Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P15088 (mast cell)
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Human Gene/Protein
mast cell 11.1
mMCP-7-like I 11.1
CAPPA1 11.1
MC-CPA 11.1
tryptase I 11.1
PI4KAP1 11.1
G-protein-coupled receptor 34 11.1
Tryptase I 11.1
carboxypeptidase A3 10.6
mast cell protease I 10.5
MAS-related G protein-coupled receptor 10.4
MRGPRX2 10.3
beta-tryptase 10.2
mast cell protease II 10.1
Endothelial collagen 10.1
mitogen- and stress-activated protein kinase 2 10.1
Mast cell tryptase 10.1
peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor 10.1
sialyltransferase 4C 10.1
LAD2 10.0
FcERI 9.8
Carboxypeptidase A 9.8
CPA3 9.8
skin tryptase 9.8
mast cell tryptase 9.6
chymase 9.6
TPSAB1 9.6
STXBP2 protein 9.5
TPSB2 9.5
EN-7 9.5
CERK protein 9.5
C12orf4 9.5
fibronectin leucine rich transmembrane protein 3 9.5
Transient receptor potential cation channel, subfamily V, member 4 9.5
SCAMP-4 9.5
protease E) 9.5
CPA5 9.5
TSBP 9.5
FceRI 9.4
Chymase 9.3
more...
Disease
Idiopathic angioedema 11.1
Neutrophilic urticaria 11.1
Allergic gastroenteritis and colitis 11.1
SM-AHNMD 10.6
Malignant mastocytosis 10.5
Seasonal allergic conjunctivitis 10.3
Systemic mastocytosis 10.1
mast cell leukemia 10.1
Chronic allergic conjunctivitis 10.1
Perennial allergic conjunctivitis 10.1
Complete atelectasis 10.1
Mastocytosis 10.0
Atopic keratoconjunctivitis 9.9
mastocytosis 9.8
urticaria pigmentosa 9.7
Cutaneous mastocytosis 9.6
Telangiectasia macularis eruptiva perstans 9.6
LAD2 9.5
Heteroplasia 9.5
Idiopathic anaphylaxis 9.5
Chronic autoimmune urticaria 9.5
Atopic allergy 9.5
Familial mastocytosis 9.5
MPD3 9.1
Solitary mastocytoma 9.1
Acral lick dermatitis 9.1
Chronic idiopathic urticaria 8.9
Mastocytoma 8.9
BCDP 8.7
Peritoneal eosinophilia 8.7
Suberosis 8.7
Anaphylactoid reaction 8.6
mastocytoma 8.5
Acute anaphylaxis 8.5
Aspirin-sensitive asthma 8.5
Atopic disorders 8.5
Generalized osteopenia 8.5
Infiltrating angiolipoma 8.5
Diffuse cutaneous mastocytosis 8.4
Exercise-induced anaphylaxis 8.3
more...
Symptom
clubbed nail 10.1
Vibratory angioedema 9.1
symptom or complaint 8.7
Darier's sign 8.6
Scalp pruritus 8.1
Local reaction 7.9
Purulent discharge 7.7
gastrointestinal colic 7.6
Ear swelling 7.4
Respiratory abnormalities 6.7
Lower abdominal pain 6.5
bladder pain 6.5
sneezing 5.9
Cardiovascular symptoms 5.7
vestibulitis 5.6
Urticarial vasculitis 5.6
nasal congestion 5.4
postnasal drip 5.4
Induced hypothermia 5.4
localized edema 5.3
generalized erythema 5.2
GI irritation 5.1
catarrh 5.1
skin pain 4.8
abiotrophy 4.7
Gastrointestinal symptoms 4.7
rhinorrhea 4.7
Overlying 4.6
onychomadesis 4.6
Spotting 4.6
Flare 4.6
Vulvodynia 4.6
urinary frequency 4.5
flushing 4.4
Nasal symptoms 4.4
HSA 4.3
generalized rash 3.9
pelvic pain 3.7
Welt 3.7
rundown 3.7
more...
