Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P15088 (mast cell)
 14,925 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
mast cell 14925
IgE 2601
cytokine 1076
Sep 978
Mol 615
IL-4 560
c-kit 538
chymase 509
stem cell factor 472
IL-6 453
substance P 387
tumor necrosis factor 362
IL-3 350
TNF 341
collagen 321
KIT 295
TNF-alpha 262
IL-13 257
gut 250
IL-5 243
tyrosine kinase 223
IL-8 219
beta II 208
lymphoid 192
IL-10 180
chemokine 172
albumin 168
p38 168
mast cell tryptase 166
cyclooxygenase 158
CD4 141
bradykinin 136
chymotrypsin 135
lipopolysaccharide 133
interleukin-4 131
CD117 128
myeloperoxidase 125
PGD2 124
serum albumin 121
5-hydroxytryptamine 120
granulocyte 116
ATP 116
erythroid 115
serine protease 114
IL-33 113
ERK 112
proteoglycan 111
CD34 109
IFN-gamma 108
polypeptide 108
esterase 108
interferon 105
MAPK 105
histidine decarboxylase 104
IFN 103
fibronectin 102
IL-1 99
interleukin-6 96
LAD2 94
LPS 92
nerve growth factor 92
mast cell growth factor 91
IL-2 90
calcitonin 89
SDS 89
5-lipoxygenase 88
phosphatase 87
receptor tyrosine kinase 84
peroxidase 83
insulin 82
JNK 81
CD25 80
membrane-bound 80
IL-9 80
AMP 78
vascular endothelial growth factor 77
GM-CSF 77
thymus 76
CD8 75
PI3K 73
lipoxygenase 73
thrombin 72
phospholipase 72
angiotensin II 71
glycoprotein 70
mitogen-activated protein 69
RANTES 69
lectin 69
nitric oxide synthase 68
carboxypeptidase B 68
thymic stromal lymphopoietin 66
Chymase 65
ICAM-1 63
superoxide dismutase 63
endoplasmic reticulum 62
extracellular signal-regulated kinase 62
SCF 62
Cytokine 62
Ang II 62
adhesion molecule 62
IgA 62
PGD 62
cyclooxygenase-2 61
peptidase 61
collagenase 61
eotaxin 61
interferon-gamma 60
phospholipase A2 60
matrix metalloproteinase 60
trypsin inhibitor 60
cathepsin G 58
adenosine receptor 58
proto-oncogene 58
tumor necrosis factor alpha 58
beta-endorphin 57
IL-17 57
kit 56
MCP-1 56
TLR4 56
CCL2 55
C48 55
caspase-3 55
histamine H1 receptor 54
fused 53
ERK1 53
COX-2 53
TGF-beta 51
chymotrypsin-like 51
neurotensin 50
CSF 50
granulocyte-macrophage colony-stimulating factor 50
PAF 50
TLR2 48
PKC 47
CD45 47
somatostatin 46
p53 46
p38 mitogen-activated protein kinase 45
amylase 44
granulocyte-macrophage 44
inducible nitric oxide synthase 44
phosphatidylinositol 3-kinase 44
CD2 44
CD11b 44
CD68 43
hemoglobin 43
PAR-2 43
NMR 43
renin 43
eosinophil cationic protein 42
Fc gamma 42
megakaryocyte 42
Bcl-2 42
MMP-9 42
lactate dehydrogenase 42
phosphodiesterase 41
Fc receptor 41
leucine aminopeptidase 41
lipase 41
FPL 41
more...
