Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P15088 (mast cell)
 14,925 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A study was undertaken to investigate the effect of some oral contraceptive (OC) steroids on female albino rats ingesting lynestrol and mestranol or mestranol only. Mestranol and the lynestrol-mestranol combination insignificantly altered the total uterine mast cell count. Lynestrol treatment resulted in a highly significant reduction of the total count (p less than .01). Although only significant in rats receiving lynestrenol, the endometrial mast cell count was decreased during OC treatment. Histological changes in the uterus reflecting the predominance of estrogenic activity occurred from all OCs used. Mestranol most potently induced this effect followed by lynestrenol and the combined OCs, respectively. Evidence suggests that endogenous histamine may be involved in tissue growth and repair. Results from this study suggested that histamine implicated in the physiological functions of the uterus is probably of a non-mast-cell origin.
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PMID:The effect of lyndiol and its components on the rat uterine histology and most cell content. 1233 68