Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P16104 (
H2AX
)
3,930
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Activating transcription factor 2
(
ATF2
) is regulated by JNK/p38 in response to stress. Here, we demonstrate that the protein kinase ATM phosphorylates
ATF2
on serines 490 and 498 following ionizing radiation (IR). Phosphoantibodies to
ATF2
(490/8) reveal dose- and time-dependent phosphorylation of
ATF2
by ATM that results in its rapid colocalization with gamma-
H2AX
and MRN components into IR-induced foci (IRIF). Inhibition of
ATF2
expression decreased recruitment of Mre11 to IRIF, abrogated S phase checkpoint, reduced activation of ATM, Chk1, and Chk2, and impaired radioresistance.
ATF2
requires neither JNK/p38 nor its DNA binding domain for recruitment to IRIF and the S phase checkpoint. Our findings identify a role for
ATF2
in the DNA damage response that is uncoupled from its transcriptional activity.
...
PMID:ATM-dependent phosphorylation of ATF2 is required for the DNA damage response. 1591 64
