Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P15088 (mast cell)
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Human Gene/Protein
mast cell 11.1
G-protein-coupled receptor 34 11.1
PI4KAP1 11.1
Tryptase I 11.1
tryptase I 11.1
MC-CPA 11.1
mMCP-7-like I 11.1
CAPPA1 11.1
carboxypeptidase A3 10.6
mast cell protease I 10.5
MAS-related G protein-coupled receptor 10.4
MRGPRX2 10.3
beta-tryptase 10.2
mast cell protease II 10.1
peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor 10.1
mitogen- and stress-activated protein kinase 2 10.1
Mast cell tryptase 10.1
sialyltransferase 4C 10.1
Endothelial collagen 10.1
LAD2 10.0
FcERI 9.8
Carboxypeptidase A 9.8
skin tryptase 9.8
CPA3 9.8
mast cell tryptase 9.6
chymase 9.6
TPSAB1 9.6
TSBP 9.5
TPSB2 9.5
CPA5 9.5
C12orf4 9.5
Transient receptor potential cation channel, subfamily V, member 4 9.5
EN-7 9.5
SCAMP-4 9.5
protease E) 9.5
fibronectin leucine rich transmembrane protein 3 9.5
STXBP2 protein 9.5
CERK protein 9.5
FceRI 9.4
Chymase 9.3
stem cell factor, SCF 9.3
beta II 9.1
squamous cell carcinoma antigen 2 9.1
txk 9.1
C48 9.1
exophilin-8 9.1
CLMF 9.1
NTAL 9.0
Syt V 8.7
Coronin-1B 8.7
P2Y10 8.7
MS4A4 8.7
Ubiquitin-protein ligase 8.7
ASPA protein 8.7
diphosphoinositide kinase 8.7
ACLP 8.7
Interleukin 9 8.7
tryptase beta I 8.6
HYAL4 8.6
Fc epsilon RI alpha-chain 8.6
MS4A2 8.6
CMA1 8.5
CYH 8.5
Mast cell growth factor 8.5
HYALP1 8.5
MUNC18-2 8.5
MBPH 8.5
R-ras3 8.5
acylase III 8.5
potassium inwardly-rectifying channel 8.5
LILRB5 8.5
serglycin 8.4
Siglec-8 8.4
IGLJ3 8.3
carboxypeptidase O 8.3
64kDa) 8.3
histamine receptor H3 8.3
tryptase epsilon 8.3
kit-ligand 8.1
FCER1A 8.1
more...
Disease
Idiopathic angioedema 11.1
Neutrophilic urticaria 11.1
Allergic gastroenteritis and colitis 11.1
SM-AHNMD 10.6
Malignant mastocytosis 10.5
Seasonal allergic conjunctivitis 10.3
Systemic mastocytosis 10.1
mast cell leukemia 10.1
Complete atelectasis 10.1
Chronic allergic conjunctivitis 10.1
Perennial allergic conjunctivitis 10.1
Mastocytosis 10.0
Atopic keratoconjunctivitis 9.9
mastocytosis 9.8
urticaria pigmentosa 9.7
Cutaneous mastocytosis 9.6
Telangiectasia macularis eruptiva perstans 9.6
LAD2 9.5
Chronic autoimmune urticaria 9.5
Atopic allergy 9.5
Heteroplasia 9.5
Familial mastocytosis 9.5
Idiopathic anaphylaxis 9.5
Acral lick dermatitis 9.1
Solitary mastocytoma 9.1
MPD3 9.1
Chronic idiopathic urticaria 8.9
Mastocytoma 8.9
BCDP 8.7
Peritoneal eosinophilia 8.7
Suberosis 8.7
Anaphylactoid reaction 8.6
mastocytoma 8.5
Aspirin-sensitive asthma 8.5
Atopic disorders 8.5
Acute anaphylaxis 8.5
Generalized osteopenia 8.5
Infiltrating angiolipoma 8.5
Diffuse cutaneous mastocytosis 8.4
Exercise-induced anaphylaxis 8.3
Vernal keratoconjunctivitis 8.3
allergic conjunctivitis 8.1
vascular hypoxia 8.1
Epidermal necrosis 8.1
allergic edema 8.0
anaphylaxis 8.0
Chronic prurigo 7.9
Hunner 7.9
chronic eosinophilic leukemia 7.8
Secondary disease 7.7
Basophilic Leukemia 7.7
neoplasm location 7.7
Giant papillary conjunctivitis 7.7
Allergic rhinoconjunctivitis 7.6
chronic tracheitis 7.6
Verocay body 7.6
Aquagenic pruritus 7.5
Canine cutaneous histiocytoma 7.5
Acute urticaria 7.4
Perennial allergic rhinitis 7.4
interstitial cystitis 7.3
Tripe palms 7.3
chronic urticaria 7.2
Secondary sclerosing cholangitis 7.2
Cholinergic urticaria 7.2
NARES 7.2
Aquagenic urticaria 7.2
Aleukemic leukemia 7.1
Mazzotti reaction 7.0
dermographia 7.0
ALHE 7.0
AA1 7.0
allergic bronchitis 6.7
Allergic conditions 6.7
comedo carcinoma 6.7
Renal interstitial fibrosis 6.5
Eosinophilic bronchitis 6.5
urticaria 6.4
Pruritic urticarial papules and plaques of pregnancy 6.4
MDS/MPD 6.4
more...