Disease
asthma 1208
anaphylaxis 943
mastocytosis 917
tumor 817
cancer 513
leukemia 408
atopic dermatitis 330
mastocytoma 307
urticaria 263
pruritus 257
allergic rhinitis 245
eosinophilia 219
Mastocytosis 147
food allergy 143
dermatitis 139
urticaria pigmentosa 137
cold 131
Systemic mastocytosis 127
pertussis 122
ischemia 113
lymphoma 108
arthritis 107
skin disease 105
rheumatoid arthritis 103
allergic conjunctivitis 99
LAD2 94
interstitial cystitis 92
rhinitis 92
mast cell leukemia 90
SDS 89
sarcoma 88
diabetes 86
atherosclerosis 86
psoriasis 85
carcinoma 84
worms 84
inflammatory bowel disease 83
chronic urticaria 83
acute myeloid leukemia 81
irritable bowel syndrome 79
bronchospasm 76
tumor growth 76
multiple sclerosis 75
metastases 74
melanoma 72
plaque 71
conjunctiva 66
colitis 65
multiple myeloma 65
Evans 63
SEM 61
conjunctivitis 60
infectious diseases 60
tumorigenesis 60
bacterial infection 55
chronic myeloid leukemia 54
myeloproliferative disorders 54
adenocarcinoma 53
hypertension 53
peritonitis 53
myocardial infarction 52
uterus 52
carcinogenesis 51
keratoconjunctivitis 50
PAF 50
squamous cell carcinoma 50
anemia 50
vasculitis 49
autoimmune disease 49
ulcerative colitis 48
Brown 48
NAME 47
depression 47
tumor progression 46
virus infection 44
myelodysplastic syndrome 44
migraine 44
Infection 44
breast cancer 42
osteoporosis 42
hay fever 41
pemphigoid 41
sepsis 39
encephalomyelitis 38
sepsis 38
chronic obstructive pulmonary disease 37
rare disease 36
heart failure 36
scleroderma 35
Crohn's disease 35
thrombocytopenia 35
cystitis 34
sinusitis 34
stromal tumors 34
rash 34
Schistosoma mansoni 32
obesity 32
cholera 32
systemic lupus erythematosus 32
Contact Dermatitis 31
lung disease 31
gastritis 30
Dermal 30
pulmonary fibrosis 29
Hodgkin's disease 29
myocardial ischemia 27
DBA 27
mole 27
systemic disease 27
skin cancer 26
cardiovascular disease 25
cystic fibrosis 25
stroke 25
meninges 25
tumor angiogenesis 25
pneumonia 25
neurofibroma 24
Adhesion 24
fibrosarcoma 24
eczema 23
PCA 23
neurofibromatosis type 1 23
psychological stress 23
dysplasia 23
cornea 23
APC 23
Blocking 23
MIP 23
respiratory disease 23
polyposis 22
chronic disease 22
chronic pain 22
dengue 22
pulmonary hypertension 21
sarcoidosis 21
neutropenia 21
SCID 21
SRS 21
gastric ulcer 21
polycythemia vera 21
lymphadenopathy 20
lupus 20
Alzheimer's disease 20
drug hypersensitivity 20
angiosarcoma 20
celiac disease 19
HIV 19
osteosarcoma 19
acute myocardial infarction 19
pulmonary edema 19
dyspepsia 19
GSH 19
immunopathology 19
mole 19
osteoarthritis 19
Bordetella 19
enteropathy 18
influenza 18
Cutaneous mastocytosis 18
chronic myelomonocytic leukemia 18
more...
