Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P16104 (
H2AX
)
3,930
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Ataxia-telangiectasia mutated (ATM) is a cell cycle checkpoint kinase that upon activation by DNA damage leads to cell cycle arrest and DNA repair or apoptosis. The absence of Atm or the occurrence of loss-of-function mutations in Atm predisposes to tumorigenesis.
MAPK7
has been implicated in numerous types of cancer with pro-survival and pro-growth roles in tumor cells, but its functional relation with tumor suppressors is not clear. In this study, we show that absence of
MAPK7
delays death due to spontaneous tumor development in Atm-/- mice. Compared with Atm-/- thymocytes, Mapk7-/-Atm-/- thymocytes exhibited an improved response to DNA damage (increased phosphorylation of
H2AX
) and a restored apoptotic response after treatment of mice with ionizing radiation. These findings define an antagonistic function of ATM and
MAPK7
in the thymocyte response to DNA damage, and suggest that the lack of
MAPK7
inhibits thymic lymphoma growth in Atm-/- mice by partially restoring the DNA damage response in thymocytes.
...
PMID:Absence of ERK5/MAPK7 delays tumorigenesis in Atm-/- mice. 2821 85