Symptom
clubbed nail 10.1
Vibratory angioedema 9.1
symptom or complaint 8.7
Darier's sign 8.6
Scalp pruritus 8.1
Local reaction 7.9
Purulent discharge 7.7
gastrointestinal colic 7.6
Ear swelling 7.4
Respiratory abnormalities 6.7
Lower abdominal pain 6.5
bladder pain 6.5
sneezing 5.9
Cardiovascular symptoms 5.7
vestibulitis 5.6
Urticarial vasculitis 5.6
nasal congestion 5.4
postnasal drip 5.4
Induced hypothermia 5.4
localized edema 5.3
generalized erythema 5.2
GI irritation 5.1
catarrh 5.1
skin pain 4.8
abiotrophy 4.7
Gastrointestinal symptoms 4.7
rhinorrhea 4.7
Overlying 4.6
Spotting 4.6
onychomadesis 4.6
Flare 4.6
Vulvodynia 4.6
urinary frequency 4.5
flushing 4.4
Nasal symptoms 4.4
HSA 4.3
generalized rash 3.9
pelvic pain 3.7
Welt 3.7
rundown 3.7
frequent urination 3.6
hyperesthesia 3.6
Neurologic symptoms 3.5
adipsia 3.5
erythema 3.5
Chronic pelvic pain 3.4
presyncope 3.4
hepatosplenomegaly 3.3
acute stress 3.3
labored breathing 3.3
pedal edema 3.3
abnormal breathing 3.3
skin damage 3.3
wheezing 3.2
dry skin 3.1
periorbital edema 3.1
chronic cough 3.1
chest tightness 3.1
lightheadedness 3.1
male subfertility 3.0
bone pain 2.9
splenomegaly 2.7
bloating 2.7
microbial colonization 2.6
prostration 2.5
photophobia 2.4
rigors 2.4
diarrhea 2.3
spasm 2.3
hepatomegaly 2.3
Spots 2.2
nasal discharge 2.2
syncope 2.1
stomach pain 2.1
pallor 2.1
tachypnea 2.1
heartburn 2.0
abdominal cramps 2.0
POA 2.0
swollen joints 2.0
more...
Drug
Tiacrilast 10.5
Lodoxamide tromethamine 10.2
Berberine sulfate 10.1
Quazolast 10.1
Patanol 9.9
Alcaftadine 9.7
Bepotastine besilate 9.6
Flutropium bromide 9.5
Emadine 9.5
Fluocortin butyl 9.5
Livostin 9.3
Parotin 9.1
Astelin 9.1
Rimadyl 9.1
Olopatadine hydrochloride 8.7
Platycodon root 8.5
Clamoxyl 8.5
Ketotifen 8.4
Piriprost 8.0
Gefarnate 7.9
Midostaurin 7.9
Emedastine difumarate 7.7
Pemirolast 7.7
3,4-Dichloroisocoumarin 7.6
Diflucortolone valerate 7.6
Muromonab-CD3 7.5
Nedocromil sodium 7.4
Tranilast 7.4
Corydalis tuber 7.4
Ramatroban 7.4
Epinastine 7.3
Histamine 7.2
Desonide 7.2
Zinc gluconate 7.2
Romet 7.1
Azelastine hydrochloride 7.1
Meridia 7.1
Omalizumab 7.0
Sulfamide 7.0
Ganirelix 7.0
Elmiron 7.0
Quinaprilat 7.0
Chlorpheniramine maleate 6.9
Tacalcitol 6.9
Zaditen 6.8
Pentosan polysulfate sodium 6.7
Loteprednol etabonate 6.5
Betamethasone valerate 6.4
Dexamethasone sodium phosphate 6.3
Berberine chloride 6.3
Allergen 6.2
Betamethasone dipropionate 6.2
Pimecrolimus 6.2
Butaprost 6.1
Levocabastine 6.1
Methotrexat 6.0
Petrolatum 5.9
Serevent 5.8
Seldane 5.8
Foradil 5.8
Foradil 5.8
Foradil 5.7
Loratadine 5.7
Plaquenil 5.7
Plaquenil 5.6
Peridinin 5.6
Clemastine 5.5
Zinc sulfate 5.5
Zinc sulfate 5.5
Clobetasol propionate 5.4
Zileuton 5.4
Ipratropium bromide 5.3
Pertussis vaccine 5.3
Hirulog 5.3
Tenidap 5.3
Cerezyme 5.3
Ketorolac tromethamine 5.3
Fluticasone propionate 5.2
Miltefosine 5.2
Protamine sulfate 5.1
more...