Symptom
pain 239
diarrhea 137
Welt 99
erythema 69
anesthesia 66
flushing 64
headache 53
sneezing 52
abdominal pain 50
collapse 44
vomiting 41
cough 39
splenomegaly 31
hypothermia 30
dyspnea 28
rhinorrhea 27
HSA 27
nausea 27
pelvic pain 25
nasal congestion 23
acute stress 22
hepatosplenomegaly 21
fatigue 20
wheezing 20
syncope 19
analgesia 18
spasm 17
bladder pain 16
chest pain 16
discomfort 16
discomfort 16
angina 16
respiratory distress 15
seizures 13
hepatomegaly 13
urinary frequency 12
bone pain 11
Darier's sign 9
starvation 8
chronic cough 8
sleepiness 8
constipation 8
skin damage 7
Gastrointestinal symptoms 7
thinning 7
tachypnea 5
postnasal drip 5
Ear swelling 5
bloating 5
pallor 5
lethargy 5
functional recovery 5
arthralgia 5
weakness 5
cyanosis 5
hyperoxia 5
acute pain 4
dry skin 4
shortness of breath 4
stridor 4
heartburn 4
photophobia 4
anorexia 4
Ill 4
tremor 4
nausea and vomiting 4
hoarseness 3
rundown 3
hyperesthesia 3
microbial colonization 3
skin irritation 3
exhaustion 3
back pain 3
agitation 3
chest tightness 3
presyncope 3
vestibulitis 3
nasal discharge 3
myalgia 3
cancer pain 3
paresthesia 3
dizziness 3
dysuria 3
acidity 3
catarrh 3
vertigo 2
masculinization 2
Flare 2
Sedation 2
epigastric pain 2
incoordination 2
rigors 2
paresis 2
Local reaction 2
lightheadedness 2
polyuria 2
dental pain 2
localized edema 2
abdominal discomfort 2
low back pain 2
acute abdominal pain 2
memory loss 2
sore throat 2
dry eye 2
generalized erythema 2
Vibratory angioedema 1
generalized rash 1
prostration 1
labored breathing 1
frequent urination 1
blepharospasm 1
numbness 1
acute abdomen 1
asynergy 1
abdominal cramps 1
decreased appetite 1
Scalp pruritus 1
Neurologic symptoms 1
leg pain 1
colic 1
ENT 1
catatonia 1
menopausal symptoms 1
Respiratory abnormalities 1
polydipsia 1
swollen joints 1
POA 1
pedal edema 1
clubbed nail 1
Vulvodynia 1
onychomadesis 1
stomach pain 1
symptom or complaint 1
Urticarial vasculitis 1
gastrointestinal colic 1
excessive sweating 1
Nasal symptoms 1
Purulent discharge 1
clubbing 1
abiotrophy 1
anosmia 1
Chronic pelvic pain 1
DNA marker 1
abnormal breathing 1
skin pain 1
GI irritation 1
Spotting 1
Overlying 1
cachexia 1
bitter taste 1
enuresis 1
adipsia 1
facial pain 1
male subfertility 1
insomnia 1
Cardiovascular symptoms 1
Induced hypothermia 1
Spots 1
Neuropathic pain 1
periorbital edema 1
more...
Drug
Dermatol 520
Histamine 374
Asthma 185
CSF 115
IFN-gamma 106
lysine 94
IL-2 93
Allergen 54
Ketotifen 45
CTX 43
Asn 43
Indomethacin 31
Imatinib 30
ABC 27
MAP 26
ROS 26
Cardiovasc 25
Omalizumab 25
Gel 23
L-tyrosine 17
Tranilast 16
Diphenhydramine 15
Nedocromil sodium 15
Gleevec 15
Atropine 15
Theophylline 14
Ethanol 13
vitamin E 13
Cimetidine 12
Bifidobacterium 12
Cimetidine 12
p75 11
G-CSF 11
ETA 11
Fluorescein 10
ICI 10
Leaf 9
lactose 9
Salbutamol 9
Pronase 9
Tacrolimus 8
Midostaurin 7
Prednisolone 7
IL-11 7
DNase I 7
CCL 7
Olopatadine hydrochloride 7
Captopril 6
Paraffin 6
Loratadine 6
Ouabain 6
citric acid 6
Fluorescein 6
niacin 6
Angiotensin II 6
EE2 5
Lodoxamide tromethamine 5
CaCl2 5
Patanol 5
TAT 5
Propofol 5
Aprotinin 5
Budesonide 5
ascorbate 5
Phosphatidylserine 5
MEA 5
CaCl2 5
CaCl2 5
Alanine 4
Berberine sulfate 4
Dasatinib 4
PTH 4
Reserpine 4
Forskolin 4
Norplant 4
DFP 4
Gastro 4
MDS 4
Miltefosine 4
balanced salt solution 4
Mutagen 4
Methylene blue 4
Ginseng 4
caffeine 4
Ranitidine 4
NADH 4
Ipratropium bromide 4
Activin 4
Bepotastine besilate 4
Albumin 4
Pimecrolimus 4
Codeine 4
ZnO 4
-deoxyadenosine 4
Nephron 4
Triclosan 4