Drug
Tiacrilast 10.5
Lodoxamide tromethamine 10.2
Quazolast 10.1
Berberine sulfate 10.1
Patanol 9.9
Alcaftadine 9.7
Bepotastine besilate 9.6
Emadine 9.5
Flutropium bromide 9.5
Fluocortin butyl 9.5
Livostin 9.3
Parotin 9.1
Rimadyl 9.1
Astelin 9.1
Olopatadine hydrochloride 8.7
Platycodon root 8.5
Clamoxyl 8.5
Ketotifen 8.4
Piriprost 8.0
Midostaurin 7.9
Gefarnate 7.9
Emedastine difumarate 7.7
Pemirolast 7.7
3,4-Dichloroisocoumarin 7.6
Diflucortolone valerate 7.6
Muromonab-CD3 7.5
Nedocromil sodium 7.4
Tranilast 7.4
Corydalis tuber 7.4
Ramatroban 7.4
Epinastine 7.3
Histamine 7.2
Zinc gluconate 7.2
Desonide 7.2
Azelastine hydrochloride 7.1
Meridia 7.1
Romet 7.1
Omalizumab 7.0
Quinaprilat 7.0
Sulfamide 7.0
more...
Enzyme
carboxypeptidase A 11.0
tryptase 9.8
chymase 9.6
mast cell protease 5 9.1
duodenase 8.4
D-galactose dehydrogenase 8.1
carboxypeptidase B 8.0
CPA2 7.8
CBPP 7.8
tubulin-tyrosine ligase 7.7
D-galactose dehydrogenase 7.7
L-fucose dehydrogenase 7.5
hexosaminidase 7.4
histidine decarboxylase 7.4
GalNAc4S-6ST 7.4
neurolysin 7.1
EC 5.3.99.2 7.0
Aeromonas proteolytica aminopeptidase 6.9
histamine N-methyltransferase 6.8
ceramide kinase 6.6
chondroitin 4-sulfotransferase 6.6
proteinase yscB 6.5
chymotrypsin C 6.4
CPN 6.3
cathepsin G 6.2
LTC4 synthase 6.1
trypsin 6.0
enkephalinase B 5.9
carboxypeptidase S 5.9
carboxypeptidase II 5.8
stratum corneum chymotryptic enzyme 5.8
chondroitin 6-sulfotransferase 5.7
penicillopepsin 5.7
pyroglutamate aminopeptidase 5.7
leucine aminopeptidase 5.7
acyloxyacyl hydrolase 5.7
granzyme K 5.6
thermolysin 5.6
pyroglutamyl peptidase II 5.5
thermitase 5.4
more...
Compound
Geigerin 11.1
1,3-Diethylxanthine 11.1
Berberine sulfate 10.1
2-ethyl-2-methylsuccinic acid 10.1
Cremophor-El 10.1
Jacareubin 10.1
Berberine sulfate 10.1
Nedocromil 9.7
Chelidonic acid 9.6
Cromolyn 9.5
Pinacyanol 9.5
Thapsigargicin 9.5
Azatadine 9.3
Picryl chloride 9.1
Eutonyl 9.1
Olopatadine 8.9
2-hydroxy-3-methoxybenzoic acid 8.7
1-amino-2-phenylethylphosphonic acid 8.7
4-(4-hydroxyphenyl)butanoic acid 8.7
Tenulin 8.7
Batatasin I 8.7
1-(2-pyridinyl)piperazine 8.7
3'-Sialyllactose 8.7
Tenulin 8.7
4-oxopentanoic acid 8.7
2-benzylsuccinic acid 8.5
9-chloroacridine 8.5
2-thiophenecarboxamide 8.5
Tetracosahexaenoic acid 8.5
11-trans-LTC4 8.5
C20H24N2O4 8.5
D-Cysteine 8.5
chloroacetic anhydride 8.5
Disodium cromoglycate 8.4
C18H12N2 8.1
Chlorpromazine sulphoxide 8.1
Palmitoylethanolamide 8.0
Norathyriol 8.0
Columbianetin 7.9
Naphthol AS-D 7.9
more...