Enzyme
carboxypeptidase A 11.0
tryptase 9.8
chymase 9.6
mast cell protease 5 9.1
duodenase 8.4
D-galactose dehydrogenase 8.1
carboxypeptidase B 8.0
CPA2 7.8
CBPP 7.8
tubulin-tyrosine ligase 7.7
D-galactose dehydrogenase 7.7
L-fucose dehydrogenase 7.5
hexosaminidase 7.4
histidine decarboxylase 7.4
GalNAc4S-6ST 7.4
neurolysin 7.1
EC 5.3.99.2 7.0
Aeromonas proteolytica aminopeptidase 6.9
histamine N-methyltransferase 6.8
ceramide kinase 6.6
chondroitin 4-sulfotransferase 6.6
proteinase yscB 6.5
chymotrypsin C 6.4
CPN 6.3
cathepsin G 6.2
LTC4 synthase 6.1
trypsin 6.0
enkephalinase B 5.9
carboxypeptidase S 5.9
carboxypeptidase II 5.8
stratum corneum chymotryptic enzyme 5.8
chondroitin 6-sulfotransferase 5.7
penicillopepsin 5.7
pyroglutamate aminopeptidase 5.7
leucine aminopeptidase 5.7
acyloxyacyl hydrolase 5.7
granzyme K 5.6
thermolysin 5.6
pyroglutamyl peptidase II 5.5
thermitase 5.4
AAE 5.3
trimetaphosphatase 5.3
aminopeptidase B 5.3
DAP II 5.3
cathepsin C 5.3
inositol phosphatase 5.3
sphingosine kinase 5.2
heparinase 5.2
cathepsin V 5.1
oligopeptidase B 5.1
tripeptidase 5.0
N-acetylglucosamine deacetylase 5.0
chymotrypsin 4.9
plasmin 4.9
prostasin 4.8
BAL 4.8
clostripain 4.7
chondroitinase 4.7
KAR 4.7
galactosylhydroxylysyl glucosyltransferase 4.7
phosphatidylinositol 4-kinase 4.7
VIP1 4.6
proteinase-3 4.6
carboxypeptidase Y 4.6
chondroitinase 4.6
chondroitin ABC lyase 4.6
endothiapepsin 4.6
carboxypeptidase G2 4.6
kynureninase 4.5
enterokinase 4.5
elastase 4.4
prolidase 4.4
neuropsin 4.4
carboxypeptidase E 4.4
Hageman factor 4.4
CD13 4.4
procollagen C-proteinase 4.4
acetylesterase 4.3
alpha-lytic protease 4.3
acylphosphatase 4.2
more...
Compound
Geigerin 11.1
1,3-Diethylxanthine 11.1
2-ethyl-2-methylsuccinic acid 10.1
Cremophor-El 10.1
Jacareubin 10.1
Berberine sulfate 10.1
Berberine sulfate 10.1
Nedocromil 9.7
Chelidonic acid 9.6
Cromolyn 9.5
Thapsigargicin 9.5
Pinacyanol 9.5
Azatadine 9.3
Picryl chloride 9.1
Eutonyl 9.1
Olopatadine 8.9
Batatasin I 8.7
1-(2-pyridinyl)piperazine 8.7
1-amino-2-phenylethylphosphonic acid 8.7
2-hydroxy-3-methoxybenzoic acid 8.7
3'-Sialyllactose 8.7
4-(4-hydroxyphenyl)butanoic acid 8.7
Tenulin 8.7
Tenulin 8.7
4-oxopentanoic acid 8.7
2-thiophenecarboxamide 8.5
2-benzylsuccinic acid 8.5
D-Cysteine 8.5
C20H24N2O4 8.5
9-chloroacridine 8.5
Tetracosahexaenoic acid 8.5
chloroacetic anhydride 8.5
11-trans-LTC4 8.5
Disodium cromoglycate 8.4
Chlorpromazine sulphoxide 8.1
C18H12N2 8.1
Palmitoylethanolamide 8.0
Norathyriol 8.0
Columbianetin 7.9
Naphthol AS-D 7.9
cis-Urocanic acid 7.7
C5H6O4 7.7
3-mercaptopropanoic acid 7.6
3-mercaptopropanoic acid 7.6
Narirutin 7.6
Curine 7.6
Toluidine blue 7.6
10,11-dihydro-5H-dibenzo[a,d]cycloheptene 7.5
Nicotine tartrate 7.5
Oxatomide 7.5
5-oxohexanoic acid 7.4
6-phenylhexanoic acid 7.4
D-Phenylalanine 7.3
PGD2 7.3
A 172 7.3
Acetylshikonin 7.2
POPOP 7.2
1,2,4,5-tetramethoxybenzene 7.2
Sodium glycocholate 7.2
Histamine 7.1
Naphthol AS-D 7.1
Emedastine 7.1
L-Phenylalanine, 7.1
Rhaponticin 7.0
[6]-Shogaol 7.0
Bisdemethoxycurcumin 6.9
Chymostatin 6.9
Eupafolin 6.8
Amarogentin 6.8
Zopolrestat 6.8
Mepyramine 6.8
L-365260 6.7
Cytochalasin A 6.7
Hexahydrophthalic anhydride 6.7
Levulinic acid 6.7
Z-Gly 6.7
2-Pyridylethylamine 6.7
D-Proline 6.7
LTC4 6.6
methylhistamine 6.6
more...