Bosentan 3
nitroglycerin 3
Omeprazole 3
IFN-beta 3
Aminoguanidine 3
Bosentan 3
Spectrum 3
Silica gel 3
Atenolol 3
ALA 3
IL-1ra 3
CTM 3
Codeine 3
PPA 3
Estrogens 3
Ringer's solution 3
Zaditen 3
Cremophor EL 3
ETS 3
TEL 3
Zileuton 3
CTM 3
NAG 3
Nitric Oxide 3
Adriamycin 3
Misoprostol 3
GEO 3
Clobetasol propionate 3
Gelatin 3
EPA 3
Biopolymers 3
ampicillin 3
Ammonium chloride 2
Metrizamide 2
Sulphasalazine 2
Fraction 2
Protamine sulfate 2
Butaprost 2
MRC 2
Adenosine deaminase 2
Fentanyl 2
Fluticasone propionate 2
Piriprost 2
Rolipram 2
Epinastine 2
Hypaque 2
Zinc sulfate 2
Clonidine 2
Giardiasis 2
Rutin 2
Tubocurarine 2
Imiquimod 2
Dalteparin 2
uPA 2
Ketorolac tromethamine 2
Gelfoam 2
Livostin 2
Levocabastine 2
TiO2 2
Photofrin 2
Rocuronium 2
Ethane 2
Trifluoperazine 2
PFA 2
more...
Enzyme
trypsin 1226
tryptase 1140
carboxypeptidase A 957
chymase 498
ERK 474
mitogen-activated protein kinase 361
hexosaminidase 289
peroxidase 227
protein kinase C 181
chymotrypsin 155
plasmin 122
histidine decarboxylase 113
focal adhesion kinase 106
protein kinase 101
phospholipase A2 100
elastase 93
phospholipase C 91
collagenase 81
carboxypeptidase B 74
lipoxygenase 73
superoxide dismutase 71
thrombin 71
cathepsin G 61
caspase-1 51
reverse transcriptase 49
lactate dehydrogenase 48
caspase-3 46
hyaluronidase 46
phosphatidylinositol 3-kinase 44
thermolysin 44
renin 43
pepsin 42
CD10 41
luciferase 41
adenylate cyclase 41
lipase 41
phosphodiesterase 41
ACE 40
ATPase 40
leucine aminopeptidase 39
calcineurin 38
NO synthase 36
catalase 35
CD13 35
MEK 33
lysozyme 32
kallikrein 31
phosphoinositide 3-kinase 31
alkaline phosphatase 30
beta-glucuronidase 30
papain 28
hyaluronidase 27
neutrophil elastase 27
chondroitinase 26
neuraminidase 26
xanthine oxidase 26
proteasome 26
BAL 25
RNase 24
MIP 23
chondroitinase 23
heparinase 22
RNase 22
MAP 22
APC 21
NADPH oxidase 20
diamine oxidase 20
granzyme B 20
RNA polymerase 19
subtilisin 19
cathepsin D 18
phospholipase D 17
CPN 16
acetylcholinesterase 16
NADPH oxidase 16
matrix metalloproteinase 9 15
alpha-amylase 15
sulfatase 15
carboxypeptidase Y 15
IKK 15
guanylate cyclase 14
MMP-3 14
acid phosphatase 14
creatine kinase 14
NOS 13
ACS 13
sphingosine kinase 13
carboxylesterase 12
carbonic anhydrase 11
P-glycoprotein 11
AMPK 11
urokinase-type plasminogen activator 11
alanine aminotransferase 10
histamine N-methyltransferase 10
transcriptase 10
glutathione peroxidase 10
prostaglandin synthetase 10
ribonuclease 9
thromboplastin 9
ribonuclease 9
tyrosinase 9
cathepsin B 9
glutathione S-transferase 9
phosphatidylinositol 4-kinase 8
proteinase K 8
PARP 8
tryptophan hydroxylase 8
aldolase 8
DNase 7
ornithine decarboxylase 7
aspartate aminotransferase 7
cathepsin C 7
enterokinase 7
arylsulfatase 7
tissue plasminogen activator 7
neurolysin 6
AMPK 6
deaminase 6
MEKK1 6
MMP 6
inositol phosphatase 6
enolase 6
CPA2 6
caspase-9 6
aldehyde dehydrogenase 6
tissue kallikrein 6
PDE 6
15-lipoxygenase 6
arginase 6
AMP-activated protein kinase 6
alcohol dehydrogenase 6
heme oxygenase 5
PNGase F 5
beta-galactosidase 5
gamma-glutamyl transpeptidase 5
farnesyltransferase 5
caspase-8 5
TAT 5
monoamine oxidase 5
prolidase 5
Hageman factor 5
adenosine deaminase 5
MDP 5
adenosine deaminase 5
CBPP 5
ceramide kinase 5
glutathione reductase 5
glyceraldehyde-3-phosphate dehydrogenase 4
pyroglutamate aminopeptidase 4
GSK 4
complex I 4
SPT 4
transglutaminase 4
matrix metalloproteinase 2 4
DTA 4
PDK1 4
Thy1 4
dihydrofolate reductase 4
SPT 4
thymidylate synthase 4
more...
