Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P15088 (
mast cell
)
14,925
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Zinc ion in solution yields a 560-fold enhancement in the kinetic inhibition of
carboxypeptidase A
by the simple heterocycle imidazole, behavior attributed to formation of a ternary complex of the three species. However, the effect is partially negated by formation of less-inhibitory Zn2+(
C3H4N2
)2-4 coordination complexes, providing for the enzyme an anomalous profile of catalytic rate versus imidazole concentration.
...
PMID:Synergistic inhibition of carboxypeptidase A by zinc ion and imidazole. 1009 40
