition 7
adenoma 7
solid tumor 7
myeloid leukemia 7
SDS 7
brain tumor 7
APC 6
Hodgkin's disease 6
male infertility 6
Cockayne syndrome 6
hepatitis B 6
MTS 6
mantle cell lymphoma 6
small cell lung cancer 6
stroke 6
EMT 6
MCPH1 6
T-cell acute lymphoblastic leukemia 6
parvovirus 6
CEM 6
NOD 5
aggressiveness 5
mesothelioma 5
mental retardation 5
Ewing's sarcoma 5
malignant mesothelioma 5
stromal tumors 5
AGS 5
osteoporosis 5
amyotrophic lateral sclerosis 5
HGF 5
papilloma 5
cytomegalovirus 5
acute leukemia 5
hyperglycemia 5
mental retardation 5
Hepatocellular carcinoma 5
B-cell lymphomas 5
heart failure 5
CREST 5
Osteosarcoma 4
Osteosarcoma 4
Esophageal squamous cell carcinoma 4
rhabdomyosarcoma 4
metastatic breast cancer 4
mole 4
immunotoxicity 4
DSS 4
testicular atrophy 4
SEM 4
fallopian tube 4
Ovary 4
medulloblastoma 4
herpes simplex 4
dementia 4
epilepsy 4
thyroid cancer 4
pneumonia 4
metabolic syndrome 4
leukemogenesis 4
Pineal 4
Recruitment 4
radiation carcinogenesis 4
more...
Symptom
collapse 22
ataxia 11
starvation 5
diarrhea 5
exhaustion 5
seizures 4
hyperoxia 4
overweight 3
hypothermia 3
pain 3
skin damage 3
respiratory distress 2
cerebellar ataxia 2
cough 1
discomfort 1
nausea 1
anesthesia 1
Halo 1
anorexia 1
bradykinesia 1
thinning 1
discomfort 1
acidity 1
splenomegaly 1
erythema 1
vomiting 1
CSR 1
fatigue 1
Drug
ROS 99
lysine 69
Mutagen 57
caffeine 43
ascorbate 12
BLM 12
Etoposide 11
Dermatol 9
DNase I 8
Vorinostat 7
ZnO 6
Adriamycin 6
Monit 6
Oxaliplatin 6
Glutathione 5
Bortezomib 5
CPT-11 5
MAP 5
MRC 5
Indomethacin 5
Arsenic trioxide 5
ETS 4
vitamin E 3
balanced salt solution 3
TiO2 3
Trabectedin 3
NADH 3
TTC 3
ADR 3
CTX 3
Gel 3
Herceptin 3
-deoxyadenosine 3
HCH 3
CSF 3
PFT 3
Areca 2
AZT 2
Cetuximab 2
ZnCl2 2
Myricetin 2
Sorafenib 2
G-CSF 2
Nitric Oxide 2
ampicillin 2
ZnCl2 2
ENT 2
Rosiglitazone 2
GEO 2
Leaf 2
Irofulven 2
MOF 2
Imatinib 2
NVP 2
Artesunate 2
Irinotecan 2
Taxotere 2
AZT 2
Docetaxel 2
Check 2
TFT 2
Cidofovir 2
Lovastatin 2
Erlotinib 2
Dihydro 2
G418 2
Vitamin E 2
Albumin 2
Gleevec 1
Troglitazone 1
Panitumumab 1
Fluorescein 1
Taxol 1
p75 1
DBS 1
Fraction 1
Entecavir 1
Fragment 1
Epalrestat 1
Silica gel 1
Gatifloxacin 1
PTH 1
EPA 1
Pravastatin 1
Forskolin 1
Emodin 1
VCR 1
Heme 1
Zoledronic acid 1
Sesamol 1
DMAP 1
Alanine 1
PFA 1
AraC 1
lactose 1
2-Methoxyestradiol 1
CTC 1
Nephron 1
Neocarzinostatin 1
Ammonium chloride 1
Everolimus 1
Truvada 1
Levovist 1
Parkin 1
Cytidine 1
Mitomycin-C 1
Hyperforin 1
Tirapazamine 1
Aminoguanidine 1
ROC 1
Fluorescein 1
Dasatinib 1
Gemzar 1
Tipifarnib 1
Ethanol 1
Mizoribine 1
Bifidobacterium 1
Cardiovasc 1
THF 1
FAD 1
Gastro 1
EE2 1
Tolvaptan 1
Sodium ascorbate 1
Ciglitazone 1
Saha 1
7-Nitroindazole 1
Dexrazoxane 1
Estrogens 1
Vitamin B 1
PCB 1
Parkin 1
TAT 1
Paraffin 1
Kainic acid 1
CAM 1
Rituximab 1
Podophyllum 1
Crotonaldehyde 1
Tolfenamic acid 1
Propidium 1
Truvada 1
Silica 1