Compound
calcium 1211
Dec 1002
Clin 937
tyrosine 486
sodium 459
Histamine 374
TNF 341
water 336
DNA 303
serine 303
acetate 290
arginine 276
Phe 241
zinc 239
oxygen 235
sulfate 218
nitric oxide 185
lysine 173
phosphate 155
PGD2 138
His 138
leucine 137
alanine 136
LTC4 133
ethanol 124
ATP 117
cAMP 109
Gly 105
DNP 103
5-HT 101
Asp 97
NH2 93
SDS 93
threonine 87
AMP 84
glucose 82
PGE2 81
salt 79
hydrogen 79
methionine 72
cysteine 71
potassium 68
PMA 67
Disodium cromoglycate 66
PMA 66
Substance P 63
bromide 61
Ile 61
Heparin 55
Adenosine 55
Toluidine blue 53
cobalt 52
formaldehyde 51
methylhistamine 51
acetic acid 50
EDTA 49
EDTA 49
tryptophan 49
galactose 48
nitrogen 46
Cardiol 46
iron 43
tryptophan 43
CTX 43
PGE 42
tryptophan 42
tryptophan 42
aldehyde 41
ASA 40
copper 39
CPA 38
CPA 38
GTP 38
CPA 38
urea 38
CPA 38
formaldehyde 37
HCl 36
methanol 36
aldehyde 35
silver 35
DBA 34
ADP 33
glutamate 32
Indomethacin 31
ADP 30
Dexamethasone 30
ADP 30
ammonium 30
Cromolyn 29
Tyrosine 28
Ang II 27
MTT 27
DBA 27
retinoic acid 27
DBA 27
PEG 27
BAL 26
DEAE 26
LTE4 26
glutamic acid 26
Trypsin 26
hydroxide 25
aspartic acid 25
1-chloro-2,4-dinitrobenzene 25
COS 24
aspartic acid 24
FK506 24
aspartic acid 24
cGMP 24
aspartic acid 24
proline 24
H2O2 23
prostacyclin 23
MEK 23
Serine 23
iodine 23
MAP 22
valine 22
Mg2+ 21
GSH 21
GSH 21
acetone 20
adenylate 20
Morphine 20
Capsaicin 19
noradrenaline 19
chloroform 19
creatinine 19
TPA 19
ACTH 19
PLA 19
TPA 19
hyaluronic acid 18
Pac 18
Bradykinin 18
CO2 18
MMC 18
isoleucine 17
alloxan 17
GlcNAc 17
manganese 17
Triton X-100 17
prostaglandin E1 17
asparagine 17
vitamin D 17
Theophylline 17
Mepyramine 16
glycerol 16
nickel 16
Prostaglandin 16
toluene 16
Hematoxylin 16
nicotinamide 16
Prostaglandin 16
isoleucine 16
Arachidonic acid 15
Atropine 15
nitrate 15
TEM 15
more...