Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P15088 (
mast cell
)
14,925
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Much is known regarding participations of mast cells with innate and acquired immunity by secreting various cytokines and chemical mediators. However, details of
mast cell
biology still remain unclear. In this study, we successfully established a novel growth factor-independent
mast cell
line (
MPT-1
) derived from canine
mast cell
tumor.
MPT-1
cells manifested factor-independent proliferation as floating cells containing a large amount of histamine, as well as chymase-like dog mast cell protease 3, in cytosolic granules. Particularly,
MPT-1
cells expressed high-affinity IgE receptors (FcepsilonRI) and wild-type c-kit receptors. Degranulation of
MPT-1
cells was induced not only by stimulation with calcium ionophore but also by cross-linkage of the surface IgE. Given that
MPT-1
is the first
mast cell
line with FcepsilonRI which has no c-kit mutations,
MPT-1
cells may provide great contribution for investigation of IgE-mediated activation mechanisms of mast cells, leading to development of effective treatment for allergic disorders.
...
PMID:Establishment of a novel high-affinity IgE receptor-positive canine mast cell line with wild-type c-kit receptors. 1808 53