Entecavir 1
Adozelesin 1
Tricyclazole 1
VCR 1
CTC 1
Clofarabine 1
Angiotensin II 1
ACT 1
IL-2 1
NH3 1
Reserpine 1
ALA 1
Emodin 1
TAC 1
Enzyme
PARP 255
caspase-3 208
mitogen-activated protein kinase 117
protein kinase 112
topoisomerase 103
topoisomerase 96
ERK 84
superoxide dismutase 53
catalase 45
endonuclease 44
proteasome 37
cdc2 32
calcineurin 30
caspase-8 29
caspase-9 28
DNA polymerase 25
ATPase 22
luciferase 21
focal adhesion kinase 20
RNA polymerase 18
MEK 18
histone acetyltransferase 16
beta-galactosidase 16
DNA ligase 13
DNA methyltransferase 13
DNA ligase 13
phosphatidylinositol 3-kinase 13
protein phosphatase 2A 12
NQO1 12
AMP-activated protein kinase 12
lactate dehydrogenase 12
phosphoinositide 3-kinase 12
glutathione peroxidase 11
ribonucleotide reductase 10
ribonucleotide reductase 10
protein kinase C 8
caspase-2 8
AMPK 8
AMPK 8
caspase-2 8
glutathione S-transferase 7
GSK 7
peroxidase 6
hypoxanthine-guanine phosphoribosyltransferase 6
polo-like kinase 1 6
caspase-7 6
RNase 6
thymidylate synthase 6
ACS 6
alanine aminotransferase 6
APC 6
DNase 6
caspase-7 6
micrococcal nuclease 5
MAP 5
succinate dehydrogenase 5
collagenase 5
thioredoxin reductase 5
DCF 5
phosphodiesterase 5
NADPH oxidase 5
reverse transcriptase 4
RNase 4
thymidine kinase 4
glutathione reductase 4
complex I 4
NADPH oxidase 4
aspartate aminotransferase 4
demethylase 4
cathepsin B 4
glyceraldehyde-3-phosphate dehydrogenase 3
transcriptase 3
NOS 3
glyceraldehyde-3-phosphate dehydrogenase 3
ubiquitin-protein ligase 3
glyceraldehyde-3-phosphate dehydrogenase 3
glyceraldehyde-3-phosphate dehydrogenase 3
CEP 3
glutathione synthetase 3
alkaline phosphatase 3
peroxiredoxin 3
cathepsin D 3
heme oxygenase 3
CEP 3
cytosine deaminase 3
P-glycoprotein 3
glyceraldehyde-3-phosphate dehydrogenase 3
CYP3A4 3
PHD 3
ALDH 3
caspase-1 2
monoamine oxidase 2
PDK1 2
farnesyltransferase 2
deoxyribonuclease 2
caspase-4 2
farnesyltransferase 2
MPP 2
CAD 2
gamma-glutamylcysteine synthetase 2
cytochrome oxidase 2
STK11 2
tissue plasminogen activator 2
matrix metalloproteinase 9 2
PRE 2
histone demethylase 2
glucose-6-phosphate dehydrogenase 2
deoxycytidine kinase 2
MAT 2
isopeptidase 2
dihydroorotate dehydrogenase 2
xanthine dehydrogenase 2
angiotensin-converting enzyme 2 2
AST 2
dihydroorotate dehydrogenase 2
CPT 2
MAT 2
O-GlcNAc transferase 2
caspase-4 2
CPT 2
CAD 2
CPT 2
cytidine deaminase 2
CAD 2
xanthine oxidase 2
MDR 2
IKK 2
TdT 2
NO synthase 1
cathepsin S 1
thymidine phosphorylase 1
aconitase 1
adenine phosphoribosyltransferase 1
trypsin 1
KAT 1
GRK5 1
CDR 1
Lys4 1
triphosphatase 1
3'-exonuclease 1
pyruvate oxidase 1
endonuclease VII 1
prenyltransferase 1
prenyltransferase 1
ADH 1
asparaginase 1
RNase H 1
MEKK1 1
caspase-6 1
ribonuclease 1
HDR 1
apyrase 1
TPP 1
pyruvate oxidase 1
PAT 1
firefly luciferase 1
flavin-containing monooxygenase 1
chitinase 1
biotinidase 1
ribonuclease 1
more...
