Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P15088 (mast cell)
 14,925 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Human mast cells and basophil granulocytes can be easily recognized in normal tissues by light microscopy. In one mast cell and one basophilic leukemic case considered in this study, mast cells and basophils were morphologically quite similar and could not therefore be clearly defined merely by their morphological features. Both types of cells showed round nuclei and deep purple granules. The diagnosis of mast cell leukemia or basophilic leukemia was made on the basis of different cytochemical patterns. In the case of mast cell leukemia, peroxidase and PAS stains were negative, while chloroesterase was strongly positive; in the case of basophilic leukemia, peroxidase and PAS stains were positive, while chloroesterase reaction showed a peculiar pattern. Toluidine blue metachromasia and astra blue positivity were present in the cells of both cases.
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PMID:Mast cell leukemia and acute basophilic leukemia. Cytochemical studies. 74 30

The demonstration and frequency of mixed granulated, hybrid leukocytes in chronic myeloid leukemia are reported. The cells exhibit basophilic granules, and, in addition, variable quantities of eosinophilic and/or azurophilic (chloroesterase-positive) granules. The existence of further subtypes of granules in these cells, such as neutrophilic or tissue mast cell granules, cannot be excluded thus far. All cases under investigation showed such cells, though in varying frequency. Quality and quantities of the granule population in these cells differed considerably. This is interpreted as an expression of tumor cell heterogeneity, which represents a general criterion of malignant neoplasias. The cells under discussion may be termed hybrid or chimeric, since they are characterized by the co-expression in the same cells of markers (granules) normally subject to lineage specificity. Therefore, the cells represent the phenomenon of "lineage infidelity". Thus far, "lineage infidelity" has been found only with blast cell leukemias, but applies also to chronic myeloid leukemias, as our results show. The occurrence of "lineage infidelity" in segmented end stage cells expresses grave irreversible genetic disturbances of the differentiation program in the progenitors of the hybrid leukocytes.
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PMID:[Recognition and significance of hybrid granulocytes in chronic myeloid leukemia]. 386 44