Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P15088 (mast cell)
 14,925 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A number of different mouse strains and immunization protocols were used to attempt to make monoclonal antibodies against rat IgE for use in studies of the structure, biological activities and regulation of this class of antibody. Successful production of large numbers of monoclonal antibodies was achieved when mast cell deficient (w/wv and sl/sld) but not conventional (BALB/c, CAF1 or SJL) mice were used. These results suggest that the poor response of conventional strains of mice to rat IgE may be due to the presence of mast cells bearing high affinity receptors for IgE in these mice.
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PMID:Production of large numbers of hybridomas producing monoclonal antibodies against rat IgE using mast cell-deficient w/wv and sl/sld strains of mice. 252 73

A significant incidence of cutaneous mastocytomas was observed in female mice of CAF1/J and ARS-HA (ICR) strains upon long-term application of cigarette smoke condensate suspensions ("tar"). The mastocytomas were not detected in control groups treated with acetone, benzo(a)pyrene (BaP), tetradecanoyl phorbol acetate (TPA), nor in mice treated once with an initiator dose of 75 mg 7, 12-dimethylbenz(a)anthracene (DMBA). The skin mastocytomas were constantly accompanied by diffuse dermal mast cell infiltration (DDMI), which was also seen in the tumor-free skin of the "tar"-treated mice. These results indicate that mastocytomas were induced by agents present in the cigarette smoke condensate. DDMI might be a precursor of mastocytomas.
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PMID:A study of tobacco carcinogenesis XX: mastocytoma induction in mice by cigarette smoke particulates ("cigarette tar"). 678 87