Compound
DNA 3417
oxygen 355
Dec 265
serine 227
Histone 91
lysine 77
hydrogen 65
MTT 62
cysteine 62
ATP 58
MDA 53
threonine 52
ADP-ribose 51
ADP 45
water 45
TNF 45
N-acetylcysteine 44
caffeine 43
ADP 42
ADP 42
iodine 41
H2O2 40
tyrosine 33
8-OHdG 33
sodium 33
pyrene 32
iron 32
Clin 29
GSH 28
GSH 28
Adriamycin 27
methyl methanesulfonate 25
ADR 24
diacetate 23
calcium 23
NAD 22
dUTP 22
nitric oxide 22
nitrogen 21
NAD 20
phosphate 19
Serine 16
bromide 16
VP-16 15
BLM 15
pyrimidine 15
XPA 15
pyrimidine 15
DDP 15
alanine 15
PAR 15
XPA 15
arginine 14
copper 14
chromium 14
glucose 14
acetate 13
hydroquinone 13
MEK 12
Resveratrol 12
zinc 12
boron 12
benzene 11
DMSO 11
ethanol 11
cAMP 10
acridine 10
salt 10
creatinine 9
MIA 9
nicotinamide 9
silver 9
formaldehyde 9
Curcumin 9
silicon 9
anthracene 8
sulfate 8
urea 8
Camptothecin 8
Camptothecin 8
Camptothecin 8
SDS 7
Bisphenol A 7
methanol 7
quinoline 7
Gemcitabine 7
BNP 7
CAT 7
Carbon 7
THP 7
Panam 7
Gemcitabine 7
Bisphenol A 7
quinoline 7
MTS 7
phenol 7
THP 7
Temozolomide 7
Hoechst 33342 7
MMC 6
retinoic acid 6
methane 6
pyridine 6
ACS 6
HN2 6
cadmium 6
ACS 6
5-FU 6
Valproic acid 6
2-hydroxyethyl 5
2-hydroxyethyl 5
GSSG 5
formaldehyde 5
2-hydroxyethyl 5
Ochratoxin A 5
CPT-11 5
2-hydroxyethyl 5
MAP 5
Melatonin 5
SN-38 5
5-Aza-2'-deoxycytidine 5
SCC 5
PEG 5
2-hydroxyethyl 5
G 1 5
cobalt 5
2-hydroxyethyl 5
His 5
Ubiquitin 5
2-hydroxyethyl 5
glutamine 5
CAT 5
naphthalene 5
APAP 5
AMP 5
Asp 5
CAT 5
Pac 5
2-hydroxyethyl 5
NH2 5
aflatoxin B1 5
galactose 5
manganese 5
Sulforaphane 4
BCNU 4
chalcone 4
DSS 4
Epigallocatechin gallate 4
phosphoserine 4
CuO 4
aniline 4
NADPH 4
Hydroxyurea 4
vitamin D 4
hydrazine 4
Emodin 4
Microcephalin 4
selenium 4
NADPH 4
fluorine 4
more...